Abstract: The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.

Abstract: Presented herein are systems and methods for prediction of protein interfaces for binding to target molecules. In certain embodiments, technologies described herein utilize graph-based neural networks to predict portions of protein/peptide structures that are located at an interface of custom biologic (e.g., a protein and/or peptide) that is being designed for binding to a target molecule, such as another protein or peptide. In certain embodiments, graph-based neural network models described herein may receive, as input, a representation (e.g., a graph representation) of a complex comprising a target and a partially-defined custom biologic. Portions of the partially-defined custom biologic may be known, while other portions, such an amino acid sequence and/or particular amino acid types at certain locations of an interface, are unknown and/or to be customized for binding to a particular target.

Abstract: The need for a liquid detergent composition suitable for washing dishes, fitting both in-sink as well as direct application habits, which provides reduced smearing when used in direct application dishwashing methods, while having good suds mileage especially under in-sink application habit, and good viscosity, is met by formulating the liquid detergent composition to comprise a surfactant system, which comprises an alkyl sulfate anionic surfactant comprising C13 alkyl sulfate anionic surfactant, the C13 alkyl sulfate anionic surfactant comprising a specific fraction of 2-branched C13 alkyl sulfate anionic surfactant, with a specific distribution of the 2-branching.

Abstract: The need for a liquid hand-dishwashing composition which provides further improved sudsing volume and longevity when washing dishware using diluted liquid hand dishwashing compositions, especially in the presence of greasy soil and particulate soil, while still providing the desired cleaning, is met when the composition is formulated with a surfactant system comprising a specific level of alkyl sulfate surfactant and a co-surfactant, when the alkyl chain of the alkyl sulfate anionic surfactant has a mol fraction of C12 and C13 chains of at least about 50%, and the C13/C12 mol ratio of the alkyl chain is at least about 57/43.

Abstract: Speed reduction gear for an aircraft turbomachine. The reduction gear has a main axis and planet carrier having a cage and a cage carrier, a sun gear located in the cage and centred on the main axis, an annular row of planet gears arranged around the main axis and the sun gear and meshed with the sun gear, and a ring gear arranged around the axis and the cage and meshed with the planet gears. The cage and the cage carrier are connected to each other by connections whose bending flexibility is optimised.

Abstract: Method for checking the compliance of a workpiece, comprising the following steps: estimating a risk of non-compliance of characteristic on the basis of a law of probability associated with the characteristic; and verifying whether the estimated risk of non-compliance satisfies a decision criterion and, if so, declaring that the workpiece is compliant for characteristic; if not, measuring a value of the characteristic, determining whether or not the workpiece is compliant based on the measured value, and updating the law of probability associated with characteristic based on the measured value.

Abstract: Method for treating a liquid with a view to heating same, generating steam, developing a catalytic reaction and/or concentrating at least one species present therein, wherein a flow of a liquid is caused to circulate in at least one treatment area formed between at least two electrodes connected to an alternating current source with a phase alternation frequency greater than or equal to

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: The need for a hand-dishwashing composition which is highly effective at removing grease, while also having good suds mileage, and avoiding negatives on physical stability, especially at low temperatures is met by formulating the hand dishwashing composition to comprise a branched alkyl sulfate anionic surfactant having a low degree of alkoxylation, or no alkoxylation, and a co-surfactant, in combination with polypropylene glycol of a defined molecular weight, as described herein.

Abstract: An energy storage device for a motor vehicle includes a plurality of round cells for electrochemically storing energy, and a storage housing in which the plurality of round cells is provided. In the installed position, the round cells run substantially parallel to the vehicle transverse axis. The round cells are arranged within the storage housing in multiple layers in the direction of the vehicle vertical axis, wherein the number of layers varies in the direction of the vehicle longitudinal axis.

Abstract: A liquid hand dishwashing detergent composition having a higher fraction of components derived from natural, renewable sources is described. The liquid hand dishwashing detergent composition has a surfactant system which includes anionic surfactant having a combination of alkyl sulphate anionic surfactant and acyl taurate anionic surfactant.

Abstract: The present invention relates to a liquid hand dishwashing cleaning composition including a surfactant system, wherein the surfactant system includes an anionic surfactant and a co-surfactant, wherein the anionic surfactant includes a mixture of a linear anionic surfactant and a branched anionic surfactant with a defined degree of branching and with the branching predominantly on an unalkoxylated alkyl sulfate surfactant. Such compositions exhibit surprising and unexpected improved sudsing profile, preferably stable suds, especially when the manual dishwashing is performed in a sink full of water with the cleaning composition diluted in it.

