Abstract: The present invention provides compositions and methods for the delivery of therapeutics to a cell or subject.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: The present invention is directed to ion-conducting, nitrile containing sulfonated polymeric materials formed by the direct polymerization of sulfonated monomers and aromatic nitrile monomers. These nitrile containing sulfonated polymers may be used to form membranes that have application in fuel cell and ion exchange technologies. In particular, the membranes may be used in hydrogen, direct methanol, reformate, and other direct oxidation fuel cells.

Abstract: A magnetic polymer may be polymerized in living tissue. Retinal detachment may now be repaired without needing suturing, by using a magnetic fluid with a magnetic scleral buckle. The magnetic scleral buckle may be polymerized into place in the eye, rather than being preformed outside the eye as has been conventionally done. Magnetic systems formed internally may be used in other medical contexts, such as in drug delivery.

Abstract: Oxidatively-stable, magnetic cobalt nanoparticles and other Group VIII nanoparticles are provided, and production methods. Poly(styrene-b-4-vinylphenoxyphthalonitrile) (a novel composition) or random graft copolymers containing phthalonitrile groups in the backbone are examples of compositions that may be complexed with cobalt or other Group VIII metals.

Abstract: A method for targeted delivery of therapeutic agents within the eye is provided. Magnetic particles having associated therapeutic agents are injected into the eye, for example into the vitreous cavity. External magnets are then used move the particles to a desired position within the eye, for example, to the macula. The therapeutic agent that is delivered may be, for example, anti-VEGF (for the treatment of exudative macular degeneration) or a steroid (for the treatment of diabetic retinopathy).