Patents by Inventor Jun-hong Min
Jun-hong Min has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7670772Abstract: Provided are a microfluidic chip for multiple bioassay and a method of manufacturing the same. The method includes: forming microfluidic channels by coupling a channel structure having grooves for sample channels and probe channels in a bottom surface and a substrate; forming probe immobilization regions at intersections between the probe channels and the sample channels; and forming blocking walls in the probe channels before and after each of the probe immobilization regions to prevent mixing of target sample. Since the probes are immobilized in the microfluidic channels after the formation of the microfluidic channels, difficulty in connecting fluidic channels after the immobilization of probes on a substrate can be removed. In addition, a microfluidic platform for a multiple bioassay into which a plurality of samples can be simultaneously loaded can be formed.Type: GrantFiled: January 20, 2006Date of Patent: March 2, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Joon-ho Kim, Jun-hong Min, Kyung-hwan Park, Soo-suk Lee, Hyun-gyu Park
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Patent number: 7659149Abstract: Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.Type: GrantFiled: February 2, 2006Date of Patent: February 9, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-tae Yoo, Sung-ouk Jung, Jun-hong Min, Ji-na Namgoong, Soo-hyung Choi, Jeo-young Shim
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Publication number: 20100021972Abstract: A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets.Type: ApplicationFiled: July 16, 2009Publication date: January 28, 2010Applicant: Samsung Electronics Co., Ltd.Inventors: Yoon-kyoung Cho, Joon-ho Kim, Kak Namkoong, Geun-bae Lim, Jun-hong Min
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Publication number: 20100015695Abstract: A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets.Type: ApplicationFiled: July 16, 2009Publication date: January 21, 2010Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Yoon-kyoung CHO, Joon-ho KIM, Kak NAMKOONG, Geun-bae LIM, Jun-hong Min
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Patent number: 7641858Abstract: An apparatus introducing a fluid using a centrifugal force includes an introduction member including a chip receiver and a fluid introduction reservoir, the chip receiver receiving a first part of a microfluidic chip, the first part including an inlet, the fluid introduction reservoir storing a fluid to be introduced to the microfluidic chip, the fluid introduction reservoir having an exit formed to correspond to the inlet of the microfluidic chip received in the chip receiver, and a support member supporting a second part of the microfluidic chip, wherein the microfluidic chip is disposed between the introduction member and the support member, the apparatus is rotatable in a state where the introduction member is closer to a center of rotation than the microfluidic chip, and the fluid is introducible from the fluid introduction reservoir through the inlet into the microfluidic chip due to a centrifugal force generated by rotation.Type: GrantFiled: August 29, 2007Date of Patent: January 5, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Young-rok Kim, Jun-hong Min, Kak Namkoong, Kwang-ho Cheong, Chang-eun Yoo, Ki-woong Han, Ki-eun Kim
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Patent number: 7598064Abstract: Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between the anode chamber and the cathode chamber, the anode chamber includes an inlet and an outlet for an anode chamber solution and an electrode, and the cathode chamber includes an inlet and an outlet for a cathode chamber solution and an electrode, and a method of electrochemically lysing cells using the same.Type: GrantFiled: January 6, 2009Date of Patent: October 6, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Hun-joo Lee, Joon-ho Kim, Chang-eun Yoo, Hee-kyun Lim, Kyu-youn Hwang, Soo-min Ma, Jun-hong Min
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Patent number: 7579172Abstract: An apparatus for amplifying nucleic acids includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate, wherein the reactant aqueous solution contacts the fluid to create a plurality of droplets surrounded by the fluid in the reaction vessel and the nucleic acids are amplified in the reactant aqueous solution droplets.Type: GrantFiled: March 3, 2005Date of Patent: August 25, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Yoon-kyoung Cho, Joon-ho Kim, Kak Namkoong, Geun-bae Lim, Jun-hong Min
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Patent number: 7572644Abstract: A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the hydrogel copolymer makes efficient removal of protein and high integration of nucleic acid and protein on a substrate for a microarray possible.Type: GrantFiled: January 17, 2006Date of Patent: August 11, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: In-ho Lee, Jun-hong Min, Su-hyeon Kim
