Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Embodiments of the present disclosure relate to validation of unsupervised adaptive models. According to example embodiments of the present disclosure, unlike methods validating with the seen target data, the present disclosure synthesizes new samples by mixing the target samples and pseudo labels. The accuracy between model predictions of mixed samples and the mixed labels are measured for model selection, and the accuracy score may be called PseudoMix. PseudoMix enjoys the combined inductive bias of previous methods. Experiments demonstrate that PseudoMix can keep state-of-the-art performance across different validation settings.

Abstract: The present invention provides a display device and a brightness adjustment method of the display device. The display device includes a light-emitting surface, the display device includes a camera area and a display area, a display panel, and a light transmittance adjustment layer disposed on a side of the display panel close to the light-emitting surface. The light transmittance adjustment layer includes a first adjustment area corresponding to the camera area and a second adjustment area corresponding to the display area. In the present invention, a light transmittance of the first adjustment area and/or a light transmittance of the second adjustment area of the light transmittance adjustment layer is/are adjusted, so that a brightness of different areas of the light-emitting surface is kept uniformity.

Abstract: The present disclosure discloses a detector module, a detector, and a medical imaging apparatus. The detector module includes a detection unit, analog-to-digital conversion units, and a signal transmission unit. The detection module is configured to convert an optical signal into an analog signal. The analog-to-digital conversion units each configured to convert an analog signal into a digital signal. The signal transmission unit is disposed at a side of the detection unit in a first direction and includes at least one first circuit board and second circuit boards. Each of the at least one first circuit board is connected to the detection unit and a plurality of the second circuit boards. Each of the second circuit boards is connected to at least one of the analog-to-digital conversion units.

Abstract: Provided is a formation method of a semiconductor structure, including: providing a substrate having a first region and a second region, a plurality of discrete through holes being formed in the substrate, an arrangement density of the through holes in the first region being greater than that in the second region; forming a sacrificial layer filling the through holes; etching some thickness of the substrate around the sacrificial layer to form openings, the openings surrounding the sacrificial layer, a depth of the opening being less than a depth of the through hole in a direction perpendicular to a surface of the substrate; and removing the sacrificial layer, the openings communicating with the corresponding through holes to form trenches.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The present disclosure belongs to the technical field of wastewater treatment, and discloses an electrochemical nitrogen and phosphorus removal device and a method.

Abstract: The present disclosure discloses a tobacco leaf foliar spraying substance for reducing harmful ingredients in cheroot, a method for reducing carcinogenic components in flue-cured tobacco leaves and flue-cured tobacco shreds. The tobacco leaf foliar spraying substance contains a lotus leaf extract, the harmful chemical ingredients comprise N-nitrosonornicotine, 4-(N-methyl-nitrosamine)-1-(3-pyridinyl)-1-butanone, N-nitrosoanabasine and N-nitrosoanatabine. Foliar spraying is performed on a fertile field by using the lotus leaf extract before tobacco leaves are harvested and modulated, which not only significantly promotesagronomic characters and economic traits of tobacco and alleviates tobacco leaf browning but also effectively reduces harmful chemical ingredients unique to tobacco leaves, such as nitrosamine and nicotine.

Abstract: A method for carrying out grouting between adjacent gateroads in internal-staggered split-level coal mining. A return air gateroad of a stoping face and an inlet air gateroad of a heading face are not on the same level. The return air gateroad of the stoping face is arranged along a roof of a coal seam. The inlet air gateroad of the heading face is arranged along a floor of the coal seam. There is a height difference between the return air gateroad and the inlet air gateroad in a vertical direction. During the construction process, the inlet air gateroad is excavated at a delay distance of 180-200 meters from the return air gateroad. The drilling and grouting are performed while excavating the roadway, where grouting holes are arranged in a single row. A device for implementing the method is also provided.

