Abstract: An object of the present invention is to elucidate the onset mechanism of MSA through specification of a causative gene of it and further, to find a treatment method of it. The present invention provides a method for testing a multiple system atrophy risk of a test subject including a step of detecting a variant that deteriorates the biosynthesis of coenzyme Q10 in a sample collected from the test subject. Examples of the variant that deteriorates the biosynthesis of coenzyme Q10 include variants that suppress the expression or function of coenzyme Q2.

Abstract: Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.

Abstract: Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.

Abstract: Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.

Abstract: Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.

Abstract: Front vehicle body structure includes left and right front side frames, a subframe provided on the undersides of the side frames, and left and right mounting brackets for connecting the side frames and subframe. Engine-transmission unit is mounted on the subframe. Respective rear half portions of the side frames extend toward the rear of the vehicle body while gradually approaching the centerline of the vehicle body. Left and right mounting brackets are provided, on the respective rear half portions, to project toward the centerline. The left and right mounting brackets are detachably connected to the subframe. When an impact load greater than a predetermined intensity has been applied, the left and right mounting brackets are detached from the subframe and then squashed by the engine-transmission unit while effectively absorbing the impact.

Abstract: A vehicle front body structure includes a hollow front side frame of closed cross-sectional structure having a wheel relief portion having a horizontal width reducing to allow swivel movement of a front wheel of the vehicle. The wheel relief portion has a pair of reinforcement beads extending in a longitudinal direction of the vehicle and projecting from an outer sidewall and an inner sidewall, respectively, of the front side frame into an internal space of the hollow front side frame. The reinforcement beads have top surfaces being in abutment with each other and firmly fixed together.

Abstract: Front vehicle body structure includes left and right front side frames, a subframe provided on the undersides of the side frames, and left and right mounting brackets for connecting the side frames and subframe. Engine-transmission unit is mounted on the subframe. Respective rear half portions of the side frames extend toward the rear of the vehicle body while gradually approaching the centerline of the vehicle body. Left and right mounting brackets are provided, on the respective rear half portions, to project toward the centerline. The left and right mounting brackets are detachably connected to the subframe. When an impact load greater than a predetermined intensity has been applied, the left and right mounting brackets are detached from the subframe and then squashed by the engine-transmission unit while effectively absorbing the impact.

Abstract: A vehicle front body structure includes a hollow front side frame of closed cross-sectional structure having a wheel relief portion having a horizontal width reducing to allow swivel movement of a front wheel of the vehicle. The wheel relief portion has a pair of reinforcement beads extending in a longitudinal direction of the vehicle and projecting from an outer sidewall and an inner sidewall, respectively, of the front side frame into an internal space of the hollow front side frame. The reinforcement beads have top surfaces being in abutment with each other and firmly fixed together.

Abstract: A vehicle body structure comprises: a side roof rail, a rear roof rail, and a rear pillar, which are disposed in the rear portion of an vehicle body, and which intersect each other at an intersecting portion; a rear door provided for optionally opening and closing a rear port of the vehicle body; an automatic opening and closing unit disposed inside the vehicle body and in the vicinity of the intersecting portion; an aperture provided in the intersecting portion; and an arm provided through the aperture for connecting the automatic opening and closing unit to the rear door. The automatic opening and closing unit is fixed to at least the side roof rail, the rear roof rail, and the rear pillar so as to pass above the aperture.

Abstract: A vehicle body structure comprises: a side roof rail, a rear roof rail, and a rear pillar, which are disposed in the rear portion of an vehicle body, and which intersect each other at an intersecting portion; a rear door provided for optionally opening and closing a rear port of the vehicle body; an automatic opening and closing unit disposed inside the vehicle body and in the vicinity of the intersecting portion; an aperture provided in the intersecting portion; and an arm provided through the aperture for connecting the automatic opening and closing unit to the rear door. The automatic opening and closing unit is fixed to at least the side roof rail, the rear roof rail, and the rear pillar so as to pass above the aperture.

Abstract: An insecticidal compound of the formula ##STR1## wherein A completes a 5 or 6 membered aromatic ring selected from the group pyridyl, pyridyl substituted with C.sub.1-5 alkyl, C.sub.1-5 haloalkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, C.sub.1-5 alkylsulfonyl, cyano, halogen, phenoxy or C.sub.1-5 dialkylamino, pyrazinyl, pyrazinyl substituted with C.sub.1-5 alkyl or halogen, pyrazolyl substitited with C.sub.1-5 alkyl, pyridazyl substituted with halogen, or thiazolyl substituted with halogen or C.sub.1-5 alkyl;R.sub.1 is hydrogen or C.sub.1-5 alkyl, C.sub.1-5 haloalkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, C.sub.1-5 alkylsulfonyl, cyano, halogen, phenoxy, or C.sub.1-5 dialkylamino;X is substituted or unsubstituted C.sub.1-3 alkylene or C.sub.1-3 alkylidene;R.sub.2 is hydrogen, monoalkylcarbamoyl, C.sub.1-5 dialkylcarbamoyl, C.sub.1-5 alkoyl, C.sub.1-5 alkyl substituted with halogen, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, C.sub.1-5 alkoxycarbonyl, cyano, aryl, haloaryl, C.sub.

Abstract: The present invention relates to a compound having the formula below which has an excellent inseciticidal activity: ##STR1## wherein R.sub.1 represents an optionally substituted 5-6 membered aromatic hetero ring containing nitrogen atom, except a non-substituted 2-pyridyl; x represents an optionally substituted C.sub.1-3 alkyleneR.sub.2 represents a hydrogen, a carbamoyl, a mono or di C.sub.1-5 alkyl carbamoyl, a thiocarbamoyl, a mono or di C.sub.1-5 alkylthiocarbamoyl, a sulfamoyl, a mono or di C.sub.1-5 alkylsulfamoyl, an optionally substituted C.sub.1-5 alkyl, an optionally substituted C.sub.2-5 alkenyl, an optionally substituted C.sub.2-5 alkynyl, an optionally substituted C.sub.3-8 cycloalkyl, an optionally substituted C.sub.3-8 cycloalkenyl, an optionally substituted aryl or --Y--R.sub.5 ;Y represents O, S(O).sub.n, CO, CS or CO.sub.2 ;n represents 0, 1 or 2;R.sub.5 represents a hydrogen, an optionally substituted C.sub.1-5 alkyl, an optionally substituted C.sub.2-5 alkenyl, an optionally substituted C.