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Publication number: 20090169431Abstract: Provided is a method of sensitively detecting nucleic acids in a nucleic acid sample, the method comprising: contacting the sample comprising the nucleic acid with a non-specific nucleic acid binding agent in an electrically conductive fluid medium; contacting the sample comprising the nucleic acid bound to the agent with a nanopore; and applying a voltage to the nanopore and monitoring a current change through the nanopore. The nucleic acid can be sensitively detected because a change in current amplitude through the nanopore is greater than when nucleic aid detection is performed without using an intercalator.Type: ApplicationFiled: February 2, 2009Publication date: July 2, 2009Applicant: Samsung Electronics Co., Ltd.Inventors: Kui-hyun Kim, Jun-hong Min, In-ho Lee, Ah-gi Kim
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Publication number: 20090170211Abstract: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.Type: ApplicationFiled: November 17, 2008Publication date: July 2, 2009Applicant: Samsung Electronics Co., Ltd.Inventors: Kyu-tae YOO, Joon-ho KIM, Jun-hong MIN, Sung-ouk JUNG, Ji-na NAMGOONG, Kui-hyun KIM, Jeo-young SHIM, Kak NAMKOONG
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Publication number: 20090159463Abstract: Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between the anode chamber and the cathode chamber, the anode chamber includes an inlet and an outlet for an anode chamber solution and an electrode, and the cathode chamber includes an inlet and an outlet for a cathode chamber solution and an electrode, and a method of electrochemically lysing cells using the same.Type: ApplicationFiled: January 6, 2009Publication date: June 25, 2009Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Hun-joo LEE, Joon-ho KIM, Chang-eun YOO, Hee-kyun LIM, Kyu-youn Hwang, Soo-min MA, Jun-hong Min
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Patent number: 7510865Abstract: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.Type: GrantFiled: February 3, 2006Date of Patent: March 31, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-tae Yoo, Joon-ho Kim, Jun-hong Min, Sung-ouk Jung, Ji-na Namgoong, Kui-hyun Kim, Jeo-young Shim, Kak Namkoong
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Patent number: 7504261Abstract: Provided is a method of sensitively detecting nucleic acids in a nucleic acid sample, the method comprising: contacting the sample comprising the nucleic acid with a non-specific nucleic acid binding agent in an electrically conductive fluid medium; contacting the sample comprising the nucleic acid bound to the agent with a nanopore; and applying a voltage to the nanopore and monitoring a current change through the nanopore. The nucleic acid can be sensitively detected because a change in current amplitude through the nanopore is greater than when nucleic aid detection is performed without using an intercalator.Type: GrantFiled: April 28, 2006Date of Patent: March 17, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Kui-hyun Kim, Jun-hong Min, In-ho Lee, Ah-gi Kim
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Patent number: 7488596Abstract: Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between the anode chamber and the cathode chamber, the anode chamber includes an inlet and an outlet for an anode chamber solution and an electrode, and the cathode chamber includes an inlet and an outlet for a cathode chamber solution and an electrode, and a method of electrochemically lysing cells using the same.Type: GrantFiled: December 15, 2005Date of Patent: February 10, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Hun-joo Lee, Joon-ho Kim, Chang-eun Yoo, Hee-kyun Lim, Kyu-youn Hwang, Soo-min Ma, Jun-hong Min
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Patent number: 7465545Abstract: Provided are a microfluidic chip and a microfluidic manipulating apparatus including the same. The microfluidic chip includes at least one microfluidic manipulating unit formed in a substrate. The microfluidic manipulating unit includes: a plurality of microchannels formed in the substrate; an inlet formed at a first end of the microchannel and exposed through the substrate; a trap formed at the microchannel; a chamber connected to a second end of the microchannel; and an outlet connected to the chamber and exposed through the substrate.Type: GrantFiled: January 27, 2006Date of Patent: December 16, 2008Assignee: Samsung Electronics Co., Ltd.Inventors: Su-hyeon Kim, Jun-hong Min, Kak Namkoong
