Abstract: Transmission information indicating transmittance of light of a printing medium used in image formation is acquired, a reduction ratio with respect to a maximum amount of mounted color materials used in the image formation is set based on the transmission information, and a fixing index indicating a fixing state of the color materials with respect to the printing medium is set based on the transmission information.

Abstract: This invention is to provide a technique of always obtaining a stable output image in image formation using toner. A supplier (1217) supplies toner in a decided toner supply amount. A developing device (1206) agitates the supplied toner and supplies the agitated toner to an electrostatic latent image formed on a photosensitive drum (1203), thereby developing a toner image on the photosensitive drum (1203). A correction amount calculation unit (1106) estimates the toner charge amount by calculating a function model that approximates the variation characteristic of the toner charge amount using the toner consumption necessary for printing a print target image, the toner supply amount necessary for printing the print target image, and the toner agitation time. At least one of an image processing condition and a process condition is controlled using the estimated toner charge amount.

Abstract: The power supply apparatus includes a switch element for turning ON and OFF supply of electric power to a primary winding of a transformer; a determining unit connected to an auxiliary winding of the transformer, for determining an ON-time of the switch element; and a switching unit for switching the ON-time determined by the determining unit.

Abstract: This invention is to provide a technique of always obtaining a stable output image in image formation using toner. A supplier (1217) supplies toner in a decided toner supply amount. A developing device (1206) agitates the supplied toner and supplies the agitated toner to an electrostatic latent image formed on a photosensitive drum (1203), thereby developing a toner image on the photosensitive drum (1203). A correction amount calculation unit (1106) estimates the toner charge amount by calculating a function model that approximates the variation characteristic of the toner charge amount using the toner consumption necessary for printing a print target image, the toner supply amount necessary for printing the print target image, and the toner agitation time. At least one of an image processing condition and a process condition is controlled using the estimated toner charge amount.

Abstract: An analyzer of the present invention for analyzing a glycan or a complex glycan includes a substrate, a fluorescent labeling excitation means and a fluorescent intensity measurement means. The substrate comprises a rectangle photoconductive base plate coated by a compound containing an active group to fix protein by an amino group thereof, one and more open-topped reaction vessel formed on a surface of the base plate, and plural spots of glycan binding proteins arranged in a matrix and immobilized on the surface of the base plate in the reaction vessel. The fluorescent labeling excitation means which excites fluorescent label by generating evanescent-waves on the surface of the substrate comprises a pair of optical fibers arranged toward the both side end faces of the right and left of the substrate to introduce a light thereinto.

Abstract: Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a kit thereof. In the method, a glycan biomarker consisting of a lectin WFA (Wisteria floribunda Agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma is used as a cancer marker to detect intrahepatic cholangiocarcinoma by detecting the cancer marker in a test specimen. The method for detecting intrahepatic cholangiocarcinoma can clearly differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma and enables early detection and determination with a performance clinically acceptable in terms of applicability, sensitivity and precision.

Abstract: An image forming apparatus, which is capable of bringing an output density close to a target density even if a charge amount of toner particles changes, includes an image forming unit having an image carrier and a developing unit, a storage unit storing a saturation charge amount of toner particles, and a control unit. The control unit forms a patch image using the image forming unit, measures the density of the patch image to obtain a first potential that is a contrast potential corresponding to a target density, estimates the charge amount of the toner particles in the developing unit to obtain a first charge amount, obtains a second potential from the first potential, the first charge amount and the saturation charge amount, and sets the second potential as the contrast potential.

Abstract: Disclosed is a novel lectin which can bind specifically to an L-fucose ?1?6 sugar chain. Also disclosed is use of the lectin. The L-fucose ?1?6 specific lectin of the present invention is characterized in that: (1) the lectin is extracted from a basidiomycete or an ascomycete; (2) the lectin has a molecular weight by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of 4,000 to 40,000; and (3) the lectin has an affinity to an L-fucose ?1?6 sugar chain, the affinity being represented by an association constant of 1.0×104M?1 or more (at 25 degrees C.). The lectin can be used for detecting an L-fucose ?1?6 sugar chain specifically, and is effective for the purification of an L-fucose ?1?6 sugar chain or a non L-fucose ?1?6 sugar chain.

Abstract: An image forming apparatus capable of stabilizing image density on a long-term basis by compensating for an error in prediction of toner particle charge amount, while reducing variation in image density on a short-term basis by the prediction. A CPU predicts an amount of electrostatic charge of toner particles in a developer container and sets an exposure condition and causes a toner image to be fixed on a recording medium and a pattern image for detecting image density, to be each formed on a photosensitive drum according to the set exposure condition, while performing gradation correction based on the gradation conversion table. The CPU updates the gradation conversion table such that a detected density of the pattern image becomes closer to a target density. The CPU sets the exposure condition based on a result of the prediction such that toner image density becomes constant.

Abstract: An image forming apparatus capable of performing both of stabilization of image density on a short-term basis and that on a long-term basis in a compatible manner. A CPU predicts an amount of electrostatic charge of toner particles in a developer container, sets a potential forming condition for image creation, and forms a toner image to be fixed on a recording medium, on a photosensitive drum according to the set potential forming condition. The CPU forms a pattern image for controlling a toner replenishment amount, on the photosensitive drum, under a potential forming condition which is set independently of the potential forming condition for image creation, and controls the amount of toner to be supplied to the developer container such that density of the pattern image, detected by an optical sensor, becomes equal to a target density.

