Abstract: The present invention relates to verifying the suitability of a tool and diagnosing a spindle for a machining center on which different tools are mounted. Provided are a machining center spindle diagnosis apparatus and method configured to monitor a change of a tool in the machining center; when the change of the tool is recognized, control the machining center to idle the spindle; acquire sensor data from a sensor installed on the machining center during the idling of the spindle; input the acquired sensor data to a tool verifying model pre-trained by a machine learning technology to verify suitability of the tool; and when the tool is verified to be suitable, inputting the acquired sensor data to a spindle diagnosing model pre-trained by the machine learning technology to diagnose an operating state of the spindle.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.