Abstract: A method of treating an acute occlusion of the human vasculature as in stroke. The method includes providing a device flexible enough to be steered within the tortuous anatomy and still have the ability to be pushed across a thrombic occlusion. The device further provides two distinct sets of infusion lumens. The method includes advancing the device through the vasculature such that one infusion lumen is located distal to the thrombic occlusion and the other infusion lumen is located proximal to the occlusion. A neuroprotective drug is then infused through an opening distal to the occlusion and a thrombolytic agent infused through an opening proximal to the occlusion thereby dissolving the occlusion while minimizing damage to tissues distal to the occlusion.