Abstract: Provided are crystalline forms of pyrazine-2(1H)-ketone compound and a preparation method thereof; specifically disclosed are a method for preparing the compound of formula (II) and crystalline forms thereof.

Abstract: Disclosed are a crystal form of a thieno[2,3-c]pyridazine-4(1H)-one compound, a preparation method therefor and the use thereof in the preparation of a drug as an inhibitor of ACC1 and ACC2.

Abstract: Disclosed is a method for preparing a pyrrolidinyl urea derivative, which acts as a TrkA inhibitor, and further disclosed are an intermediate compound of a compound of formula (I) and a preparation method therefor.

Abstract: Provided are preparation methods for the chemical compound represented by formula (I) and an intermediate thereof.

Abstract: Provided are preparation methods for the chemical compound represented by formula (I) and an intermediate thereof.

Abstract: Provided are crystalline forms of pyrazine-2(1H)-ketone compound and a preparation method thereof; specifically disclosed are a method for preparing the compound of formula (II) and crystalline

Abstract: Disclosed is a total flavonoids extract of Gynura formosana Kitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract of Gynura formosana Kitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract of Gynura formosana Kitam. reaches 80%-85%.

Abstract: A total flavonoid extract from Gynura formosana Kitam., comprising 80-85% of rutin. A preparation method comprises selecting a complex enzyme consisting of a specific composition and ratio of enzymes for enzymatic hydrolysis, extracting and concentrating by a macroporous resin, and separating and purifying by a macroporous resin. The extract has therapeutic effect on non-alcoholic fatty liver disease.

Abstract: A total flavonoid extract from Gynura formosana Kitam., comprising 80-85% of rutin. A preparation method comprises selecting a complex enzyme consisting of a specific composition and ratio of enzymes for enzymatic hydrolysis, extracting and concentrating by a macroporous resin, and separating and purifying by a macroporous resin. The extract has therapeutic effect on non-alcoholic fatty liver disease.

Abstract: A total flavonoid extract from Gynura formosana Kitam., comprising, in weight percent, 80-85% of rutin. A method for preparing the total flavonoid extract from Gynura formosana Kitam. comprises solvent extraction, complex enzymatic hydrolysis, and separation and purification by a macroporous resin. The total flavonoid extract from Gynura formosana Kitam. is used to prepare a drug or health product related to alcoholic fatty liver disease.

Abstract: A display device system and a display device are disclosed. The display device system includes: a display device comprising an electrochromic pattern; a control circuit, one port of which is connected to the display device; a thermo-electric conversion film, one end of which is connected to the other port of the control circuit, and the other end of which is an end for connecting to an external electronic device; wherein the thermo-electric conversion film is configured to receive waste heat from the external electronic device and convert the waste heat to electrical energy for powering the control circuit, and the control circuit is configured to control change of the electrochromic pattern.

Abstract: The present disclosure provides a display panel, a display device and a display method. The display panel includes a base substrate, and an organic electroluminescent device layer, a detection sensor and a color switchable structure which are successively located on the base substrate and are insulated from each other, where the organic electroluminescent device layer includes a plurality of sub-pixels, and the color switchable structure includes sub-units disposed in one-to-one correspondence with the sub-pixels; the sub-units are configured to transmit light emitted by the sub-pixels under the control of applied different signals, or to display light of colors corresponding to the applied signals; and the detection sensor is configured to detect display parameters of the sub-pixels or the sub-units.

Abstract: A method for reducing training requirements for clinical trial staff including receiving clinical trial information for a clinical trial, wherein the clinical trial information includes one or more clinical trial tasks, one or more training units associated with at least one of the tasks, and clinical trial protocol requirements; providing a list of the clinical trial tasks to a user for selection, wherein the user is a member of the clinical trial staff; generating a training program for the user, comprising a plurality of assigned training units, wherein each of the assigned training units are associated with the selected clinical trial tasks; providing the assigned training units from the training program to the user for completion; documenting completion of the assigned training units; and documenting confirmation that the user is qualified for the clinical trial after completion of the assigned training units, wherein confirmation is provided by a principal investigator.

