Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

Abstract: The present invention pertains to a novel lappaconitine derivative, a method for producing same, and a pharmaceutical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into osteoblasts, increases bone mineral density when administered to animal models of osteoporosis, and induces bone formation in animal models of bone fracture, and thus can be advantageously used for preventing, ameliorating, or treating bone-related diseases such as osteoporosis, as well as treating non-disease fractures caused by physical trauma.

Abstract: The present invention includes obtaining block type identification information on a partition of the current macroblock when the current macroblock is intra-mixed specifying a bock type of the current macroblock based on the block type identification information, obtaining an intra prediction mode of the current macroblock according to the block type of the partition of the current macroblock, and predicting the current macroblock using the intra prediction mode and a pixel value of a neighboring block.

Abstract: A lithium secondary battery includes a cathode, a separator, and an anode including an anode current collector and an anode active material layer formed on the anode current collector and facing the cathode with the separator interposed therebetween. The anode active material layer includes a first anode active material layer formed on the anode current collector and including a first anode active material and a first anode binder containing a styrene-butadiene-based rubber (SBR) binder and a second anode active material layer formed on the first anode active material layer and including a second anode active material and a second anode binder containing a acryl-based binder. Each of the first anode active material and the second anode active material includes a silicon-based active material and a graphite-based material and contains 2 to 9.5 parts by weight of silicon with respect to the 100 part by weight of the graphite-based active material.

Abstract: A multilayer ceramic capacitor includes: a ceramic body in which dielectric layers and first and second internal electrodes are alternately stacked; and first and second external electrodes formed on an outer surface of the ceramic body and electrically connected to the first and second internal electrodes, respectively. In a microstructure of the dielectric layer, dielectric grains are divided by a dielectric grain size into sections each having an interval of 50 nm, respectively, a fraction of the dielectric grains in each of the sections within a range of 50 nm to 450 nm is within a range of 0.025 to 0.20, and a thickness of the dielectric layer is 0.8 ?m or less.

Abstract: A polythiol composition according to exemplary embodiments includes: a polythiol-based compound; and a benzyl halide-based reaction regulator in an amount of 10 ppm to 2,000 ppm based on a weight of the polythiol-based compound. The reaction rate of the polythiol-based compound and an isocyanate-based compound may be controlled through the reaction regulator to inhibit a generation of stria phenomenon.

Abstract: The present disclosure relates to a vehicle rear seat including: a center seat; and side seats located on the left and right of the center seat, wherein, the center seat is capable of protruding by moving the center seat forward with respect to the side seats, and in the state in which the center seat protrudes forward, it is possible to increase an inter-passenger distance so that physical contact between the passenger of the center seat and the passenger of each of the side seats can be prevented as much as possible.

Abstract: Provided are an apparatus and method for generating a depth map by using a volumetric feature. The method may generate a single feature map for a base image included in a surround-view image by performing encoding and postprocessing on the base image, and generate a volumetric feature by encoding the single feature map with depth information and then projecting a result of the encoding into a three-dimensional space. In this method, a depth map of a surround-view image may be generated by using a depth decoder to decode a volumetric feature.

Abstract: Provided are a data processing method and apparatus for training a depth information estimation model. The data processing method for training a depth information estimation model, includes: logging image data collected from one or more cameras; transmitting the logged image data to a database; configuring training data, based on the image data of the database; and training a model, based on the training data.

Abstract: Disclosed herein are an apparatus for estimating a camera pose using multi-view images of a 2D array structure and a method using the same. The method performed by the apparatus includes acquiring multi-view images from a 2D array camera system, forming a 2D image link structure corresponding to the multi-view images in consideration of the geometric structure of the camera system, estimating an initial camera pose based on an adjacent image extracted from the 2D image link structure and a pair of corresponding feature points, and estimating a final camera pose by reconstructing a 3D structure based on the initial camera pose and performing correction so as to minimize a reprojection error of the reconstructed 3D structure.

