Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: The present invention relates to a sulfur-containing positive electrode material for a secondary battery, a preparation method thereof, and a secondary battery. The sulfur-containing positive electrode material is obtained by uniformly mixing microporous polyacrylonitrile (with a pore diameter of 0.2-2 nm) as a precursor with elemental sulfur and then performing heating treatment. The microporous polyacrylonitrile is obtained through free radical polymerization of an acrylonitrile monomer and a crosslinking agent.

Abstract: A gel composition, in particular a gelled electrolyte, comprising: i) fumed alumina particles, wherein the mean primary particle size of the particle is from 5 to 50 nm and the BET specific surface area is from 40 to 400 m2/g; ii) at least two organic solvents; and iii) a lithium salt; wherein the amount of the alumina particles is 0.2-10% by weight based on the total weight of the gel composition. A method to prepare a gelled electrolyte, a Li-ion battery, a Li-ion battery and a device are also provided.

Abstract: A high-conductivity sulfur-based positive electrode material for a secondary battery and a secondary battery are provided. The sulfur-based positive electrode material is formed by evenly mixing highly isotactic polyacrylonitrile as a precursor with elemental sulfur and then heating to undergo a chemical reaction. The highly isotactic polyacrylonitrile is synthesized from an acrylonitrile monomer by means of a free radical polymerization or inclusion polymerization reaction under the action of a template agent.

Abstract: Systems, apparatuses, and methods for prefetching data by a display controller. From time to time, a performance-state change of a memory are performed. During such changes, a memory clock frequency is changed for a memory subsystem storing frame buffer(s) used to drive pixels to a display device. During the performance-state change, memory accesses may be temporarily blocked. To sustain a desired quality of service for the display, a display controller is configured to prefetch data in advance of the performance-state change. In order to ensure the display controller has sufficient memory bandwidth to accomplish the prefetch, bandwidth reduction circuitry in clients of the system are configured to temporarily reduce memory bandwidth of corresponding clients.

Abstract: A display system modifies display cycles of one or more displays to perform a system operation while avoiding visual perturbations at the one or more displays. The display system modifies, synchronizes, or both, blanking periods of the one or more displays such that blanking periods equal or exceed a blackout duration and overlap for at least the blackout duration. Then the system performs the system operation during an overlapping portion of the one or more blanking periods, where the system operation reduces availability of display data at the one or more displays.

Abstract: Systems, apparatuses, and methods for prefetching data by a display controller. From time to time, a performance-state change of a memory are performed. During such changes, a memory clock frequency is changed for a memory subsystem storing frame buffer(s) used to drive pixels to a display device. During the performance-state change, memory accesses may be temporarily blocked. In order to reduce visual artifacts that may occur while the memory accesses are blocked, a memory subsystem includes a control circuit configured to enable a caching mode which caches display data provided to the display controller. Subsequent requests for display data from the display controller are then serviced using the cached data instead of accessing memory.

Abstract: A method for repairing an ultra-thin structure by additive manufacturing by removing a damaged region of an ultra-thin structure by machining; acquiring a three-dimensional model of a region to be repaired; processing the three-dimensional model; constructing a powder carrying device on the periphery of the bottom of the region to be repaired, and allowing powder in the powder carrying device to be filled until flush with or tangent to the surface of the bottom of the region; melting, sintering or curing the powder around the outer contour of the ultra-thin structure by a high-energy beam or an auxiliary heating device, and combining the powder with the outer contour of the ultra-thin structure to form an outer contour thickened structure so as to form a flexible fixture; and repairing the region to be repaired by additive manufacturing technology according to a planned path obtained from the model processing.

Abstract: Provided are an electromagnetic heating device, a noise suppression method, a heating control system, and a storage medium, which relate to the field of electromagnetic heating technologies. The noise suppression method includes: in response to determining that any two adjacent heating modules of the electromagnetic heating device operate successively, obtaining a start operating frequency of the last-started heating module of the two adjacent heating modules; and adjusting an operating frequency of the first-started heating module of the two adjacent heating modules based on the start operating frequency of the last-started heating module, to allow the two adjacent heating modules to operate synchronously at a same operating frequency when the last-started heating module starts operating.

Abstract: Provided is a cookware detection circuit using half-bridge drive heating, a heating device, a cookware detection method, and a storage medium. The cookware detection circuit using half-bridge drive heating includes a control module (100) and a pulse cookware detection module (300). The control module is configured to output a single pulse cookware detection signal to a half-bridge drive module (200) of the electromagnetic heating device to drive a coil disk (204) to perform a resonant operation through the half-bridge drive module (200). A pulse detection module (300) is connected to the coil disk (204) and configured to detect a resonant current of the coil disk (204) and generate pulse signals based on the resonant current of the coil disk (204). The control module (100) is connected to the pulse detection module (300), and is further configured to count the pulse signals and determine whether cookware is placed on the electromagnetic heating device based on the number of the pulse signals.

Abstract: An electromagnetically heated cooking utensil, and a heating control circuit and method therefor. The heating control circuit includes a first resonance device; a second resonance device; a first power switch; a second power switch; a first synchronization device that detects voltages of both ends of the first resonance device to output a first synchronization signal; a second synchronization device that detects voltages of both ends of the second resonance device to output a second synchronization signal; and a control device that selects, according to the heating mode of the electromagnetically heated cooking utensil, the first synchronization signal to generate a driving signal for driving the first power switch, a second synchronization signal to generate a driving signal for driving the second power switch.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: A display system modifies display cycles of one or more displays to perform a system operation while avoiding visual perturbations at the one or more displays. The display system modifies, synchronizes, or both, blanking periods of the one or more displays such that blanking periods equal or exceed a blackout duration and overlap for at least the blackout duration. Then the system performs the system operation during an overlapping portion of the one or more blanking periods, where the system operation reduces availability of display data at the one or more displays.

Abstract: A magnetic resonance imaging (MRI) contrast agent and a preparation method and a use thereof is provided, which belong to the technical field of Magnetic Resonance Imaging contrast agent. The MRI contrast agent is prepared by the compound having a structure of formula I; and it also may include the compound having a structure of formula II or a pharmaceutically acceptable salt thereof, wherein M1 is a divalent ion or a trivalent ion of a paramagnetic metal selected from Mn, Fe, Eu, or Dy; M2 is selected from Na+, K+ or meglumine cation; when M1 is a divalent ion, a is 2; when M1 is a trivalent ion, a is 3. The MRI contrast agent has good water solubility, high relaxivity, and low toxic and side effect.

Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.

Abstract: The pot cover assembly includes a pot cover body and a spill-proof detection device. The spill-proof detection device is a capacitive detection device and it is provided on the pot cover body. At least a lower surface of the spill-proof detection device forms a detection plane and a capacitance value of the spill-proof detection device is changed as a function of a contact medium of the detection plane.

Abstract: A power coupler includes an input end assembly and an output end assembly separably coupled to the input end assembly. The input end assembly includes an input end base including a slot, a sealing cover arranged at the input end base, an input conductive member arranged at the input end base and connected to an external power supply, and a self-locking structure. The sealing cover is movable between a closing position to cover a slot port of the slot and an opening position to at least partially open the slot port. The self-locking structure is switchable between a locked state to limit the sealing cover from moving towards the opening position and an unlocked state to not limit the sealing cover. The output end assembly includes an output conductive member configured to extend into the slot and be connected to the input conductive member.