Abstract: The present invention relates to a liquid hand dishwashing cleaning composition including a surfactant system, wherein the surfactant system includes an anionic surfactant and a co-surfactant, wherein the anionic surfactant includes a mixture of a linear anionic surfactant and a branched anionic surfactant with a defined degree of branching and with the branching predominantly on an unalkoxylated alkyl sulfate surfactant. Such compositions exhibit surprising and unexpected improved sudsing profile, preferably stable suds, especially when the manual dishwashing is performed in a sink full of water with the cleaning composition diluted in it.

Abstract: The present invention relates to a hand dishwashing cleaning composition including a surfactant system, wherein the surfactant system includes an anionic surfactant and a co-surfactant, wherein the anionic surfactant includes a mixture of a linear anionic surfactant and a branched anionic surfactant with a defined degree of branching on an alkyl ethoxy sulfate surfactant. Such compositions exhibit surprising and unexpected improved sudsing profile, preferably stable suds, especially when the manual dishwashing is performed in a sink full of water with the cleaning composition diluted in it.

Abstract: An energy storage device for a motor vehicle includes a plurality of round cells for electrochemically storing energy, and a storage housing in which the plurality of round cells is provided. In the installed position, the round cells run substantially parallel to the vehicle transverse axis. The round cells are arranged within the storage housing in multiple layers in the direction of the vehicle vertical axis, wherein the number of layers varies in the direction of the vehicle longitudinal axis.

Abstract: The need for a liquid hand-dishwashing composition which provides further improved sudsing volume and longevity when washing dishware using diluted liquid hand dishwashing compositions, especially in the presence of greasy soil and particulate soil, while still providing the desired cleaning, is met when the composition is formulated with a surfactant system comprising a specific level of alkyl sulfate surfactant and a co-surfactant, when the alkyl chain of the alkyl sulfate anionic surfactant has a mol fraction of C12 and C13 chains of at least about 50%, and the C13/C12 mol ratio of the alkyl chain is at least about 57/43.

Abstract: The need for liquid hand dishwashing cleaning compositions that comprise alkyl sulfate anionic surfactant having little or no ethoxylation, which provides improved low temperature stability while also achieving the desired product viscosity, suds mileage and overall cleaning is met by formulating the liquid hand dishwashing detergent composition to comprise branched alkyl sulfate anionic surfactant having a high level of non-C2-branching, especially with a specific alkyl branching distribution, and an average degree of alkoxylation of less than 0.5.

Abstract: The need for a liquid detergent composition comprising alkyl sulfate anionic surfactant which comprises little or no alkoxylation which provides a Newtonian viscosity profile over a larger shear rate range, and where the composition viscosity is less affected by changes in temperature, is met by formulating the liquid hand dishwashing detergent composition that comprises branched alkyl sulphate anionic surfactant with an average degree of alkoxylation of less than 0.5 and with the specific alkyl branching distribution as described herein, in combination with a co-surfactant selected from the group consisting of an amphoteric surfactant, a zwitterionic surfactant, and mixtures thereof, in the weight ratio of the anionic surfactant to the co-surfactant of from 2.0:1 to 8.0:1.

Abstract: The need for a liquid detergent composition comprising alkyl sulfate anionic surfactant which comprises little or no alkoxylation which provides a Newtonian viscosity profile over a larger shear rate range, and where the composition viscosity is less affected by changes in temperature, is met by formulating the liquid hand dishwashing detergent composition that comprises branched alkyl sulphate anionic surfactant with an average degree of alkoxylation of less than 0.5 and with the specific alkyl branching distribution as described herein, in combination with a co-surfactant selected from the group consisting of an amphoteric surfactant, a zwitterionic surfactant, and mixtures thereof, in the weight ratio of the anionic surfactant to the co-surfactant of from 2.0:1 to 8.0:1.

Abstract: The need for a hand-dishwashing composition which is highly effective at removing grease, while also having good suds mileage, and avoiding negatives on physical stability, especially at low temperatures is met by formulating the hand dishwashing composition to comprise a surfactant system, the surfactant system comprising an alkyl sulfate anionic surfactant comprising little or no branching and having a low degree of alkoxylation, or no alkoxylation, and a co-surfactant, in combination with polypropylene glycol of a defined molecular weight, as described herein.