Patents by Inventor Judith Wardwell-Swanson

Judith Wardwell-Swanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying compounds that inhibit Notch cleavage
    Patent number: 7608408
    Abstract: In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying ?-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are provided. Also provided are methods of identifying compounds that inhibit cleavage of ?-secretase substrates other than Notch and homogeneous compositions or cultures of Notch-expressing cells that undergo mucin-2 or mucin-5AC induction in response to a compound known to inhibit Notch cleavage and methods of their generation.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: October 27, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Catherine Burton, Charles F. Albright, Judith A. Wardwell-Swanson
  • Methods of identifying compounds that inhibit Notch cleavage
    Publication number: 20070105161
    Abstract: In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying ?-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are provided. Also provided are methods of identifying compounds that inhibit cleavage of ?-secretase substrates other than Notch and homogeneous compositions or cultures of Notch-expressing cells that undergo mucin-2 or mucin-5AC induction in response to a compound known to inhibit Notch cleavage and methods of their generation.
    Type: Application
    Filed: November 10, 2006
    Publication date: May 10, 2007
    Inventors: Catherine Burton, Charles Albright, Judith Wardwell-Swanson
  • Modulators of the CLC-7 chloride channel and methods for their identification and use in the treatment and prevention of osteoporosis and related disease states
    Publication number: 20030215787
    Abstract: The present invention relates to compounds which act as modulators of the chloride channel CLC-7, assays for the identification of such compounds and methods of preventing, diagnosing, and treating osteoporosis and related disease states using such compounds.
    Type: Application
    Filed: January 23, 2003
    Publication date: November 20, 2003
    Inventors: Wen-Pin Yang, Anita C. Knapp-Ryseck, Yuli Wu, Jinwen Huang, Judith Wardwell-Swanson, Stephen Glenn Walker, Jian Chen, Stephen S. Kalinowski, Zelin Sheng, Samuel E. Hellings