Patents by Inventor Julian Solway

Julian Solway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REMODILINS FOR AIRWAY REMODELING AND ORGAN FIBROSIS
    Publication number: 20220177422
    Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 9, 2022
    Applicants: The University of Chicago, The United States of America,as Represented by the Secretary, Department of Health and Human Servic, President and Fellows of Harvard College, IIT Research Institute, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Julian SOLWAY, Nickolai DULIN, Diane Luci, David MALONEY, Chan Young PARK, Jeffrey FREDBERG, David MCCORMICK, Ramaswamy KRISHNAN
  • REMODILINS TO PREVENT OR TREAT CANCER METASTASIS, GLAUCOMA, AND HYPOXIA
    Publication number: 20220040207
    Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.
    Type: Application
    Filed: April 2, 2020
    Publication date: February 10, 2022
    Applicants: The University of Chicago, The United States of America as Represented by the Secretary Department of Health and Human Services, President and Fellows of Harvard College, IIT Research Institute, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Julian SOLWAY, Nickolai DULIN, Marsha ROSNER, Gokhan MUTLU, Diane LUCI, David MALONEY, Chan Young PARK, Jeffrey FREDBERG, David MCCORMICK, Ramaswamy KRISHNAN
  • DETERMINING RESPIRATORY PARAMETERS
    Publication number: 20160106341
    Abstract: A pulmonary measurement system includes a pulmonary measurement device that includes a mouthpiece with an airflow path and a sensor positioned in the airflow path; and a controller communicably coupled to the sensor. The controller includes a processor and instructions stored in memory and is operable to execute the instructions with the processor to perform operations including identifying a measurement from the sensor; identifying a particular equation stored in the memory, the particular equation developed using data analytics and including an input parameter that is based on the identified measurement; and based on the identified measurement and the particular equation, determining a value of absolute lung volume.
    Type: Application
    Filed: March 28, 2014
    Publication date: April 21, 2016
    Inventors: Ori Adam, Adam Laprad, Inon Cohen, Zachi Peles, Julian Solway, Jeffrey J. Fredberg
  • Promoter for smooth muscle cell expression
    Patent number: 7169764
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22? gene promoter as well as the murine cDNA and genomic SM22? nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22? promoter.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: January 30, 2007
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway
  • Promoter smooth muscle cell expression
    Patent number: 6331527
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22&agr; gene promoter as well as the murine cDNA and genomic SM22&agr; nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22&agr; promoter.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: December 18, 2001
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway
  • Method for promoting angiogenesis with a nucleic acid construct comprising an SM22&agr;0 promoter
    Patent number: 6297221
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22&agr; gene promoter as well as the murine cDNA and genomic SM22&agr; nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22&agr; promoter.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: October 2, 2001
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway
  • Promoter for smooth muscle cell expression
    Patent number: 6291211
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22&agr; gene promoter as well as the murine cDNA and genomic SM22&agr; nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22&agr; promoter.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: September 18, 2001
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway
  • Method for modulating smooth muscle cell proliferation
    Patent number: 6284743
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22&agr; gene promoter as well as the murine cDNA and genomic SM22&agr; nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22&agr; promoter.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: September 4, 2001
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway
  • Method for modulating smooth muscle cell proliferation
    Patent number: 6114311
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22.alpha. gene promoter as well as the murine cDNA and genomic SM22.alpha. nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22.alpha. promoter.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: September 5, 2000
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway
  • DNA constructs and viral vectors comprising a smooth muscle promoter
    Patent number: 6090618
    Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22.alpha. gene promoter as well as the murine cDNA and genomic SM22.alpha. nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22.alpha. promoter.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: July 18, 2000
    Assignee: Arch Development Corporation
    Inventors: Michael S. Parmacek, Julian Solway