Abstract: Echo-canceling apparatus of the invention includes transfer function estimation unit which estimates a transfer function corresponding to the reverberation of a room attached to a voice after it is output from a loudspeaker and before it is input to a microphone, a first filter unit which operates using the transfer function, a first subtraction unit which subtracts the output signal of the first filter unit from the signal from the microphone, a second filter unit which operates using the transfer function copied from the first filter unit in case the estimation accuracy of the transfer function estimation unit is high, a second subtraction unit which subtracts the output signal of the second filter unit from the signal from the microphone, a singing detection unit which detects singing, a notch filter unit which notches a specific frequency band component in the signal received from a far-end speaker, and a switch unit which selects between the signal from the far-end speaker processed by the notch filter u

Abstract: A novel human tumor suppressor gene coding for a tumor suppressor protein and whose expression is inhibited by human growth hormone. The DNA composing the gene, and the protein coded by the gene are also provided. The DNA has a nucleotide sequence set forth under SEQ ID NO:1 or SEQ ID NO:2 in the Sequence Listing.

Abstract: LEM which is an aqueous extract of a mycelial culture of Lentinus Edodes and has a sugar composition composed of arabinose, xylose, glucose, mannose, galasctose, fucose and rhamnose, as well as a fraction of LEM which corresponds to molecular weights of 10,000 to 1,000,000 daltons and has a sugar composition composed of arabinose, xylose, glucose, mannose and galactose are provided as agents for inhibiting the adsorption of herpesviruses such as herpes simplex to the cells.

Abstract: An inhibitor of the proliferation of herpesviruses and of the recurrence of affections caused by their latent infection, which is an active material obtained by fractional purification of the aqueous extract from cultured Lentinus edodes mycelia.

Abstract: Antiserum which can recognize all subtypes of human leukocyte interferon is prepared from the blood of an animal immunized with partially purified human leukocyte interferon obtained from a culture of human leukocyte stimulated with Sendai virus.The antiserum is added to a column whereon concentrated culture broth of human leukocyte has been immobilized to adsorb impurities, the effluent is added to a column whereon partially purified human leukocyte interferon has been immobilized to adsorb anti-human leukocyte interferon antibody and then the antibody is eluted from the column.The antibody thus obtained recognizes all subtypes of human leukocyte interferon and can be separated by a chromatography to each monoclonal antibody which recognizes a single subtype.Employing these antibodies, the subtypes of human leukocyte interferon or their antibodies in a sample can be analized or assayed.