Abstract: This invention is to provide a technique of always obtaining a stable output image in image formation using toner. A supplier (1217) supplies toner in a decided toner supply amount. A developing device (1206) agitates the supplied toner and supplies the agitated toner to an electrostatic latent image formed on a photosensitive drum (1203), thereby developing a toner image on the photosensitive drum (1203). A correction amount calculation unit (1106) estimates the toner charge amount by calculating a function model that approximates the variation characteristic of the toner charge amount using the toner consumption necessary for printing a print target image, the toner supply amount necessary for printing the print target image, and the toner agitation time. At least one of an image processing condition and a process condition is controlled using the estimated toner charge amount.

Abstract: The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.

Abstract: This invention provides an image forming apparatus capable of bringing the output density close to a target density even if the charge amount of toner particles changes. The image forming apparatus includes an image forming unit having an image carrier and a developing unit, a storage unit having the saturation charge amount of toner particles, and a control unit. The control unit forms a patch image using the image forming unit, measures the density of the patch image to obtain a first potential that is a contrast potential corresponding to a target density, estimates the charge amount of the toner particles in the developing unit to obtain a first charge amount, obtains a second potential from the first potential, the first charge amount and the saturation charge amount, and set the second potential as the contrast potential.

Abstract: Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a kit therefor. In the method, a glycan biomarker consisting of a lectin WFA (Wisteria floribunda Agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma is used as a cancer marker to detect intrahepatic cholangiocarcinoma by detecting the cancer marker in a test specimen. The method for detecting intrahepatic cholangiocarcinoma can clearly differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma and enables early detection and determination with a performance clinically acceptable in terms of applicability, sensitivity and precision.

Abstract: An image forming apparatus capable of making image quality more stable than in the prior art. An electrostatic latent image is formed on the surface of a photosensitive member based on an image signal. A developing device develops the electrostatic latent image on the photosensitive member by toner to thereby form a patch image. An optical sensor detects the density of the patch image. A toner charge amount is calculated from the density detected by the optical sensor, and a change in the toner charge amount is predicted based on a plurality of results of the calculation of the toner charge amount. The image forming apparatus generates a ?LUT for use in correcting the relationship between the image signal and the density based on the predicted change in the toner charge amount.

Abstract: An analyzer of the present invention for analyzing a glycan or a complex glycan includes a substrate, a fluorescent labeling excitation means and a fluorescent intensity measurement means. The substrate comprises a rectangle photoconductive base plate coated by a compound containing an active group to fix protein by an amino group thereof, one and more open-topped reaction vessel formed on a surface of the base plate, and plural spots of glycan binding proteins arranged in a matrix and immobilized on the surface of the base plate in the reaction vessel. The fluorescent labeling excitation means which excites fluorescent label by generating evanescent-waves on the surface of the substrate comprises a pair of optical fibers arranged toward the both side end faces of the right and left of the substrate to introduce a light thereinto.

Abstract: As a result of investigating the optimum conditions of methods for immobilizing proteins that interact with sugar chains onto a substrate, it was revealed that coating the surface of a slide glass with GTMS enables immobilization at a higher S/N ratio than conventionally possible. Moreover, by using a substrate to which a rubber with a number of holes was affixed to form a number of reaction vessels, and further by spotting lectins onto the substrate and washing with PBST, the weak interactions between sugar chains and lectins were successfully detected with improved sensitivity. In addition, by introducing an evanescent excitation-type scanner, it became possible to detect the interactions between lectins and sugar chains without washing away the probe solution.

Abstract: It is an object of the present invention to investigate what kinds of structures a sugar chain has by performing a sugar chain structural analysis of a glycoprotein produced in a transgenic silkworm. For the sugar chain of the glycoprotein produced in the transgenic silkworm, a glycoprotein having a sugar chain structure in which fucose is not linked to N-acetylglucosamine at a reducing terminal of the sugar chain is obtained. In addition, a glycoprotein having an almost completely humanized sugar chain structure is obtained by further integrating GalT gene into this transgenic silkworm.

Abstract: This invention is to provide a technique of always obtaining a stable output image in image formation using toner. A supplier (1217) supplies toner in a decided toner supply amount. A developing device (1206) agitates the supplied toner and supplies the agitated toner to an electrostatic latent image formed on a photosensitive drum (1203), thereby developing a toner image on the photosensitive drum (1203). A correction amount calculation unit (1106) estimates the toner charge amount by calculating a function model that approximates the variation characteristic of the toner charge amount using the toner consumption necessary for printing a print target image, the toner supply amount necessary for printing the print target image, and the toner agitation time. At least one of an image processing condition and a process condition is controlled using the estimated toner charge amount.

Abstract: Disclosed is a novel lectin which can bind specifically to an L-fucose ?1?6 sugar chain. Also disclosed is use of the lectin. The L-fucose ?1?6 specific lectin of the present invention is characterized in that: (1) the lectin is extracted from a basidiomycete or an ascomycete; (2) the lectin has a molecular weight by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of 4,000 to 40,000; and (3) the lectin has an affinity to an L-fucose ?1?6 sugar chain, the affinity being represented by an association constant of 1.0×104M?1 or more (at 25 degrees C.). The lectin can be used for detecting an L-fucose ?1?6 sugar chain specifically, and is effective for the purification of an L-fucose ?1?6 sugar chain or a non L-fucose ?1?6 sugar chain.