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Publication number: 20080072994Abstract: An apparatus introducing a fluid using a centrifugal force includes an introduction member including a chip receiver and a fluid introduction reservoir, the chip receiver receiving a first part of a microfluidic chip, the first part including an inlet, the fluid introduction reservoir storing a fluid to be introduced to the microfluidic chip, the fluid introduction reservoir having an exit formed to correspond to the inlet of the microfluidic chip received in the chip receiver, and a support member supporting a second part of the microfluidic chip, wherein the microfluidic chip is disposed between the introduction member and the support member, the apparatus is rotatable in a state where the introduction member is closer to a center of rotation than the microfluidic chip, and the fluid is introducible from the fluid introduction reservoir through the inlet into the microfluidic chip due to a centrifugal force generated by rotation.Type: ApplicationFiled: August 29, 2007Publication date: March 27, 2008Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Young-rok KIM, Jun-hong MIN, Kak NAMKOONG, Kwang-ho CHEONG, Chang-eun YOO, Ki-woong HAN, Ki-eun KIM
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Publication number: 20070275435Abstract: Disclosed herein are a cell culture chip for monitoring a cell culture in real time and a method of monitoring the cell culture using the cell culture chip. The cell culture chip includes a cell culture chamber formed by side walls of a non-conductive material and a bottom layer of an insulating material and capable of accommodating a cell culture media. The cell culture chip also includes a semiconductor layer disposed under the bottom layer, a metal layer disposed under the semiconductor layer, and an electrode disposed in the cell culture chamber. The cell culture chip monitors both the states of cells attached to walls of the cell culture chamber and the states of cells floating in the cell culture media.Type: ApplicationFiled: January 23, 2007Publication date: November 29, 2007Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Kui-hyun KIM, Jung-im HAN, Jun-hong MIN, Kwang-ho CHEONG, Byung-chul KIM
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Publication number: 20070269819Abstract: A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the interior surface of the micro chamber; and performing a polymerase chain reaction (PCR) by adding a PCR mixture to the chamber. Since the nucleic acid is reversibly bound to the interior surface of the micro chamber, PCR yield is higher compared with a surface of aluminum oxide in which irreversible binding occurs. In addition, all processes are sequentially performed in a single micro chamber so that the number of samples, consumables, time, and labor for treatment and analysis can be reduced, detection sensitivity can be improved, and risk of sample cross contamination significantly reduced without sample loss by eliminating transporting of the sample.Type: ApplicationFiled: January 8, 2007Publication date: November 22, 2007Applicant: SAMSUNG ELECTRONICS CO., LTDInventors: Young-rok KIM, Jun-hong MIN, In-ho LEE, Young-sun LEE, Chang-eun YOO, Ki-woong HAN
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Publication number: 20070238109Abstract: Provided is a method of purifying nucleic acid, the method including: contacting a nucleic acid-containing sample and a solution containing a kosmotropic salt on a solid support having a hydrophilic functional group on its surface to bind the nucleic acid to the solid support. Since the solid support is used as it is without any surface treatment, manufacture of the apparatus is very easy, and nucleic acid can be bound to the solid support without specific additives in a wide pH range, so that the apparatus can be used for a Lab-On-a-Chip.Type: ApplicationFiled: October 27, 2006Publication date: October 11, 2007Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jun-hong MIN, In-ho LEE, Chang-eun YOO, Ki-woong HAN, Young-rok KIM
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Publication number: 20070238598Abstract: An apparatus and method for centrifugally separating particles by both weight and size include a rotating drum rotating about a second rotating axis disposed perpendicularly to a first rotating axis, and includes an inlet, at least one rotating plate and an outlet. The inlet injects a test material. The rotating plate extends radially outward toward an inner surface of the rotating drum from the second rotating axis and has one or more configurations of protruded and recessed portions formed on a surface thereof. The rotating plate receives the test material on a surface thereof. The outlet discharges separated test material.Type: ApplicationFiled: March 6, 2007Publication date: October 11, 2007Applicant: SAMSUNG ELECTRONICS CO., LTDInventors: Young-rok KIM, Kak NAMKOONG, Jun-hong MIN