Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Disclosed is a circuit for shifting a fixed ground level to a floating ground level in a motor drive system, including a floating ground high level line, a floating ground output level line, a floating ground low level line, a normal input level line, and a normal ground line that are used for characterizing an application detail. The circuit includes a controlled switching current source, a first upper current rectifier, a second upper current rectifier, a lower current rectifier, and an amplifying and shaping circuit that are integrated on a same substrate.

Abstract: Disclosed is a circuit for converting a temperature change amount into a voltage change amount in a motor drive system, including a positive temperature change rate voltage generation module, a circuit bias module, and a temperature detection module that are integrated on a same substrate. An external power supply voltage is processed by the positive temperature change rate voltage generation module and the circuit bias module, and then inputted to the temperature detection module. The temperature detection module detects in real time the temperature change amount in the motor drive system, convert the temperature change amount into the voltage change amount, and transfer the voltage change amount to the circuit bias module, to allow the circuit bias module to output the voltage change amount. In this way, the conversion from the temperature change amount into the voltage change amount is realized.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: A method for coupling hydraulic fracture network extension and production performance of a horizontal well in an unconventional oil and gas reservoir includes: establishing a complex hydraulic fracture network model of a fractured horizontal well in an unconventional oil and gas reservoir based on a fracture extension theory; constructing three-dimensional three-phase mathematical models of seepage for the fractured horizontal well based on an embedded discrete fracture model; and constructing a fully implicit numerical calculation model by a finite difference method through three-dimensional orthogonal grids, and solving iteratively, thereby accurately predicting a production performance characteristic of the fractured horizontal well in the unconventional oil and gas reservoir.

Abstract: The present disclosure provides a start-up initialization circuit of motor drive system, including a power amplitude detecting and internal power supply module, a controlled delay module, a waveform shaping module and a power supply judging and adjusting module integrated on a same substrate, configured to detect and manage a voltage change of each node of a drive system in real time to cause a motor drive system to realize a start-up initialization process transit from an off state to a normal working state. The present disclosure finally forms the start-up initialization circuit of motor drive system by integrating the power amplitude detecting and internal power supply module, the controlled delay module, the waveform shaping module and the power supply judging and adjusting module and integrating on a single chip, which greatly ensures the reliability of power on and start-up of the motor drive system.

Abstract: Technologies relating to generation of training data for use in training a computer-implemented ranker are described. A product name extracted from a URL in a log entry of a search log of a search engine is mapped to a catalog product name from a catalog of a website, wherein the catalog product name identifies a product that is available for acquisition by way of a webpage of a website. A query assigned to the URL in the log entry is assigned to the catalog product name due to the product name being mapped to the catalog product name. The computer-implemented ranker is trained based upon the query being assigned to the catalog product name.

Abstract: Disclosed is a circuit for converting a temperature change amount into a voltage change amount in a motor drive system, including a positive temperature change rate voltage generation module, a circuit bias module, and a temperature detection module that are integrated on a same substrate. An external power supply voltage is processed by the positive temperature change rate voltage generation module and the circuit bias module, and then inputted to the temperature detection module. The temperature detection module detects in real time the temperature change amount in the motor drive system, convert the temperature change amount into the voltage change amount, and transfer the voltage change amount to the circuit bias module, to allow the circuit bias module to output the voltage change amount. In this way, the conversion from the temperature change amount into the voltage change amount is realized.

Abstract: The present disclosure provides a start-up initialization circuit of motor drive system, including a power amplitude detecting and internal power supply module, a controlled delay module, a waveform shaping module and a power supply judging and adjusting module integrated on a same substrate, configured to detect and manage a voltage change of each node of a drive system in real time to cause a motor drive system to realize a start-up initialization process transit from an off state to a normal working state. The present disclosure finally forms the start-up initialization circuit of motor drive system by integrating the power amplitude detecting and internal power supply module, the controlled delay module, the waveform shaping module and the power supply judging and adjusting module and integrating on a single chip, which greatly ensures the reliability of power on and start-up of the motor drive system.

Abstract: Disclosed is a circuit for shifting a fixed ground level to a floating ground level in a motor drive system, including a floating ground high level line, a floating ground output level line, a floating ground low level line, a normal input level line, and a normal ground line that are used for characterizing an application detail. The circuit includes a controlled switching current source, a first upper current rectifier, a second upper current rectifier, a lower current rectifier, and an amplifying and shaping circuit that are integrated on a same substrate.

Abstract: There are provided bivalent compounds and conjugates thereof, the conjugates comprising a bivalent compound, a targeting moiety, and a bioactive agent, as well as pharmaceutical compositions and methods of use of the conjugate for the treatment, inhibition, or prevention of diseases and disorders which are therapeutic targets of the bioactive agent.

Abstract: Common-mode transient immunity circuit and modulation-demodulation circuit, common-mode transient immunity circuit is applied to connecting with modulation circuit or demodulation circuit, comprising first isolation circuit, common-mode bias circuit, reference circuit and comparison circuit. Common-mode bias circuit provides common-mode bias voltage for first isolation circuit; first isolation circuit transmits common-mode bias voltage to comparison circuit; reference circuit provides reference voltage for comparison circuit; comparison circuit compares common-mode bias voltage with reference voltage, when common-mode bias voltage is larger than reference voltage, comparison circuit outputs enable signal to modulation circuit or demodulation circuit, and modulation circuit is driven to stop outputting modulation signal or demodulation circuit is driven to stop receiving modulation signal.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Embodiments of the present disclosure provide for methods of making quantum dots (QDs) (passivated or unpassivated) using a continuous flow process, systems for making QDs using a continuous flow process, and the like. In one or more embodiments, the QDs produced using embodiments of the present disclosure can be used in solar photovoltaic cells, bio-imaging, IR emitters, or LEDs.

Abstract: A method and apparatus for providing recommended contents. The method comprises: A search query being received; an event being selected from a predetermined event set based on the search query; the recommended contents being provided in a structured template including one or more elements; each element is associated with a feature of the event; each feature of the event corresponds to a search intent. Each element includes one or more sub-contents, and each sub-content is correlated to corresponding recommended contents.

Abstract: Common-mode transient immunity circuit and modulation-demodulation circuit, common-mode transient immunity circuit is applied to connecting with modulation circuit or demodulation circuit, comprising first isolation circuit, common-mode bias circuit, reference circuit and comparison circuit. Common-mode bias circuit provides common-mode bias voltage for first isolation circuit; first isolation circuit transmits common-mode bias voltage to comparison circuit; reference circuit provides reference voltage for comparison circuit; comparison circuit compares common-mode bias voltage with reference voltage, when common-mode bias voltage is larger than reference voltage, comparison circuit outputs enable signal to modulation circuit or demodulation circuit, and modulation circuit is driven to stop outputting modulation signal or demodulation circuit is driven to stop receiving modulation signal.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.