Abstract: An acetabular reamer comprising: a body defining a rotation axis about which the acetabular reamer is rotatable; a reaming element movable between a reaming element inner position and a reaming element outer position relative to the body; an actuator for moving the reaming element between the reaming element inner and outer positions; and a reaming element lock configurable between a locked configuration and an unlocked configuration. In the unlocked configuration, the reaming element is freely movable by the actuator between the reaming element inner and outer positions. In the locked configuration, the reaming element lock prevents the reaming element from moving relative to the body. In use, when the reaming element lock is in the locked configuration and reaction forces are exerted onto the reaming element, a larger portion of the reaction forces is transmitted to the body than to the actuator.

Abstract: A acetabular reamer (10) for reaming an acetabulum, reaction forces being exerted onto the acetabular reamer by the acetabulum when the acetabulum is reamed, the acetabular reamer comprising: a body (12), the body (12) defining a rotation axis (13) about which the acetabular reamer (10) is rotatable; a reaming element (14, 14?, 14?) operatively coupled to the body (12) so as to be movable between a reaming element inner position and a reaming element outer position relatively thereto, the reaming element (14, 14?, 14?) being positioned further away from the rotation axis in the reaming element outer position than in the reaming element inner position; an actuator (16) operatively coupled to the reaming element (14, 14?, 14?) for moving the reaming element (14, 14?, 14?) between the reaming element inner and outer positions; and a reaming element lock (18) configurable between a locked configuration and an unlocked configuration, the reaming element lock (18) being operatively coupled to the reaming element (1

Abstract: The present invention relates to a non-viral novel drug delivery system. Nanoparticles comprising folic acid and chitosan are used to deliver a therapeutic agent of interest to the cell for various therapeutic applications.