Abstract: Described herein are compounds, pharmaceutical compositions, and methods for use in reversing cancer chemoresistance.

Abstract: A fuel tank has a primary sump and secondary sump. A first vent valve and a second vent valve are disposed within the fuel tank. The first vent valve is closed when a level of fuel in the primary sump is equal to or higher than a first predetermined filling level, and the second vent valve is closed when a level of fuel in the secondary sump is equal to or higher than a second predetermined filling level in a refueling procedure.

Abstract: A fuel tank has a primary sump and secondary sump. A first vent valve and a second vent valve are disposed within the fuel tank. The first vent valve is closed when a level of fuel in the primary sump is equal to or higher than a first predetermined filling level, and the second vent valve is closed when a level of fuel in the secondary sump is equal to or higher than a second predetermined filling level in a refueling procedure.

Abstract: The invention provides compositions and kits containing an atrogin-1 inhibitor compound useful for the treatment of a statin-mediated myopathy. Kits for the diagnosis of a statin-mediated myopathy are also provided. The invention further features methods for treating or preventing a statin-mediated myopathy in a subject via administration of a therapeutically effective amount of an atrogin-1 inhibitor compound. The invention further provides methods of diagnosing a subject as having a propensity to develop a statin-induced myopathy and methods of monitoring a statin-induced myopathy or a propensity to develop a statin-mediated myopathy in a subject. The invention also features methods for identifying a compound for the treatment of a statin-mediated myopathy and methods of identifying a statin compound as having the propensity to induce a statin-mediated myopathy.

Abstract: The invention features methods and compositions for treating and preventing cancer metastasis, angiogenic disorders, and fibrotic disorders using lipocalin 2 compounds.

Abstract: A fuel tank has a primary sump and secondary sump. A first vent valve and a second vent valve are disposed within the fuel tank. The first vent valve is closed when a level of fuel in the primary sump is equal to or higher than a first predetermined filling level, and the second vent valve is closed when a level of fuel in the secondary sump is equal to or higher than a second predetermined filling level in a refueling procedure.

Abstract: An inner diameter of a filler tube is formed smaller than that of a filler neck of a tank main body. Hence, a clearance is thus difficult to be created between inner peripheral surface of the filler tube and the fuel stream which flows through the filler tube upon supply of fuel, and also leakage of vapor fuel from a fuel filler port can be avoided. In addition, a cylindrical insert whose inner diameter is formed to be substantially equal to its of the filler tube is provided in a neck portion of the filler hose. Accordingly, there exists no portion where the inner diameter is largely changed in the filler neck portion, whereby generation of turbulent flow of the supplied fuel and reduction in a flow rate can be suppressed to their maximum and thus fuel supply performance can be enhanced.

Abstract: A canister structure for absorbing fuel vapor in the fuel tank and supplying the fuel vapor into the engine together with purge air is provided. The canister structure includes a canister body filled up with absorbents for absorbing the fuel vapor, a purge pipe connected to the canister body for introducing the purge air into the canister body and a separator for removing moisture contained in the purge air. To the separator, the purge pipe is connected downwardly. The separator is provided on the bottom side with an air inlet of which diameter is larger than that of the purge pipe. With the above-mentioned arrangement, since the separator is so formed as to have a diameter larger than that of the purge pipe, it is possible to reduce a flowing speed of the purge air by means of the separator, so that moisture contained in the purge air can be trapped and eliminated by the separator certainly.

Abstract: The fuel tank system comprises a tank body for containing fuel therein, a canister for disposing said fuel component, a filler tube connected with the tank body and forming a channel for supplying fuel to the tank body, a vent side check valve having a first chamber and a second chamber separated by a diaphragm, a signal tube connecting the first chamber of the vent side check valve with the upper part of the filler tube, a vent side tube for connecting the tank body with the canister via the second chamber of the vent side check valve and for introducing a gaseous body containing fuel component in the tank body to the canister via the second chamber when filling fuel, and an orifice for the signal tube, provided on the upper part of the signal tube on the filler tube side and having such an inside diameter and a length that may prevent the fuel permeation into the signal tube side from the filler tube side.

Abstract: A fuel control system includes a valve assembly disposed between a fuel tank with a filler tube and a fuel vapor storage canister. The valve assembly includes a housing having a vapor inlet port for establishing communication with the fuel tank at a level above the full level of fuel contained in the fuel tank, and a vent inlet port for establishing communication with the fuel tank until the full level is reached by fuel contained in the fuel tank. An outlet port is provided for establishing communication with the canister. A conduit is provided for transmiting signal pressure for establishing communication with the filler tube at a level above the fuel level of fuel in the filler tube. First and second check valves are mounted within the housing and respectively include valve seats, valve elements, springs and diaphragms. The diaphragms cooperate with the housing to define a signal pressure chamber communicating with the conduit.