Abstract: Systems, methods, and devices that perform flow scan sequences are provided. In one embodiment, an ultrasound imaging system includes an intraluminal catheter or guidewire, an annular array of acoustic elements positioned around a circumference of the catheter or guidewire, and a processor in communication with the annular array. The processor is configured to activate a first subaperture of the annular array at a first time, thereafter, activate a second interleaving subaperture, and activate the first subaperture again at a different, second time such that the scan sequence moves around the circumference of the catheter or guidewire. Temporal differences between the received ultrasound signals obtained by the first subaperture at the first and second times are determined to detect motion around the annular array. By interleaving subaperture firings, the total number of firings to form an image frame can be reduced.

Abstract: Systems and methods for suppressing off-axis sidelobes and/or clutter, near-field reverberation clutter, and/or grating lobe contributions are disclosed. A dual apodization with median (DAM) filtering technique is disclosed. The dual apodization technique may include summing aligned channel data with apodization functions (406, 412, 414) with complementary apertures applied. Median values for a zero function (RF3) and the resulting signals (RF1, RF2) from the complementary apertures are determined to generate a median value signal (416, MVS). The median value signal is used to generate an ultrasound image with enhanced image contrast. A method of image smoothing of the ultrasound image with enhanced image contrast is also disclosed. The smoothed image may include low frequency components of the ultrasound image with enhanced image contrast and high frequency components of an original image.

Abstract: Systems, methods, and devices for generating ultrasound images that have reduced or minimized grating lobe artifacts are provided. In one embodiment, an ultrasound imaging system includes an array of acoustic elements, and a processor in communication with the array. The processor is configured to receive electrical signals from the array, determine, based on the directivity of the acoustic elements, a portion of the electrical signals corresponding to on-axis components, generate a weighting mask based on the portion, and apply the weighting mask to an original image to generate a grating lobe minimized image. Because grating lobe artifacts are caused, in part, by reflections from off-axis objects, applying the weighting mask to an original image can reduce the presence of grating lobe artifacts in the original image.

Abstract: Aspects of the invention include ultrasound systems that suppress grating lobe artifacts arising due to high frequency operation of an array transducer probe which is operated at a frequency higher than its pitch limitation.

Abstract: The invention provides a method for controlling the generation of a compound ultrasonic image. The method includes obtaining a first ultrasound image and applying adaptive beamforming to the first ultrasound image, thereby generating a second ultrasound image. A weighting is determined based on the first and second ultrasound images, wherein the weighting comprises at least one weighting component. The compound ultrasound image is then generated based on the first and second ultrasound images and the weighting component.

Abstract: Ultrasound imaging system, devices, and methods for minimizing grating lobe artefacts in an ultrasound image are provided. For example, an ultrasound imaging system can include an array of acoustic elements and a processor in communication with the array. The processor controls the array to activate a plurality of apertures and subapertures in a scan sequence, generate an image comprising a plurality of pixels, identify at least one subaperture of the plurality of subapertures corresponding to a reduced signal value for one or more pixels of the image, and generate a grating-lobe-minimized image based on the identified subapertures. The grating-lobe-minimized image can be output to a display or combined with the original ultrasound image to include image features lost or reduced in the grating-lobe-minimized image. The grating-lobe-minimized image advantageously reduces image artefacts and clutter to simplify ultrasound image analysis and diagnosis procedures.

Abstract: A method in accordance with the present disclosure may include transmitting an ultrasound pulse toward a medium from a transducer array (305), detecting a plurality of echo signals (313a, 313c, 313e) responsive to the ultrasound pulse using one or more elements of the transducer array (305), generating an interpolated signal (313b, 313d) by interpolating a signal characteristic of at least two existing echo signals after temporally aligning the existing echo signals, and generating ultrasound image data based on one or more existing echo signals and the interpolated signal.

Abstract: The invention provides methods and systems for generating an ultrasound image. In a method, the generation of an ultrasound image comprises: obtaining channel data, the channel data defining a set of imaged points; for each imaged point: isolating the channel data; performing a spectral estimation on the isolated channel data; and selectively attenuating the spectral estimation channel data, thereby generating filtered channel data; and summing the filtered channel data, thereby forming a filtered ultrasound image. In some examples, the method comprises aperture extrapolation. The aperture extrapolation improves the lateral resolution of the ultrasound image. In other examples, the method comprises transmit extrapolation. The transmit extrapolation improves the contrast of the image. In addition, the transmit extrapolation improves the frame rate and reduces the motion artifacts in the ultrasound image. In further examples, the aperture and transmit extrapolations may be combined.

Abstract: An ultrasound system according to the present disclosure may include a beamformer configured to perform per-channel weighting on the RF signals received at each channel in order to reduce noise clutter in the image. For this purpose, the beamformer may receive at one or more channels associated with an active aperture, sets of receive signals associated with respective transmit beams that at least partially overlap. The beamformer may alter the receive space, e.g., to align the sets of receive signals to a common location (e.g., between the transmit beams) and generate a coherence-based weighting value that may be indicative of blockage. The coherence-based weighting value may be applied on a per-channel basis to the receive signals. The beamformer may also communicate the coherence metric to the controller for altering the transmit space.

