Patents by Inventor Julia Alterman

Julia Alterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Branched oligonucleotides
    Patent number: 10478503
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: November 19, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 10435688
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: October 8, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20190247507
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 15, 2019
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20190225965
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: January 31, 2019
    Publication date: July 25, 2019
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • TWO-TAILED SELF-DELIVERING SIRNA
    Publication number: 20190024082
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Application
    Filed: June 22, 2018
    Publication date: January 24, 2019
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20180094263
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: September 6, 2017
    Publication date: April 5, 2018
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20170369882
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 28, 2017
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 9809817
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20170312367
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: January 30, 2017
    Publication date: November 2, 2017
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN mRNA
    Publication number: 20160355808
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: April 1, 2016
    Publication date: December 8, 2016
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20160319278
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: April 1, 2016
    Publication date: November 3, 2016
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman