Abstract: A self contained multiple color writing pen has a single writing tip for dispensing a user selectable variable color ink to paper or other surfaces from an internal mixing chamber. Several internal ink reservoirs each having a different color ink, supply their ink to the mixing chamber. A user may easily change the selectable writing color even as he writes by manually moving a rotatable thumbwheel on the pen and the dispensed ink output changes quickly in response to such thumbwheel input. The number of colors selectable by a user is seemingly infinite and includes the entire color spectrum.

Abstract: The present invention comprises a children's copying machine for copying two- and three-dimensional objects. The copy machine includes a slidable art tray for receiving two dimensional objects and or creative drawing on an erasable surface. The art tray surface is supported on springs and depressible for further receiving three dimensional objects. Special effects are provided such as image storage into memory, combining of selected images for printing, warping of images and overlay functions. A spin tray is further incorporated into the art tray for providing rotational motion to objects during the copying process.

Abstract: A therapeutic compound of the chlorambucil family conjugated to two or three acyl groups derived from fatty acids. The compound has the following formula.

Abstract: The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably non-steroidal anti-infiammatory agents which include a carboxylic acid group. The compounds involve the use of tromethamine or ethanolamine derivative to link the acyl groups derived from fatty acids to the therapeutic compounds.

Abstract: A therapeutic compound of the chlorambucil family conjugated to two or three acyl groups derived from fatty acids. The compound has the following formula. in which X is chlorambucil, Y is an optional spacer group, AA is an amino acid, B is H or CH2O—R3, and n is a number from 0 to 3. X is linked to Y via the carboxyl group. R1, R2 and R3 are as defined by the present specification.

Abstract: Compositions, methods and devices for bioremediation that comprise components of constructed microbial mats with organic and inorganic materials are described. The compositions, methods and devices can be used for bioremediation of different individual contaminants and for mixed or multiple contaminants, and for production of beneficial compositions and molecules.

Abstract: Compositions and methods of use of constructed microbial mats, comprising cyanobacteria and purple autotrophic bacteria and an organic nutrient source, in a laminated structure, are described. The constructed microbial mat is used for bioremediation of different individual contaminants and for mixed or multiple contaminants, and for production of beneficial compositions and molecules.

Abstract: A methotrexate conjugated to 1-3 acyl groups derived from fatty acids. In particular the invention relates to altering the pharmacokinetic profile and mode of delivery of methotrexate by conjugating it to 1.2 or 3 acyl derivatives of fatty acids.

Abstract: The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably non.about.steroidal anti.about.inflammatory agents which include a carboxylic acid group. The compounds involve the use of tromethamine or ethanolamine derivative to link the acyl groups derived from fatty acids to the therapeutic compounds.

Abstract: Compositions and methods of use of constructed microbial mats, comprising cyanobacteria and purple autotrophic bacteria and an organic nutrient source, in a laminated structure, are described. The constructed microbial mat is used for bioremediation of different individual contaminants and for mixed or multiple contaminants, and for production of beneficial compositions and molecules.

Abstract: This invention relates to remedial bacterial systems in a constructive mat including ensiliaged material, particularly constructed mixed microbial mats for specific bioremedial applications. Preferably, the constructed mixed microbial mat comprises ensiled grass clippings with a cyanobacteria and a chemotrophic bacteria.