Patents by Inventor Julie Carman

Julie Carman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to monitor pharmacodynamic responses mediated by in vivo administration of glucocorticoids
    Patent number: 11421278
    Abstract: The present invention relates generally to a method of monitoring pharmacodynamic responses mediated by in vivo administration of glucocorticoids. More specifically, the present invention relates to a method of using a change in gene signature as a pharmacodynamic marker of glucocorticoid exposure.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: August 23, 2022
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Julie Carman, Yanhua Hu
  • A METHOD TO MONITOR PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO ADMINISTRATION OF GLUCOCORTICOIDS
    Publication number: 20200299770
    Abstract: The present invention relates generally to a method of monitoring pharmacodynamic responses mediated by in vivo administration of glucocorticoids. More specifically, the present invention relates to a method of using a change in gene signature as a pharmacodynamic marker of glucocorticoid exposure.
    Type: Application
    Filed: August 28, 2018
    Publication date: September 24, 2020
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Julie CARMAN, Yanhua HU
  • POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS
    Publication number: 20100119509
    Abstract: The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
    Type: Application
    Filed: January 13, 2010
    Publication date: May 13, 2010
    Inventors: Julie Carman, Steven G. Nadler, Michael Bowen, Michael G. Neubauer, Pin Lu
  • Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    Patent number: 7670785
    Abstract: The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: March 2, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Julie Carman, Steven G. Nadler, Michael A. Bowen, Michael G. Neubauer, Pin Lu
  • Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    Publication number: 20090004184
    Abstract: The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
    Type: Application
    Filed: June 7, 2007
    Publication date: January 1, 2009
    Inventors: Julie Carman, Steven G. Nadler, Michael Bowen, Michael G. Neubauer, Pin Lu
  • Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    Patent number: 7244573
    Abstract: The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: July 17, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Julie Carman, Steven G. Nadler, Michael Bowen, Michael G. Neubauer, Pin Lu
  • Polynucleotides encoding novel guanylate binding proteins (GBP's)
    Patent number: 7226791
    Abstract: The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF-?B activity, guanylate binding activity and GTPase activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: June 5, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Julie Carman, Stephen J. Warner, Rolf-Peter Ryseck
  • Polynucleotides encoding novel guanylate binding proteins (GBP's)
    Publication number: 20050026191
    Abstract: The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF-?B activity, guanylate binding activity and GTPase activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: June 1, 2004
    Publication date: February 3, 2005
    Inventors: Julie Carman, Stephen Warner
  • Polynucleotides and polypeptides associated with the NF-kappaB pathway
    Publication number: 20040171823
    Abstract: The present invention relates to polynucleotide and polypeptide sequences newly identified as associated with the NF-&kgr;B pathway. The identification of such polynucleotides and polypeptides is an important advancement toward discovering and identifying new drug targets for the treatment of NF-&kgr;B pathway-related diseases, disorders, and conditions. The invention further relates to compositions and methods for the treatment of diseases or disorders associated with the NF-&kgr;B signaling pathway using the sequences of the invention.
    Type: Application
    Filed: January 13, 2004
    Publication date: September 2, 2004
    Inventors: Steven G. Nadler, Michael G. Neubauer, John N. Feder, Julie Carman
  • Polynucleotides and polypeptides associated with the NF-kB pathway
    Publication number: 20040086896
    Abstract: The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: May 7, 2003
    Publication date: May 6, 2004
    Inventors: Julie Carman, John N. Feder, Steven G. Nadler
  • Polynucleotides and polypeptides associated with the NF-kB pathway
    Publication number: 20030224486
    Abstract: The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 19, 2002
    Publication date: December 4, 2003
    Inventors: Julie Carman, Steven Nadler, John N. Feder
  • Polynucleotides and polypeptides associated with the development of osteoarthritis
    Publication number: 20030170743
    Abstract: The present invention is directed to polynucleotides encoding polypeptides associated with the development of osteoarthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of osteoarthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
    Type: Application
    Filed: December 3, 2002
    Publication date: September 11, 2003
    Inventors: Julie Carman, Steven G. Nadler, Michael Bowen, Michael G. Neubauer, Pin Lu
  • Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    Publication number: 20030170742
    Abstract: The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
    Type: Application
    Filed: December 3, 2002
    Publication date: September 11, 2003
    Inventors: Julie Carman, Steven G. Nadler, Michael Bowen, Michael G. Neubauer, Pin Lu