Abstract: The invention provides a method for generating an ultrasound image. The method includes obtaining ultrasound data from an ultrasonic transducer array, the ultrasonic transducer array having M transducer elements. The method further includes generating N sets of image data from the ultrasound data using N random apodization functions. A minimizing function is then applied to a collection of image data, wherein the collection of image data comprises the N sets of image data. An ultrasound image is then generated based on the minimized image data.

Abstract: The invention provides methods and systems for generating an ultrasound image. In a method, the generation of an ultrasound image comprises: obtaining channel data, the channel data defining a set of imaged points; for each imaged point: isolating the channel data; performing a spatial spectral estimation on the isolated channel data; and selectively attenuating the spatial spectral estimation channel data, thereby generating filtered channel data; and summing the filtered channel data, thereby forming a filtered ultrasound image. In some examples, the method comprises aperture extrapolation. The aperture extrapolation improves the lateral resolution of the ultrasound image. In other examples, the method comprises transmit extrapolation. The transmit extrapolation improves the contrast of the image. In addition, the transmit extrapolation improves the frame rate and reduces the motion artifacts in the ultrasound image. In further examples, the aperture and transmit extrapolations may be combined.

Abstract: Improved ultrasound imaging devices and methods of operating the devices that minimize grating lobe artifacts in an ultrasound image are provided. For example, an ultrasound imaging system analyzes the ultrasound data at different frequency bands and generates a grating-lobe-minimized image based on minimum signals identified for each pixel among the plurality of frequency ranges. In one embodiment, an ultrasound imaging system includes an ultrasound transducer array configured to obtain ultrasound data, and a processor in communication with the ultrasound transducer array. The processor is configured to receive the ultrasound data, generate an ultrasound image based on a first frequency range of the ultrasound data, generate a grating-lobe-minimized ultrasound image based on a plurality of second frequency ranges of the ultrasound data, combine the ultrasound image and the grating-lobe-minimized ultrasound image to generate a combined ultrasound image, and output the combined ultrasound image to a display.

Abstract: Improved ultrasound imaging devices and methods of using the devices are provided. An intraluminal imaging device is configured process imaging data obtained using a single imaging sequence in different processing paths to generate B-mode and flow images. For example, an ultrasound imaging system includes an ultrasound imaging device comprising an array of acoustic elements and a processor in communication with the array. The processor activates the array of acoustic elements to acquire ultrasound data using a sequence of transmit-receive pairs, generates a B-mode image using the acquired ultrasound data, forms a plurality of sub-apertures comprising a portion of the transmit-receive pairs, groups the sub-apertures into temporally-spaced ensembles, determines a flow estimate based on a comparison of at least one of sub-apertures within an ensemble, ensembles within an aperture, or different apertures, and outputs a graphical representation of the B-mode image and the flow estimate to a display.

Abstract: An ultrasound imaging system (1) comprises an ultrasound transducer array (100) comprising a plurality of ultrasound transducer tiles (101a-d), each of said tiles having an independently adjustable orientation such as to conform an ultrasound transmitting surface to a region of a body (50) including a foreign object such as a pacemaker, a stent, or an interventional tool (200). Using a known spatial arrangement of a plurality of features (201-204) of the foreign object (200), the respective ultrasound images generated by the ultrasound transducer tiles are registered in order to generate a composite image, in which the position and orientation of the foreign object in the individual images is superimposed. The position and orientation of an interventional tool may be determined for each image using object recognition algorithms or using acoustic feedback information provided by at least three ultrasound sensors (201-204) arranged in a known spatial arrangement on the interventional tool.

Abstract: A method is provided for filtering ultrasound image clutter. In the first stage of the method a data matrix is captured, wherein the data matrix contains information relating to the image, and singular value decomposition (SVD) is performed on the data matrix or a matrix derived from the data matrix. A spatial singular vector is then obtained from the SVD of the data matrix and a mean spatial frequency is estimated from them. A filtered data matrix is constructed based on the estimated mean spatial frequency and the SVD of the data matrix and a filtered image is constructed based on the filtered data matrix.

Abstract: An ultrasound transducer array (100) is disclosed comprising an array of elongate support members (110) displaceable and/or deformable relative to each other in the elongation direction of said elongate support members, each elongate support member having a patient facing surface carrying an ultrasound transducer tile (120); and a plurality of sensors (115), each adapted to detect the relative displacement and/or deformation of one of said elongate support members. An ultrasound system (10) including such an ultrasound transducer array and an operating method (200) of such an ultrasound system are also disclosed.

Abstract: Provided is niacin-peptide which has skin whitening activity. The peptide of the present invention has skin whitening activity by inhibiting melanogenesis, that is, by inhibiting the expression of a gene related to melanogenesis (for example, TRP-1, TRP2, or MIFT). The peptide of the present invention has high stability and skin permeability. Also provided is a cosmetic composition for skin whitening which contains the niacin-peptide.

Abstract: Provided is niacin-peptide which has skin whitening activity. The peptide of the present invention has skin whitening activity by inhibiting melanogenesis, that is, by inhibiting the expression of a gene related to melanogenesis (for example, TRP-1, TRP2, or MIFT). The peptide of the present invention has high stability and skin permeability. Also provided is a cosmetic composition for skin whitening which contains the niacin-peptide.