Abstract: Provided is a 2-cyanopyrimidin-4-yl carbamate or urea derivative or pharmaceutically acceptable salt thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 2-cyanopyrimidin-4-yl carbamate or urea derivative or pharmaceutically acceptable salt thereof selectively inhibits cathepsin K and therefore can be usefully applied for preventing or treating osteoporosis.

Abstract: A method of manufacturing a membrane-electrode assembly includes: forming an electrolyte membrane containing an ionomer on a base material; applying an electrode slurry containing a catalyst, a binder, and a solvent to a first surface of the electrolyte membrane to form a structure including the electrolyte membrane and an electrode layer laminated on the first surface of the electrolyte membrane; and delaminating the structure from the base material.

Abstract: Provided are agents that specifically bind a ligand of ciliary neurotrophic factor receptor (CNTFR). In certain aspects, an agent of the present disclosure is a soluble CNTFR polypeptide. The soluble CNTFR polypeptide may have an altered (e.g., reduced) binding affinity for one or more ligand-CNTFR complex subunits, an altered (e.g., increased) binding affinity for one or more CNTFR ligands, or any combination thereof. Compositions that include the agents of the present disclosure are also provided, as are methods of using the agents (e.g., for treating a cell proliferative disorder) and methods of identifying an individual as having a cell proliferative disorder associated with CNTFR signaling.

Abstract: A fuel cell includes an electrolyte membrane-electrode assembly, a durability enhancing layer formed on at least one side of the electrolyte membrane-electrode assembly, and a gas diffusion layer formed on a side of the durability enhancing layer opposite a side on which the electrolyte membrane-electrode assembly is formed, wherein the durability enhancing layer includes a hydrogen peroxide decomposition catalyst and a hydrogen ion conductive polymer and is formed on at least a part of the at least one side of the electrolyte membrane-electrode assembly.

Abstract: Provided are ciliary neurotrophic factor receptor (CNTFR) ligands. In certain aspects, a CNTFR ligand of the present disclosure exhibits increased affinity for CNTFR relative to the corresponding wild-type CNTFR ligand. In certain aspects, a CNTFR ligand of the present disclosure results in reduced binding affinity of glycoprotein 130 (gp130), leukemia inhibitory factor receptor (LIFR), or both, for a complex including the CNTFR ligand and CNTFR, relative to the binding affinity for a complex including the corresponding wild-type CNTFR ligand and CNTFR. In certain aspects, a CNTFR ligand of the present disclosure has both of the aforementioned properties. Also provided are pharmaceutical compositions including the CNTFR ligands, as well as methods of using the CNTFR ligands.

Abstract: The wearable gravity compensation apparatus capable of multiple degrees of freedom of movement according to an example embodiment includes a main frame configured to be fixable to a back of a user, a base link rotatably connected to the main frame around a first rotation axis, a front extension link having one end rotatably connected to the base link around a second rotation axis intersecting the first rotation axis, the front extension link extending to a front of the base link, a rear extension link connected to the base link, the rear extension link extending to a rear of the base link, a guide positioned above the base link, the guide provided on the main frame, a slider configured to be slidable along the guide, a gravity compensation elastic member having one end fixed to the main frame, and the other end fixed to the slider.

Abstract: A display device includes a display panel, a folding information detector, a control module, and a distortion compensator. The display panel displays an image and includes a folding area folded with respect to an imaginary folding axis and a plurality of non-folding areas adjacent to the folding area when viewed in a plan view. The folding information detector detects folding information about the display panel, and a control module outputs a control signal based on the folding information provided from the folding information detector. The distortion compensator compensates for a distortion of the image displayed through the folding area in response to the control signal.

Abstract: Disclosed herein are an elastic encoder and manufacturing method thereof. The elastic encoder of the present invention includes a reinforcing rim which has a reinforcing body and a reinforcing flange formed along a peripheral part of the reinforcing body and which is manufactured using a metallic material; and a plastic magnet which is bound to the reinforcing flange so as to surround the reinforcing flange, includes synthetic resin, rubber material, and magnetic powder, and has a plurality of magnetic poles magnetized in a circumferential direction.

Abstract: A display device includes: a display panel including: a first area defined by an area corresponding to an opening in the display panel, the first area configured not to display an image; and a display area surrounding the first area and configured to display an image; and a first electronic module disposed in the opening of a lower part of the display panel overlapping the first area, wherein the display device is configured to display a first boundary image in a part of the display area adjacent to a boundary between the first area and the display area, and wherein the display device is configured to provide predetermined information to a user through a combination of the first area and the first boundary image.

Abstract: The present disclosure relates to a preparation method of a methionine-metal chelate, and the methionine-metal chelate, which is prepared by first reacting Ca(OH)2 and methionine and adding metal chloride salts, can be used as feeds and feed additives.

Abstract: A display module includes a window including a base substrate and a bezel pattern overlapping the base substrate in a plan view, and a display panel. The bezel pattern includes a first bezel pattern extending along an edge of the base substrate, and a second bezel pattern which extends from the first bezel pattern and of which at least a portion defines a transmission area. The display panel includes a glass substrate, an encapsulation substrate on the glass substrate, a sealing member coupling the glass substrate and the encapsulation substrate and overlapping the first bezel pattern in the plan view, a circuit element layer disposed on the glass substrate and including a transistor, and a display element layer disposed on the circuit element layer and including light emitting elements. The display element layer exposes a portion of a layer disposed thereunder, which corresponds to the transmission area.

Abstract: A display device includes: a display panel including: a functional area defined by an opening formed in the display panel; and a display area defined as an area where a plurality of light emitting elements are arranged, surrounding the functional area; and a functional module including a lens disposed overlapping the functional area, wherein only some of the plurality of light emitting elements of the display panel are configured to emit light in a low power mode, and wherein all of the plurality of light emitting elements are configured to emit light in a general mode; and wherein the display device is configured to, in the low power mode, provide a predetermined information to a user formed by the boundary between the functional area and the display area and an image formed by light emission of the some of the plurality of light emitting elements.

Abstract: Disclosed are an electrode for fuel cells, a membrane electrode assembly for fuel cells including the same and a method for manufacturing the same in which the electrode is manufactured by forming an ionomer layer between an electrode layer and a catalyst layer and an antioxidant is dispersed into the catalyst layer of the electrode and an ion exchange layer of an electrolyte membrane so as to improve interfacial bonding force between the electrode and the electrolyte membrane, the electrode is bonded to the electrolyte membrane using a transfer process, and durability of the electrode and the electrolyte membrane is improved.