Abstract: The disclosed subject matter includes devices, methods, and systems for generating optical tomographic data including volumetric and surface geometric data. The disclosed subject matter also includes devices, methods, and systems for generating optical tomographic data for purposes of diagnosing rheumatoid arthritis.

Abstract: Optical diagnosis system for small animal imaging, in which the animal which has been arranged on a bearing plate and treated with an activatable optical contrast medium is irradiated by an excitation source and the resulting fluorescent radiation that is radiated back is detected by a detector system, in which case the bearing plate is designed as a radiation-transparent window (13) for a reference radiation—generated by a second marker of the contrast medium—for the detection of the initial concentration of the inert contrast medium.

Abstract: A large number of cells can be evaluated in terms of their reaction state with molecular reactants under near-field optical conditions in a measuring and evaluation procedure of the invention. Light sources of different aperture diameters in the nano- or micro-range are disposed in a sample platform. The 2D-nano-light source array is embodied by a plurality of near-field light sources which are arranged in mutually juxtaposed relationship in raster form and are excited jointly or in succession. The carrier material used is a semiconductor material.

Abstract: In a method and apparatus for determining the circumference of a finger or toe joint, in particular a proximal interphalangeal joint, to be evaluated in the context of an arthritis examination of an examination subject, the joint is irradiated using a light source and at least one two-dimensional projection image is recorded using a camera apparatus. From the projection image, the diameter of the joint is determined by means of an automatic edge detection method, and the circumference is calculated on the basis of the diameter. Additionally, a diaphanoscopic examination of the joint can be made with the same apparatus, and the results combined with the diameter information to identify or monitor a degree or progress of the inflamation.

Abstract: In a method and an apparatus for locating an examination size for diaphanoscopic examination of a living subject, a region of the living subject wherein the optimum examination location is suspected is sequentially transilluminated with radiation, preferably in a wavelength range of the optical tissue window, for registration of scattered light distributions in the form of location-related spread functions, particularly point spread functions, and at least one function-specific, location-related feature of each spread function is determined, based on which a position value defining the examination location is determined.