Patents by Inventor Jun R. Huh
Jun R. Huh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220072101Abstract: Described herein are methods and compositions related to a method of treating a neurodevelopmental disorder in a subject in need thereof, the method comprises administering to the subject an agent that increases the level or activity of interleukin-17a (IL-17a) in the brain. The method can further comprise administering an agent that increases the permeability of the blood brain barrier.Type: ApplicationFiled: January 9, 2020Publication date: March 10, 2022Applicants: President and Fellows of Haravrd College, Massachusetts Institute of TechnologyInventors: Jun R. HUH, Bohyun Gloria CHOI
-
Publication number: 20210347811Abstract: Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for promoting differentiation of T regulatory (Treg) lymphocytes, and for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, and graft-versus-host disease.Type: ApplicationFiled: October 8, 2019Publication date: November 11, 2021Inventors: Dan R. LITTMAN, Jun R. HUH, Michael FISCHBACH
-
Patent number: 10561666Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: GrantFiled: November 14, 2016Date of Patent: February 18, 2020Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, NEW YORK UNIVERSITYInventors: Dan Littman, Jun R. Huh, Ruili Huang, Wenwei Huang, Erika Elaine Englund
-
Publication number: 20190078143Abstract: Provided is a method for identifying and reducing the risk of a female subject producing an offspring having a neurodevelopmental disorder. The method comprises detecting in the subject the presence of gut bacteria that promote Th17 cell biogenesis. If such bacteria are detected, the individual can be administered a therapy that inhibits the growth or Th17 cell biogenesis promoting activity of the bacteria, and/or reduces the activity of the Th17 cells in the gut.Type: ApplicationFiled: September 11, 2018Publication date: March 14, 2019Inventors: Dan R. Littman, Jun R. Huh, Gloria B. Choi, Sangdoo Kim
-
Publication number: 20180371076Abstract: The present invention provides a method for reducing the risk of developing a psychiatric disorder (e.g., ASD, of which autism is a particular example) in a fetus comprising administering an inhibitor of T helper 17 (Th17) cell activity to the mother of the fetus, while the mother is pregnant with the fetus. The invention further relates to the use and application of compounds or agents that inhibit Th17 activity or that inhibit IL-17a or IL-17 signaling for reducing fetal risk for developing a psychiatric disorder. The invention relates to compounds or agents that inhibit Th17 activity or that inhibit IL-17a for reducing fetal risk for developing a psychiatric disorder, such as ASD, and use of such compounds or agents in the preparation of a medicament for reducing fetal risk for developing a psychiatric disorder.Type: ApplicationFiled: January 26, 2018Publication date: December 27, 2018Inventors: Dan R. Littman, Jun R. Huh
-
Patent number: 10100113Abstract: Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an inhibitor of T helper 17 (Th17) cell activity to the mother of the fetus, while the mother is pregnant with the fetus at risk. Also encompassed herein is a method for treating a fetus in utero to reduce the risk of abnormal cortical development that arises from Th17 cell-mediated activity.Type: GrantFiled: February 12, 2016Date of Patent: October 16, 2018Assignee: NEW YORK UNIVERSITYInventors: Dan R. Littman, Jun R. Huh
-
Publication number: 20170326356Abstract: Methods for treating subjects afflicted with a psychiatric disorders [e.g., autism spectrum disorder (ASD), schizophrenia, and/or depression] are described herein. More particularly, the present invention relates to a method for treating a subject afflicted with or at risk for developing a psychiatric disorder (e.g., ASD, of which autism is a particular example) that calls for selecting a subject afflicted with or at risk for developing the psychiatric disorder based in part on previous in utero exposure to maternal immune activation (MIA) and treating the subject by administering pharmacological agents or implementing optogenetic tools or chemogenetic tools that correct dysregulated neuronal excitation/inhibition (E/I) ratios in cortical patches of the subject wherein the E/I ratio is dysregulated. A subject may also be selected for treatment using methods described herein based on the presence or detection of cortical patches having dysregulated neuronal E/I ratios.Type: ApplicationFiled: January 26, 2017Publication date: November 16, 2017Inventors: Jun R. HUH, Bohyun Gloria CHOI, Dan R. LITTMAN, Yeong Shin YIM
-
Patent number: 9765063Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein Cy1, Cy2, n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: GrantFiled: September 10, 2012Date of Patent: September 19, 2017Assignees: New York University, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Dan Littman, Jun R. Huh, Ruili Huang, Wenwei Huang, Erika E. Englund
-
Publication number: 20170065606Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: ApplicationFiled: November 14, 2016Publication date: March 9, 2017Inventors: Dan LITTMAN, Jun R. HUH, Ruili HUANG, Wenwei HUANG, Erika Elaine ENGLUND
-
Patent number: 9505798Abstract: Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: GrantFiled: November 28, 2011Date of Patent: November 29, 2016Assignees: New York University, Memorial Sloan-Kettering Cancer CenterInventors: Dan R. Littman, Jun R. Huh, Nicolas Gabriel Albert Manel, Daniel A. Ryan, David Y. Gin, Mary S. Gin, Michael R. Krout
-
Patent number: 9492439Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: GrantFiled: March 11, 2011Date of Patent: November 15, 2016Assignees: New York University, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Dan Littman, Jun R. Huh, Wenwei Huang, Ruili Huang, Erika Elaine Englund
-
Publication number: 20160257743Abstract: Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an inhibitor of T helper 17 (Th17) cell activity to the mother of the fetus, while the mother is pregnant with the fetus at risk. Also encompassed herein is a method for treating a fetus in utero to reduce the risk of abnormal cortical development that arises from Th17 cell-mediated activity.Type: ApplicationFiled: February 12, 2016Publication date: September 8, 2016Inventors: Dan R. Littman, Jun R. Huh
-
Patent number: 9101600Abstract: Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as ROR?t modulators that have a formula represented by the following: and wherein n1, n2, R1, R2, R3, and R4 are as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: GrantFiled: March 11, 2011Date of Patent: August 11, 2015Assignees: New York University, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Dan Littman, Jun R. Huh, Wenwei Huang, Ruili Huang
-
Publication number: 20150057278Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein Cy1, Cy2, n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: ApplicationFiled: September 10, 2012Publication date: February 26, 2015Inventors: Dan Littman, Jun R. Huh, Ruili Huang, Wenwei Huang, Erika E. Englund
-
Publication number: 20140066391Abstract: Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: ApplicationFiled: November 28, 2011Publication date: March 6, 2014Inventors: Dan R. Littman, Jun R. Huh, Nicolas Gabriel Albert Manel, Michael R. Krout, Daniel A. Ryan
-
Publication number: 20130085162Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: ApplicationFiled: March 11, 2011Publication date: April 4, 2013Inventors: Dan Littman, Jun R. Huh, Wenwei Huang, Ruili Huang, Erika Elaine Englund
-
Publication number: 20130065842Abstract: Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as ROR?t modulators that have a formula represented by the following: and wherein n1, n2, R1, R2, R3, and R4 are as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.Type: ApplicationFiled: March 11, 2011Publication date: March 14, 2013Inventors: Dan Littman, Jun R. Huh, Wenwei Huang, Ruili Huang