Patents by Inventor Juan Alvarez
Juan Alvarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210177983Abstract: The present invention provides novel, single chain Fc fusion proteins having improved properties. The invention provides single chain fusions of soluble proteins fused to the Fc region of an immunoglobulin via a novel linker comprising a constant region of an immunoglobulin light chain linked to a CH1 constant region of an immunoglobulin heavy chain. This novel linker confers favorable properties on the Fc fusion proteins of the invention such as improved bioactivity and increased half-life as compared to non-Fc fusion counterparts or as compared to prior art Fc fusion proteins. The novel Fc fusion protein scaffold as described herein may be designed to include soluble proteins of interest capable of binding or interacting with any target of interest. Preferably, the Fc fusion protein of the invention is a dimer. The dimer preferably forms via a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins of the invention.Type: ApplicationFiled: November 30, 2020Publication date: June 17, 2021Inventors: Juan Alvarez, Demetri T. Moustakas, Heather R. Brodkin, Leslie A. McSweeney
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Patent number: 10954250Abstract: The present invention relates to compounds of Formula I:Type: GrantFiled: February 3, 2015Date of Patent: March 23, 2021Assignee: Alkermes Pharma Ireland LimitedInventors: Laura Cook Blumberg, John A. Lowe, III, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan
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Patent number: 10881741Abstract: The present invention provides novel, single chain Fc fusion proteins having improved properties. The invention provides single chain fusions of soluble proteins fused to the Fc region of an immunoglobulin via a novel linker comprising a constant region of an immunoglobulin light chain linked to a CH1 constant region of an immunoglobulin heavy chain. This novel linker confers favorable properties on the Fc fusion proteins of the invention such as improved bioactivity and increased half-life as compared to non-Fc fusion counterparts or as compared to prior art Fc fusion proteins. The novel Fc fusion protein scaffold as described herein may be designed to include soluble proteins of interest capable of binding or interacting with any target of interest. Preferably, the Fc fusion protein of the invention is a dimer. The dimer preferably forms via a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins of the invention.Type: GrantFiled: April 10, 2018Date of Patent: January 5, 2021Assignee: Alkermes, Inc.Inventors: Juan Alvarez, Demetri T. Moustakas, Heather R. Brodkin, Leslie A. McSweeney
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Patent number: 10407481Abstract: The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.Type: GrantFiled: July 25, 2016Date of Patent: September 10, 2019Assignee: Alkermes Pharma Ireland LimitedInventor: Juan Alvarez
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Patent number: 10183979Abstract: The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.Type: GrantFiled: February 16, 2016Date of Patent: January 22, 2019Assignee: Alkermes, Inc.Inventors: Juan Alvarez, Leslie A. McSweeney
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Publication number: 20180289825Abstract: The present invention provides novel, single chain Fc fusion proteins having improved properties. The invention provides single chain fusions of soluble proteins fused to the Fc region of an immunoglobulin via a novel linker comprising a constant region of an immunoglobulin light chain linked to a CH1 constant region of an immunoglobulin heavy chain. This novel linker confers favorable properties on the Fc fusion proteins of the invention such as improved bioactivity and increased half-life as compared to non-Fc fusion counterparts or as compared to prior art Fc fusion proteins. The novel Fc fusion protein scaffold as described herein may be designed to include soluble proteins of interest capable of binding or interacting with any target of interest. Preferably, the Fc fusion protein of the invention is a dimer. The dimer preferably forms via a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins of the invention.Type: ApplicationFiled: April 10, 2018Publication date: October 11, 2018Inventors: Juan Alvarez, Demetri T. Moustakas, Heather R. Brodkin, Leslie A. McSweeney
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Patent number: 10023623Abstract: The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g. pharmacokinetic and/or physicochemical properties) compared to the same active protein not linked to mucin-domain polypeptide, as well as methods for making and using the fusion proteins of the invention.Type: GrantFiled: September 1, 2015Date of Patent: July 17, 2018Assignee: Alkermes, Inc.Inventors: Juan Alvarez, Jean Chamoun, Heather C. Losey
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Publication number: 20170044228Abstract: The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.Type: ApplicationFiled: July 25, 2016Publication date: February 16, 2017Inventor: Juan Alvarez
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Patent number: 9428563Abstract: The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.Type: GrantFiled: February 18, 2014Date of Patent: August 30, 2016Assignee: Alkermes, Inc.Inventor: Juan Alvarez
