Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: A method for a method of prophylaxis and/or therapy of neurological conditions in a subject in need thereof includes the step of administrating a recombinant AAV vector to the subject. Also disclosed is the use of the a recombinant AAV vector in the manufacture of a medicament of prophylaxis and/or therapy of neurological conditions in a subject in need thereof. The recombinant AAV vector includes: PHP.eB; a sequence for introducing the expression of human M3 muscarinic DREADD receptor coupled to Gq (hM3Dq); and an inhibitory neuron-specific Distal-less homeobox (Dlx) gene enhancer sequence.

Abstract: A method of treating a subject suffering from mental disorder including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A method of treating a subject suffering from pain associated with nerve injury including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A pharmaceutical composition including the cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof as active ingredient, one or more antidepressant compounds, and a pharmaceutically acceptable excipient.

Abstract: A method of treating a subject suffering from epilepsy includes administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A pharmaceutical composition includes the cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof as active ingredient, one or more antiepileptic compounds, and a pharmaceutically acceptable excipient.

Abstract: A method of treating a subject suffering from mental disorder including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A method of treating a subject suffering from pain associated with nerve injury including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A pharmaceutical composition including the cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof as active ingredient, one or more antidepressant compounds, and a pharmaceutically acceptable excipient.

Abstract: A method of treating a subject suffering from epilepsy includes administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A pharmaceutical composition includes the cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof as active ingredient, one or more antiepileptic compounds, and a pharmaceutically acceptable excipient.

Abstract: An apparatus for assessing a person's hand strength including means for engaging the hand. The apparatus including means for determining the strength of the hand based on a twisting action with the hand of the engaging means relative to the determining means. The engaging means is connected to the determining means. A method for assessing a person's hand strength including the steps of gripping a first object having a first diameter with the hand by the person. There is the step of twisting the first object with the hand. There is the step of measuring torque with a torque sensor, connected to the first object, of the object as it is being twisted by the hand.

Abstract: An apparatus for assessing a person's hand strength including means for engaging the hand. The apparatus including means for determining the strength of the hand based on a twisting action with the hand of the engaging means relative to the determining means. The engaging means is connected to the determining means. A method for assessing a person's hand strength including the steps of gripping a first object having a first diameter with the hand by the person. There is the step of twisting the first object with the hand. There is the step of measuring torque with a torque sensor, connected to the first object, of the object as it is being twisted by the hand.