Abstract: A multilayer stack comprises a surface wherein a predetermined region is defined for enclosing a device provided on the multilayer stack, the region being encircled by a welding zone defined on the surface, the welding zone being suitable for being welded by a welding radiation beam to a capping structure. It also comprises a first layer embedded within the multilayer stack, including at least one embedded component suitable for being functionally connected to the device provided on the multilayer stack. It furthermore comprises at least a second layer over the first layer comprising a shielding structure positioned between the at least one component of the first layer and the welding zone defined on the surface, the shielding structure being adapted to limit the welding depth of the welding radiation beam provided on the welding zone.

Abstract: A monitoring system for monitoring a kidney-related condition of a living creature. The monitoring system comprises an implantable sensor for repetitively measuring creatinine information in bodily tissue or bodily fluids of the living creature and for storing said creatinine information, and a processor programmed for determining, from the stored information, a kidney-related parameter for the living creature.

Abstract: A sensing system comprises a photonics integrated circuit partially encapsulated by an encapsulation material and the photonics integrated circuit comprising a first integrated sensor accessible to a target analyte and being positioned in a part of the photonics integrated circuit not being encapsulated by an encapsulation material, and a second integrated sensor accessible to a reference substance and being positioned in a part of the photonics integrated circuit that is encapsulated by an encapsulation material. The sensing system is further adapted to, when in use, comprise the reference substance but less or no target analyte between the second integrated sensor and the encapsulation material as compared to the amount of target analyte being present at the first integrated sensor.

Abstract: An implantable optical sensor (1) comprising a substrate (2) and at least one optical microstructure (3) for evanescent field sensing integrated with the substrate (2), the at least one optical microstructure (3) being positioned to form an optical interaction area (4) on a part of a surface (5) of the substrate (2), the optical assembly (1) further comprising a thin protective layer (6) covering at least the optical interaction area (4), the thin protective layer (6) being in a predetermined material with corrosion-protection characteristics and having a predetermined thickness, so as not to affect the evanescent field sensing.

Abstract: A method for encapsulating a sensing and/or actuator device, comprises the steps of providing a sensing and/or actuator device having a demarcation structure thereon. The sensing and/or actuator device comprises at least a substrate and a sensing and/or actuator element on the substrate. The demarcation structure contacts the substrate and defines an enclosed area of the substrate. The enclosed area comprises at least the sensing and/or actuator element. The method also comprises providing an encapsulation material outside the enclosed area, so the sensing and/or actuator element is left uncovered by the encapsulation material. The demarcation structure further comprises a capping structure overlaying the sensing and/or actuator element.

Abstract: A method for testing an optical assembly (1) which has an optical microstructure (3) integrated with a substrate (2). The optical microstructure (3) is positioned to form an external optical interaction area (4) on a part of a surface (5) of the substrate (2). A cover cap (6) seals at least a part of the surface (5) of the substrate (2) adjacent to the optical microstructure (3) to obtain a sealed cavity (9). An optical feedthrough (10) is integrated in the substrate (2) to form an external communication path from within the sealed cavity (9). The optical feedthrough (10) allows communication of a physical parameter value which is measured inside the sealed cavity (9) to outside the sealed cavity (9). The physical parameter value is associated with a measure of hermeticity of the sealed cavity (9).

Abstract: A battery housing for use in an active implantable medical device comprising a battery and a signal transferring element is described. The battery housing is adapted for holding the signal transferring element at a fixed position around the battery housing. A corresponding implantable device also is disclosed.

Abstract: A multilayer stack comprises a surface wherein a predetermined region is defined for enclosing a device provided on the multilayer stack, the region being encircled by a welding zone defined on the surface, the welding zone being suitable for being welded by a welding radiation beam to a capping structure. It also comprises a first layer embedded within the multilayer stack, including at least one embedded component suitable for being functionally connected to the device provided on the multilayer stack. It furthermore comprises at least a second layer over the first layer comprising a shielding structure positioned between the at least one component of the first layer and the welding zone defined on the surface, the shielding structure being adapted to limit the welding depth of the welding radiation beam provided on the welding zone.

Abstract: A health monitoring system for monitoring health of a living creature is described. The health monitoring system comprises an implantable sensor for simultaneously measuring a plurality of metabolism analytes in bodily tissue or bodily fluids of the living creature, thus obtaining a metabolic fingerprint for a living creature comprising concentration information of the plurality of metabolism analytes at a given moment in time. The health monitoring system furthermore comprises a processor programmed for determining for each of the plurality of metabolism analyte whether the obtained concentration information is within a predetermined range.

Abstract: A method for testing an optical assembly (1) which has an optical microstructure (3) integrated with a substrate (2). The optical microstructure (3) is positioned to form an external optical interaction area (4) on a part of a surface (5) of the substrate (2). A cover cap (6) seals at least a part of the surface (5) of the substrate (2) adjacent to the optical microstructure (3) to obtain a sealed cavity (9). An optical feedthrough (10) is integrated in the substrate (2) to form an external communication path from within the sealed cavity (9). The optical feedthrough (10) allows communication of a physical parameter value which is measured inside the sealed cavity (9) to outside the sealed cavity (9). The physical parameter value is associated with a measure of hermeticity of the sealed cavity (9).

Abstract: An implantable integrated sensor device comprises at least a first sensing element configured for sensing concentration levels of an analyte. The device also comprises an angiogenesis stimulating element for use in in vivo stimulation of angiogenesis by inducing or stimulating formation of vascular tissue in the surrounding tissue.

Abstract: A method for encapsulating a sensing and/or actuator device, comprises the steps of providing a sensing and/or actuator device having a demarcation structure thereon. The sensing and/or actuator device comprises at least a substrate and a sensing and/or actuator element on the substrate. The demarcation structure contacts the substrate and defines an enclosed area of the substrate. The enclosed area comprises at least the sensing and/or actuator element. The method also comprises providing an encapsulation material outside the enclosed area, so the sensing and/or actuator element is left uncovered by the encapsulation material. The demarcation structure further comprises a capping structure overlaying the sensing and/or actuator element.

Abstract: The present invention relates to a personal health monitoring system comprising an implantable sensor and a monitoring device. The present invention further relates to a multiple user health monitoring system comprising a plurality of such personal health monitoring systems. The present invention further relates to a method of monitoring the biological parameters of at least one user.

Abstract: An implantable optical sensor (1) comprising a substrate (2) and at least one optical microstructure (3) for evanescent field sensing integrated with the substrate (2), the at least one optical microstructure (3) being positioned to form an optical interaction area (4) on a part of a surface (5) of the substrate (2), the optical assembly (1) further comprising a thin protective layer (6) covering at least the optical interaction area (4), the thin protective layer (6) being in a predetermined material with corrosion-protection characteristics and having a predetermined thickness, so as not to affect the evanescent field sensing.

Abstract: A sensing system comprises a photonics integrated circuit partially encapsulated by an encapsulation material and the photonics integrated circuit comprising a first integrated sensor accessible to a target analyte and being positioned in a part of the photonics integrated circuit not being encapsulated by an encapsulation material, and a second integrated sensor accessible to a reference substance and being positioned in a part of the photonics integrated circuit that is encapsulated by an encapsulation material. The sensing system is further adapted to, when in use, comprise the reference substance but less or no target analyte between the second integrated sensor and the encapsulation material as compared to the amount of target analyte being present at the first integrated sensor.