Abstract: Embodiments provide a full-linear model for the optimal power flow of an integrated power and natural-gas system based on a deep learning method, mainly comprising following steps of: 1) establishing an integrated power and natural-gas system and acquiring basic data of the integrated power and natural-gas system; 2) establishing a linear natural-gas model based on deep learning; and 3) based on the linear natural-gas model, establishing a full-linear model for the optimal power flow of the integrated power and natural-gas system. In the full-linear model for the optimal power flow of an integrated power and natural-gas system based on a deep learning method provided by the present invention, one-segment linearization is performed on a natural-gas pipeline model. Compared with the conventional segmented linear model, the method provided by the present invention can greatly improve the calculation efficiency.

Abstract: Disclosed is a total flavonoids extract of Gynura formosana Kitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract of Gynura formosana Kitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract of Gynura formosana Kitam. reaches 80%-85%.

Abstract: A total flavonoid extract from Gynura formosana Kitam., comprising, in weight percent, 80-85% of rutin. A method for preparing the total flavonoid extract from Gynura formosana Kitam. comprises solvent extraction, complex enzymatic hydrolysis, and separation and purification by a macroporous resin. The total flavonoid extract from Gynura formosana Kitam. is used to prepare a drug or health product related to alcoholic fatty liver disease.

Abstract: A total flavonoid extract from Gynura formosana Kitam., comprising 80-85% of rutin. A preparation method comprises selecting a complex enzyme consisting of a specific composition and ratio of enzymes for enzymatic hydrolysis, extracting and concentrating by a macroporous resin, and separating and purifying by a macroporous resin. The extract has therapeutic effect on non-alcoholic fatty liver disease.

Abstract: The present disclosure provides a display substrate, a manufacturing method thereof, a display panel, and a display device. The display substrate includes: a substrate; and a thin film transistor, provided on a first surface of the substrate and including an electrode and an insulating layer, the insulating layer covering the electrode, wherein a groove is formed on a surface of the insulating layer away from the electrode, and an orthogonal projection of a bottom wall of the groove on the substrate overlaps with an orthogonal projection of the electrode on the substrate. In the display substrate provided by the present disclosure, a surface of the insulating layer covering the electrode away from the substrate is planarized, so that the subsequently formed layer structures may have better flatness, and problems of faulting, fracturing and so on likely occurring when the display substrate is bent may be solved.

Abstract: The present disclosure provides a display substrate, a manufacturing method thereof, a display panel, and a display device. The display substrate includes: a substrate; and a thin film transistor, provided on a first surface of the substrate and including an electrode and an insulating layer, the insulating layer covering the electrode, wherein a groove is formed on a surface of the insulating layer away from the electrode, and an orthogonal projection of a bottom wall of the groove on the substrate overlaps with an orthogonal projection of the electrode on the substrate. In the display substrate provided by the present disclosure, a surface of the insulating layer covering the electrode away from the substrate is planarized, so that the subsequently formed layer structures may have better flatness, and problems of faulting, fracturing and so on likely occurring when the display substrate is bent may be solved.

Abstract: A method and device for determining static equivalences of distribution networks is provided. The method comprises: acquiring node admittance matrices related to a border node and a distribution network, power loss and a voltage value and a current value of the border node; constructing static equivalence determination conditions for determining static equivalences of the distribution network, comprising a consistency of sensitivity equation, a consistency of power loss equation, an equivalent network power balance equation and a Kirchhoff's current equation; and calculating static equivalent parameters according to the static equivalence determination conditions. The inventive method and device are simple and effective, where the consistency of sensitivity and power loss before and after equivalence are considered comprehensively, and where the distributed generators' voltage and power support characteristics in an active distribution network are reserved.