Patents by Inventor Juha Ala-Sorvari
Juha Ala-Sorvari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7294345Abstract: The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.Type: GrantFiled: January 14, 2004Date of Patent: November 13, 2007Assignee: Schering OyInventors: Timo Haapakumpu, Harri Jukarainen, Juha Ala-Sorvari, Henry Rankonen, Frederik E. Riphagen, Wolfgang Arnold
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Publication number: 20060067982Abstract: The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.Type: ApplicationFiled: January 14, 2004Publication date: March 30, 2006Applicant: TIMO HAAPAKUMPU HARRI JUKARA JUHA ALA -SORVARI HENInventors: Timo Haapakumpu, Harri Jukarainen, Juha Ala-Sorvari, Frederik Riphagen, Wolfgang Arnold
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Patent number: 6887948Abstract: The invention relates to a method for the preparation of a siloxane-based elastomer composition comprising at least one elastomer, said elastomer composition comprising poly(alkylene oxide) groups present in the elastomer as alkoxy-terminated grafts of polysiloxane units and linked to the polysiloxane units by silicon-carbon bonds wherein at least one vinyl functional polymer component is crosslinked in the presence of a peroxide catalyst.Type: GrantFiled: November 18, 2002Date of Patent: May 3, 2005Assignee: Schering OyInventors: Harri Jukarainen, Tommi Markkula, Juha Ala-Sorvari, Pirkko Lehtinen, Jarkko Ruohonen, Matti Lehtinen
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Publication number: 20040247674Abstract: A delivery system including at least one core and a membrane. The core and the membrane include an elastomer composition containing, e.g., poly(dimethylsiloxane), a siloxane-based elastomer having 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units and/or poly(alkylene oxide) groups, present as alkoxy-terminated grafts or blocks linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms. The delivery system is preferably an implant or an interuterine, intracervical or intravaginal system.Type: ApplicationFiled: March 12, 2004Publication date: December 9, 2004Inventors: Timo Haapakumpu, Juha Ala-Sorvari, Marko Aaltonen, Antti Keinanen, Manja Ahola
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Patent number: 6794464Abstract: A membrane or matrix for controlling the permeation rate of a drug, where the membrane or matrix includes a siloxane-based elastomer composition which contains at least one elastomer and optionally a non-crosslinked polymer. The elastomer composition includes poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present as blocks in a chain of the elastomer or the polymer, or as blocks and alkoxy-terminated grafts of polysiloxane units, the blocks or blocks and grafts being linked to the polysiloxane units by silicon-carbon bonds, with at least three blocks being present in the elastomer or polymer chain. Methods for the preparation of the elastomer composition are also disclosed.Type: GrantFiled: November 18, 2002Date of Patent: September 21, 2004Assignee: Schering OyInventors: Harri Jukarainen, Tommi Markkula, Juha Ala-Sorvari, Matti Lehtinen, Jarkko Ruohonen
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Publication number: 20030096921Abstract: The invention relates to a method for the preparation of a siloxane-based elastomer composition comprising at least one elastomer, said elastomer composition comprising poly(alkylene oxide) groups present in the elastomer as alkoxy-terminated grafts of polysiloxane units and linked to the polysiloxane units by silicon-carbon bonds wherein at least one vinyl functional polymer component is crosslinked in the presence of a peroxide catalyst.Type: ApplicationFiled: November 18, 2002Publication date: May 22, 2003Inventors: Harri Jukarainen, Tommi Markkula, Juha Ala-Sorvari, Matti Lehtinen, Pirkko Lehtinen, Jarkko Ruohonen