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Publication number: 20160237132Abstract: The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.Type: ApplicationFiled: February 16, 2016Publication date: August 18, 2016Inventors: Juan Alvarez, Leslie A. McSweeney
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Publication number: 20160175458Abstract: The present invention provides novel, single chain Fc fusion proteins having improved properties. The invention provides single chain fusions of soluble proteins fused to the Fc region of an immunoglobulin via a novel linker comprising a constant region of an immunoglobulin light chain linked to a CH1 constant region of an immunoglobulin heavy chain. This novel linker confers favorable properties on the Fc fusion proteins of the invention such as improved bioactivity and increased half-life as compared to non-Fc fusion counterparts or as compared to prior art Fc fusion proteins. The novel Fc fusion protein scaffold as described herein may be designed to include soluble proteins of interest capable of binding or interacting with any target of interest. Preferably, the Fc fusion protein of the invention is a dimer. The dimer preferably forms via a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins of the invention.Type: ApplicationFiled: December 18, 2015Publication date: June 23, 2016Inventors: Juan Alvarez, Demetri T. Moustakas, Heather R. Brodkin, Leslie A. McSweeney
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Patent number: 9359415Abstract: The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.Type: GrantFiled: June 6, 2013Date of Patent: June 7, 2016Assignee: Alkermes, Inc.Inventors: Juan Alvarez, Jean Chamoun
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Patent number: 9296801Abstract: The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.Type: GrantFiled: June 6, 2013Date of Patent: March 29, 2016Assignee: Alkermes, Inc.Inventors: Juan Alvarez, Leslie A. McSweeney
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Publication number: 20160052983Abstract: The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g. pharmacokinetic and/or physicochemical properties) compared to the same active protein not linked to mucin-domain polypeptide, as well as methods for making and using the fusion proteins of the invention.Type: ApplicationFiled: September 1, 2015Publication date: February 25, 2016Inventors: Juan Alvarez, Jean Chamoun, Heather C. Losey
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Patent number: 9156897Abstract: The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g. pharmacokinetic and/or physicochemical properties) compared to the same active protein not linked to mucin-domain polypeptide, as well as methods for making and using the fusion proteins of the invention.Type: GrantFiled: June 6, 2013Date of Patent: October 13, 2015Assignee: Alkermes, Inc.Inventors: Juan Alvarez, Jean Chamoun, Heather C. Losey
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Publication number: 20150238974Abstract: The invention provides a separation system comprising a decanter, a supply tank, a first conduit between the decanter and supply tank, and an overflow reservoir in fluid communication with an upper portion of the decanter. Also provided is a method of separating particles. The method comprises providing a reservoir comprising a plurality of seeds in a liquid; providing an inlet flow of the fluid into the reservoir; adjusting the specific gravity of the liquid so that a first portion of the seeds float near the surface of the liquid and a second portion of the seeds sink near the bottom of the reservoir; providing an outlet flow of the fluid from a location proximal to the top of the reservoir, wherein the outlet flow removes the first portion of the seeds from the reservoir; and recycling the outlet flow of the fluid back to the inlet flow of the fluid. The system and method of the invention are particularly useful for separating seeds based on differences in specific gravity.Type: ApplicationFiled: January 26, 2015Publication date: August 27, 2015Inventors: Kenneth Chen-Ting Wang, Juan Alvarez
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Publication number: 20150210712Abstract: The present invention relates to compounds of Formula I:Type: ApplicationFiled: February 3, 2015Publication date: July 30, 2015Inventors: Laura Cook Blumberg, John A. Lowe, III, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan
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Patent number: 8969337Abstract: The present invention relates to compounds of Formula I:Type: GrantFiled: December 14, 2012Date of Patent: March 3, 2015Assignee: Alkermes Pharma Ireland LimitedInventors: Laura Cook Blumberg, John A. Lowe, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan
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Publication number: 20140234962Abstract: The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.Type: ApplicationFiled: February 18, 2014Publication date: August 21, 2014Applicant: Alkermes, Inc.Inventor: Juan Alvarez
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Publication number: 20130336925Abstract: The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.Type: ApplicationFiled: June 6, 2013Publication date: December 19, 2013Applicant: Alkermes, Inc.Inventors: JUAN ALVAREZ, LESLIE A. MCSWEENEY