Abstract: The invention relates to a wide spectrum multi-band detection structure with selective absorption enhancement and its preparation method. The structure comprises a plurality of sub-pixel units capable of detecting incident light in different bands. Each sub-pixel unit is composed of a square well-shaped microstructure array and a metal lower electrode (2), a photosensitive layer (3) and an upper electrode (4) on the surface thereof. The size and array spacing of square well-shaped microstructures in different sub-pixel units are determined according to the detection bands of the sub-pixel units where they are located. The upper openings of the square well-shaped microstructures are hollow to form a resonant cavity, and the adjacent square well-shaped microstructures in the same sub-pixel unit form a resonant cavity, thus solving the problem that the detector structure in the prior art cannot simultaneously realize visible light-near infrared multi-band absorption enhancement detection.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: A method for constructing a multiplex PCR library for high-throughput targeted sequencing: first acquiring a targeted DNA product by means of a high-specificity multiplex PCR reaction, and then digesting with a specific endonuclease, such that a specific molecular barcode is produced at the tail end of the PCR product; thus, the library construction process is more efficient, and the accuracy and sequencing depth of the obtained data are also ensured.

Abstract: The present disclosure relates to the field of biomedicine, in particular to the use of MCM8-cGAS-STING-IFN-I signal pathway as a disease target, including the use in the preparation of an animal model of a disease or the preparation of a product for the diagnosis, prevention, or treatment of a disease. In particular, the present disclosure comprises the use of a reagent for quantitatively detecting the gene expression or protein expression or protein activity of MCM8 in the preparation of a product for the diagnosis of a disease caused by dysfunctional mitophagy or caused by abnormal activation of cGAS-STING-IFN-I signaling pathway.

Abstract: The present disclosure provides a quantum dot particle aggregate and a preparation method therefor, a preparation method for a light conversion device, and quantum dot particles. The preparation method for the quantum dot particle aggregate includes: mixing a plurality of first polymer particles, a first quantum dot solution and a second polymer solution, and drying to obtain an aggregate containing a plurality of quantum dot particles A, where each of the quantum dot particles A includes a core of a first polymer particle and a shell of a second polymer formed by the second polymer, a plurality of first quantum dots are positioned in the shell of the second polymer, and the first polymer particle has a minimum dimension greater than or equal to 0.3 mm. The process reduces the damage to quantum dots and can prolong the life time of application products of quantum dots.

Abstract: A method includes receiving first data based on a region of interest of tissue. The first data may be captured to represent the tissue according to a first moment. The method also includes receiving second data based on the region of interest. The second data may be captured to represent the tissue according to a second moment different from the first moment. The method also includes determining features of the first data according to a first network. The first network may comprise weights. The method also includes determining features of the second data according to the weights. The method also includes determining an input based on the features of the first data and the features of the second data. The method may also include treating a patient or adjusting treatment of the patient diagnosed by one or more of these steps. An apparatus for performing the method is disclosed.

Abstract: Described herein are membrane puncturing devices used for endovascular surgery.

Abstract: A method for managing capacity of lithium ion battery is disclosed. A warning capacity D or C is preset for a discharge process or a charge process. Two anode active materials are mixed and used to form a lithium ion battery. The lithium ion battery is discharged or charged, during which the voltage of the battery is monitored. When the voltage of the lithium ion battery is in a range, a warning is generated for a remaining discharge capacity of the first lithium ion battery reaching the warning capacity D, or a charging capacity of the lithium ion battery reaching the warning capacity C.

Abstract: Disclosed is a daidzein derivative as represented by formula (I), or pharmaceutically acceptable salt thereof. Compared to the daidzein in the prior art, the daidzein derivative hydrochloride, in particular to the 7-O—N,N-diethyl-aminoacetyl daidzein hydrochloride, prepared by the daidzein derivative of the present invention, has better solubility and effect for treating cardiovascular diseases.

Abstract: Disclosed is a daidzein derivative as represented by formula (I), or pharmaceutically acceptable salt thereof. Compared to the daidzein in the prior art, the daidzein derivative hydrochloride, in particular to the 7-O—N,N-diethyl-aminoacetyl daidzein hydrochloride, prepared by the daidzein derivative of the present invention, has better solubility and effect for treating cardiovascular diseases.

Abstract: A key top member used in an input device includes a base sheet, a lower colored layer coated on the base sheet and coated with a transparent protecting layer thereon, an upper layer coated on the protecting layer, and a top layer coated on the upper layer. The top layer and the upper colored layer are pierced with open indicating an displaying symbol.