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Publication number: 20030096920Abstract: A membrane or matrix for controlling the permeation rate of a drug, where the membrane or matrix includes a siloxane-based elastomer composition which contains at least one elastomer and optionally a non-crosslinked polymer. The elastomer composition includes poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present as blocks in a chain of the elastomer or the polymer, or as blocks and alkoxy-terminated grafts of polysiloxane units, the blocks or blocks and grafts being linked to the polysiloxane units by silicon-carbon bonds, with at least three blocks being present in the elastomer or polymer chain. Methods for the preparation of the elastomer composition are also disclosed.Type: ApplicationFiled: November 18, 2002Publication date: May 22, 2003Inventors: Harri Jukarainen, Tommi Markkula, Juha Ala-Sorvari, Matti Lehtinen, Pirkko Lehtinen, Jarkko Ruohonen
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Patent number: 6476079Abstract: A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the core, where at least one of the core and membrane, when present, is made of a siloxane-based elastomer composition including at least one elastomer and optionally a non-crosslinked polymer. The device is characterized in that the elastomer composition includes poly(alkylene oxide) groups and that the poly(alkylene oxide) groups are present in the elastomer or polymer as alkoxy-terminated grafts of polysiloxane units, or as blocks, the grafts or blocks being linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms.Type: GrantFiled: December 23, 1999Date of Patent: November 5, 2002Assignee: Leiras OyInventors: Harri Jukarainen, Tommi Markkula, Juha Ala-sorvari, Matti Lehtinen, Jarkko Ruohonen
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Patent number: 6300452Abstract: The invention relates to a new polysiloxane-based block copolymer having a formula T(AB)xAT (I) wherein A=—(SiR′R″O)nSiR′R″—, wherein R′ and R″ are the the same or different and represent a lower alkyl group or a phenyl group, wherein said alkyl or phenyl group may be substituted or unsubstituted; B is polyalkylene oxide of formula wherein R is hydrogen, lower alkyl, or phenyl; R1 is hydrogen or lower alkyl; y is 2-6; m is 1-30; n is 1-3000; and x is 0-100.Type: GrantFiled: November 18, 1999Date of Patent: October 9, 2001Assignee: Leiras OyInventors: Harri Jukarainen, Jarkko Ruohonen, Matti Lehtinen, Juha Ala-Sorvari, Jukka Seppälä
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Patent number: 6299894Abstract: The invention relates to a delivery device for the controlled release of the therapeutically active agent gestodene, over a prolonged period of time, at a release rate of 0,1-300 &mgr;g/day, said device comprising a core comprising at least said therapeutically active agent, and a membrane encasing said core wherein said membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, and the release rate of said therapeutically active agent of said delivery device is regulated by the amount of said 3,3,3-trifluoropropyl groups.Type: GrantFiled: May 10, 2000Date of Patent: October 9, 2001Assignee: Leiras OyInventors: Tommi Markkula, Juha Ala-Sorvari, Harri Jukarainen, Matti Lehtinen, Jarkko Ruohonen
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Patent number: 6117442Abstract: The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially an androgen, over a prolonged period of time, said device including a core containing the therapeutically active agent, and a membrane encasing the core wherein the membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.Type: GrantFiled: November 12, 1998Date of Patent: September 12, 2000Assignee: Leiras OyInventors: Tommi Markkula, Juha Ala-Sorvari, Harri Jukarainen, Matti Lehtinen, Jarkko Ruohonen
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Patent number: 6056976Abstract: The invention relates to a siloxane-based elastomer intended for controlling the permeation of drugs, wherein the elastomer includes 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units.The invention relates also to a method for the preparation of a siloxane-based elastomer including 3,3,3,-trifluoropropyl substituents, where the elastomer is intended for controlling the permeation of drugs.In the method eitheri) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional crosslinking agent are crosslinked in the presence of a catalyst, orii) a 3,3,3,-trifluoropropyl-substituted polysiloxane component is crosslinked in the presence of a peroxide catalyst.Type: GrantFiled: November 12, 1998Date of Patent: May 2, 2000Assignee: Leiras OyInventors: Tommi Markkula, Juha Ala-Sorvari, Harri Jukarainen, Matti Lehtinen, Jarkko Rughonen