Abstract: An construction method of an embryonic chromosome signal library is provided. The construction method comprises obtaining an embryo and performing whole-genome amplification and next-generation sequencing to obtain a first chromosome signal; mapping the first chromosome signal to a chromosome reference signal to obtain a second chromosome signal; dividing the second chromosome signal within a predetermined interval range to obtain a third chromosome signal; and performing a regression correction on the sequencing read count (RC) of the third chromosome signal to obtain an embryonic chromosome signal library. Furthermore, a detection method and system of embryonic chromosomes are also provided. Thereby, the information comparison of the embryo chromosome signal library is used to determine whether the pre-implantation embryo is abnormal or not to achieve pre-implantation chromosome screening of pre-implantation embryos.

Abstract: An integral brush is formed by performing steps of tufts arrangement, tufts insertion into mold, mold turning and closing, and injection molding, thereby forming no gaps between cleaning assembly and handle. The cleaning assembly includes at least one cleaning unit each having a plurality of tufts integrally formed with one of a plurality of bases in the handle. The tufts are spaced apart and an upper portion of each tuft is shaped to form an uneven tip. The brush can increase a contact area between the cleaning assembly and an object so as to effectively clean the object.