Abstract: The present invention relates to a method for evaluating metabolic activity based on the concentrations of cortisol and its precursors and metabolites thereof in saliva collected by a swab for the measurement of adrenal steroids relating to biochemical stress evaluation and more particularly, to a method of comparing metabolic activity of physiologically different adrenal steroids by analyzing adrenal steroids including cortisol and cortisone extracted from a trace amount of saliva by mass spectrometry and evaluating the metabolic ratio between the two compounds as well as the absolute amount of each compound. Accordingly, the present invention can be utilized as an index for evaluating response to biochemical stress and related diseases by measuring the amounts of adrenal steroids including cortisol and cortisone in a trace amount of saliva collected with a swab.

Abstract: Provided is a node location tracking method, including an initial localization step of estimating initial locations of a robot and neighboring nodes using inter-node measurement and a Sum of Gaussian (SoG) filter, wherein the initial localization step includes an iterative multilateration step of initializing the locations of the nodes; and a SoG filter generation step of generating the SoG filter.

Abstract: Disclosed herein is a method for rectifying a 2D multi-view image. The method for rectifying a 2D multi-view image according to an embodiment of the present disclosure may include: detecting uniformly the at least one feature point in each region unit distinguished by considering a distribution of feature points of a plurality of input images: removing an error of the least one feature point; determining a corresponding pair for a vertical or horizontal direction of the at least one feature point; by considering an arrangement relationship of the plurality of input images, projecting the at least one feature point onto a projection plane; determining a disparity error for a corresponding pair for the at least one feature point that is projected onto the projection plane; and, by considering the disparity error, performing image rectification based on the at least one feature point.

Abstract: The present disclosure provides an RSS (Received Signal Strength) signal correction method for performing location measurement by utilizing information among a plurality of nodes, and the RSS signal correction method estimates a variable of an RSS signal model based on at least one of location information of a fixed node, location information of an unknown node and measurement noise information of the unknown node.

Abstract: Provided is a node location tracking method, including an initial localization step of estimating initial locations of a robot and neighboring nodes using inter-node measurement and a Sum of Gaussian (SoG) filter, wherein the initial localization step includes an iterative multilateration step of initializing the locations of the nodes; and a SoG filter generation step of generating the SoG filter.

Abstract: The present disclosure provides an RSS (Received Signal Strength) signal correction method for performing location measurement by utilizing information among a plurality of nodes, and the RSS signal correction method estimates a variable of an RSS signal model based on at least one of location information of a fixed node, location information of an unknown node and measurement noise information of the unknown node.

Abstract: The present invention relates to a pharmaceutical composition for treating diabetes, which includes a pancreatic islet cell and an elastin-like artificial extracellular matrix (REP), and more particularly, to a pharmaceutical composition for treating diabetes, in which pancreatic islet cells are reacted with an elastin-like artificial extracellular matrix and then the resulting cells are administered along with the elastin-like artificial extracellular matrix, thus increasing a survival rate of the transplanted pancreatic islet cells, rapidly restoring a blood glucose level to normal, and maintaining the restored blood glucose level for a long period of time, and, accordingly, diabetes may be more effectively treated.

Abstract: The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-?, or MIP-2.

Abstract: The present invention relates to a method for evaluating metabolic activity based on the concentrations of cortisol and its precursors and metabolites thereof in saliva collected by a swab for the measurement of adrenal steroids relating to biochemical stress evaluation and more particularly, to a method of comparing metabolic activity of physiologically different adrenal steroids by analyzing adrenal steroids including cortisol and cortisone extracted from a trace amount of saliva by mass spectrometry and evaluating the metabolic ratio between the two compounds as well as the absolute amount of each compound. Accordingly, the present invention can be utilized as an index for evaluating response to biochemical stress and related diseases by measuring the amounts of adrenal steroids including cortisol and cortisone in a trace amount of saliva collected with a swab.