Abstract: The present invention relates to a compound capable of lowering the flammability of a non-aqueous electrolyte when included in the non-aqueous electrolyte and improving the life properties of a battery by forming an electrode-electrolyte interface which is stable at high temperatures and low in resistance, and relates to a compound represented by Formula I descried herein, a non-aqueous electrolyte solution and a lithium secondary battery both including the compound, n, m, Ak, and X are described herein.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: A lithium secondary battery includes a negative electrode, a positive electrode positioned opposite to the negative electrode, a separator disposed between the negative electrode and the positive electrode, and a non-aqueous electrolyte, wherein the negative electrode includes a silicon-based active material, the silicon-based active material comprises a compound represented by SiOx, wherein 0?x<2, the non-aqueous electrolyte includes a lithium salt, an organic solvent, and an additive, the additive includes a first additive and a second additive, the first additive includes a coumarin-based compound represented by Formula 1, and the second additive includes at least one of lithium fluoromalonato(difluoro)borate (LiFMDFB), lithium difluoro(oxalato)borate (LiDFOB), lithium difluorophosphate (LiDFP), or lithium difluorobis-(oxalate)phosphate (LiDFOP): wherein R and n are described herein.

Abstract: The present disclosure relates to a composition for skin improvement and a pharmaceutical composition for preventing or treating an inflammatory skin disease, the compositions including an umbilical cord-derived mesenchymal stem cell culture medium as an active ingredient. The compositions exhibit a wound relief, wrinkle improvement, regeneration, elasticity increase, moisturizing, barrier strengthening, anti-inflammatory or antioxidant effect, and thus can be effectively used as a cosmetic composition for skin improvement or a pharmaceutical composition for preventing or treating an inflammatory skin disease.

Abstract: A display device includes a substrate, a first electrode and a second electrode which are spaced apart from each other in a second direction, light-emitting elements spaced apart from each other in the first direction, a first contact electrode electrically contacting the light-emitting elements, and a second contact electrode electrically contacting the light-emitting elements. The first contact electrode electrically contacts the first electrode through a first contact portion disposed on the first electrode, the second contact electrode electrically contacts the second electrode through a second contact portion disposed on the second electrode, the first contact portion is disposed on an end portion in the first direction of the first contact electrode, and the second contact portion is disposed on an end portion in the first direction of the second contact electrode.

Abstract: A display apparatus including a light-emitting device and a method of forming the same are provided. The light-emitting device may be electrically connected to the driving circuit. A first planarization layer may be disposed on the driving circuit, a second planarization layer may be disposed on the first planarization layer, and the light-emitting device may be disposed on the second planarization layer. An upper surface of the second planarization layer toward the light-emitting device may be parallel with a surface of a device substrate supporting the light-emitting device and the driving circuit. Thus, in the display apparatus and the method of forming the same, decreasing the quality of an image due to differences in the generation position of the light emitted from the light-emitting device may be prevented.

Abstract: The present invention relates to a lung cancer model based on a normal lung organoid, prepared by fusing cancer cells to the normal lung organoid. By using the lung cancer model according to the present invention, it is possible not only to observe the progression or metastasis pattern of lung cancer from the early stage of proliferating lung cancer cells to the stage of forming a tumor but also to compare the effect of an anticancer agent at each stage, and thus the information on an appropriate therapeutic agent may be provided according to the stage of cancer development. In addition, since the lung cancer model according to the present invention includes a normal lung organoid and cancer cells, which are fused, it can be effectively used to confirm the effect of an anticancer agent on normal tissue and the effect of cancer cell-specific apoptosis.

Abstract: The present disclosure relates to an electrode rolling apparatus including a non-coating portion pressing unit that rolls a non-coating portion of an electrode substrate and an electrode rolling method using the same, and can prevent a swell from occurring in the non-coating portion region during the process of rolling the electrode substrate and increase the efficiency of the manufacturing process.

Abstract: A magnetic element according to an embodiment of the present invention a first core, a second core, a bobbin including a through-hole, the bobbin being at least partially disposed between the first core and the second core, a first coil unit and a second coil unit at least partially disposed on the bobbin, wherein at least one of the first coil unit or the second coil unit includes a plurality of conductive wires disposed around the through-hole, wherein the bobbin includes a first portion formed to allow the first end portion and the second end portion of each of the plurality of conductive wires to be disposed thereon and a second portion formed opposite the first portion in a horizontal direction, with the through-hole interposed therebetween, and wherein portions of the plurality of conductive wires overlap each other vertically on the second portion.

Abstract: A pharmaceutical composition for preventing or treating cancer, which is associated with a KRAS mutation and exhibits resistance to an EGFR-targeted therapeutic agent is disclosed. The pharmaceutical composition can be useful for treatment of patients with cancer which has the KRAS mutation and exhibits resistance to cetuximab that is an anticancer therapeutic agent. A method for providing information on an anticancer treatment and/or enhancing cancer treatment by identifying a KRAS mutation and optionally additionally a RON mutation are disclosed.

Abstract: A transformer according to one embodiment of the present invention comprises: a core unit including an upper core and a lower core; a coil unit of which a portion is disposed in the core unit; and a bobbin unit disposed between the core unit and the coil unit, wherein the coil unit includes a first coil and a second coil of which at least a portion is disposed on the side surface of the first coil, the core unit includes a first outer foot part, a second outer foot part, and an intermediate foot part disposed between the first outer foot part and the second outer foot part, and the shortest distance between the first coil and the second coil can be 0.1 to 0.3 times the shortest distance between the outermost part of the first coil and an adjacent outer foot part from among the first outer foot part and the second outer foot part.

Abstract: The present invention relates to a pharmaceutical composition comprising an agent inhibiting gene expression or protein activity of osteopontin as an active ingredient for preventing or treating neurodegenerative disease. According to the present invention, there is an effect of suppressing amyloid beta (A?)-induced neuronal cell death by downregulating the expression or activity of osteopontin. In addition, an inhibitor against the expression or activity of osteopontin decreases a level of pro-inflammatory proteins and conversely, increases a level of anti-inflammatory proteins. Therefore, it is expected that the present invention can be advantageously used as a therapeutic agent for various neurodegenerative diseases including Alzheimer's disease.

Abstract: A display apparatus including color filters is disclosed. The display apparatus may comprise a device substrate including pixel areas. A light-emitting device may be disposed on each pixel area. An encapsulating layer covering the light-emitting devices may be disposed on the device substrate. The color filters may be disposed on the encapsulating layer. For example, separating dams defining openings overlapping with the light-emitting devices may be disposed on the encapsulating layer. The pixel areas disposed in a first direction may display the same color. Some of the separating dams extending in a second direction that is different from the first direction between the pixel areas may have a relatively short length. Thus, in the display apparatus, the volume difference between the color filters may be reduced.

Abstract: A touch display device includes light emitting devices disposed on a substrate, an encapsulation unit disposed on the light emitting devices, a touch buffer film disposed on the encapsulation unit, second bridge electrodes disposed on the touch buffer film, a black matrix disposed on the touch buffer film and including openings, color filters that fill the openings, and a cover layer disposed on the color filters and the black matrix.

Abstract: A blockchain based data management method performed by a computing device according to an embodiment of the present disclosure includes recording a deletion event for off-chain data and time information of the deletion event in a blockchain network, and selectively deleting the off-chain data based on a validity verification result calculated for the time information, wherein the validity verification result is calculated using a time-consensus algorithm of the blockchain network.

Abstract: An electrode manufacturing device is provided. The electrode manufacturing device includes a pressing roll configured to apply pressure to an uncoated part of the electrode, wherein the pressing roll comprises a central part, a first end part and a second end part, wherein the uncoated part comprises an insulating coated part and a non-insulating coated part, wherein the first end part is adjacent to a boundary between the insulating coated part and the non-insulating coated part, wherein the second end part is located at a portion far away from the insulating coated part, and wherein a first outer diameter of the central part connected to the first end part is greater than a second outer diameter of the central part connected to the second end part.

Abstract: A blockchain-based data distribution management method according to an embodiment is performed by a computing device. The method includes generating a plurality of shards by fragmenting a first information, requesting a first block event for distributed storage of the plurality of shards in a plurality of off-chain storages to a blockchain network, and transmitting the plurality of shards to the plurality of off-chain storages, wherein a second information indicating a history of the plurality of shards distributed and stored in the plurality of off-chain storages is recorded in the blockchain network through the first block event, wherein when a predetermined number or more of shards among the plurality of shards are collected, the first information is restored from the collected predetermined number or more of shards.

Abstract: A blockchain data recording method includes determining a recording type as one of an on-chain type and an off-chain type according to a target data to be recorded in a blockchain, transmitting a first transaction proposal for recording the target data in a blockchain node configured to store an on-chain data on a blockchain to the blockchain node when the recording type is an on-chain type, and recording the target data in a storage node provided to store an off-chain data, and transmitting a second transaction proposal for storing recording information of the target data in the blockchain to the blockchain node when the recording type is an off-chain type.

Abstract: A web scanning attack detection device includes a web log collector collecting web logs generated for a preset time with respect to each of at least one client connected to a web site, a field value extractor extracting field values for a target field from the web logs, a classifier calculating an appearance frequency of each of the field values in the web logs and classify each of the field values as one of a normal group and a candidate group based on the appearance frequency, and a detector calculating a similarity between each field value classified as the normal group and each field value classified as the candidate group, detects an anomaly field value among each field value classified as the candidate group based on the similarity, and detecting an anomaly web log including the anomaly field value among the web logs.

Abstract: A permanent magnet of an embodiment comprises: a base magnet represented by a-b-c (a includes a rare earth-based element, b includes a transition element, and c includes boron (B)); and a coating layer coated on a surface of the base magnet, wherein the coating layer comprises a compound containing a metal having magnetism, the compound including: a phosphor (P); and a metal belonging to the fourth period in the periodic table.