Patents by Inventor Junichiro Uda
Junichiro Uda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10752601Abstract: A type II crystal of 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole, having characteristic peaks at least around 15.1, 18.1, 22.8, 23.7, and 24.0 degrees in a diffraction angle (2?) by X-ray powder diffraction, and method for producing said type II crystal.Type: GrantFiled: April 27, 2018Date of Patent: August 25, 2020Assignee: Fuji Yakuhin Co., LtdInventors: Junichiro Uda, Seiichi Kobashi, Misa Hasegawa
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Publication number: 20190389818Abstract: A type II crystal of 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole, having characteristic peaks at least around 15.1, 18.1, 22.8, 23.7, and 24.0 degrees in a diffraction angle (2?) by X-ray powder diffraction, and method for producing said type II crystal.Type: ApplicationFiled: April 27, 2018Publication date: December 26, 2019Inventors: Junichiro UDA, Seiichi KOBASHI, Misa HASEGAWA
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Patent number: 9428488Abstract: To provide an industrially useful method for producing pharmaceutically useful 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and an intermediate for producing the compound. The method for producing compound represented by formula (1) is represented by the following reaction scheme, and the intermediate is represented by the following formula (4).Type: GrantFiled: July 24, 2013Date of Patent: August 30, 2016Assignee: FUJIYAKUHIN CO., LTD.Inventors: Yoshiyuki Iwabuchi, Sachiho Miyata, Junichiro Uda, Osamu Nagata
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Patent number: 9199970Abstract: To provide crystal polymorphs of 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, which is a useful pharmaceutical, and a production method therefor. Through purification of a corresponding salt, recrystallization, or storage under humidified conditions, three different crystal forms; i.e., crystalline polymorphs of 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile are produced.Type: GrantFiled: July 24, 2013Date of Patent: December 1, 2015Assignee: FUJIYAKUHIN CO., LTD.Inventors: Yoshiyuki Iwabuchi, Sachiho Miyata, Takahiro Sato, Junichiro Uda, Takamitsu Kandou, Tadashi Inoue, Hiroyuki Nakano
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Publication number: 20150166510Abstract: To provide an industrially useful method for producing pharmaceutically useful 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and an intermediate for producing the compound. The method for producing compound represented by formula (1) is represented by the following reaction scheme, and the intermediate is represented by the following formula (4).Type: ApplicationFiled: July 24, 2013Publication date: June 18, 2015Applicant: FUJIYAKUHIN CO., LTD.Inventors: Yoshiyuki Iwabuchi, Sachiho Miyata, Junichiro Uda, Osamu Nagata
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Publication number: 20150126558Abstract: To provide crystal polymorphs of 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, which is a useful pharmaceutical, and a production method therefor. Through purification of a corresponding salt, recrystallization, or storage under humidified conditions, three different crystal forms; i.e., crystalline polymorphs of 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile are produced.Type: ApplicationFiled: July 24, 2013Publication date: May 7, 2015Applicant: FUJIYAKUHIN CO., LTD.Inventors: Yoshiyuki Iwabuchi, Sachiho Miyata, Takahiro Sato, Junichiro Uda, Takamitsu Kandou, Tadashi Inoue, Hiroyuki Nakano
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Patent number: 8367843Abstract: Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, R1 and R2 may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; R3 represents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an —S(?O)— group or an —S(?O)2— group.Type: GrantFiled: September 29, 2010Date of Patent: February 5, 2013Assignee: Fuji Yakuhin Co., Ltd.Inventors: Seiichi Kobashi, Junichiro Uda, Sachiho Miyata, Tsutomu Inoue, Naoki Ashizawa, Koji Matsumoto, Tetsuya Taniguchi, Takashi Iwanaga, Osamu Nagata
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Publication number: 20120184587Abstract: Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, R1 and R2 may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; R3 represents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an —S(?O)— group or an —S(?O)2— group.Type: ApplicationFiled: September 29, 2010Publication date: July 19, 2012Inventors: Seiichi Kobashi, Junichiro Uda, Sachiho Miyata, Tsutomu Inoue, Naoki Ashizawa, Koji Matsumoto, Tetsuya Taniguchi, Takashi Iwanaga, Osamu Nagata
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Patent number: 8148421Abstract: A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing actionType: GrantFiled: September 10, 2007Date of Patent: April 3, 2012Assignee: Fuji Yakuhin Co., Ltd.Inventors: Hideo Kato, Osamu Nagata, Yoshiyuki Iwabuchi, Takahiro Sato, Junichiro Uda, Tutomu Inoue, Hiroshi Nakamura, Nobuhide Kawasaki, Ippei Tanaka, Naoki Kurita, Tomohiko Ishikawa
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Publication number: 20100048666Abstract: A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing actionType: ApplicationFiled: September 10, 2007Publication date: February 25, 2010Applicant: FUJI YAKUHIN CO., LTD.Inventors: Hideo Kato, Osamu Nagata, Yoshiyuki Iwabuchi, Takahiro Sato, Junichiro Uda, Tutomu Inoue, Hiroshi Nakamura, Nobuhide Kawasaki, Ippei Tanaka, Naoki Kurita, Tomohiko Ishikawa
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Publication number: 20060217556Abstract: Provided are a process for producing an acid addition salt of a 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid alkyl ester by reacting a 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid alkyl ester with an acid, and a process for producing 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid using the acid addition salt as an intermediate.Type: ApplicationFiled: April 14, 2004Publication date: September 28, 2006Applicant: FUJIYAKUHIN CO., LTD.Inventors: Junichiro Uda, Tomomitsu Sasaki, Takahiro Sato, Tsutomu Inoue
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Publication number: 20060189811Abstract: Provided is a process for producing 1,2,4-triazole compound (5), or a salt or hydrate thereof which comprises reacting compound (1) with Rc-X (2) to give compound (3), reacting compound (3) with a nitrilization agent to give compound (4), and then removing the group Rc, as shown by the reaction scheme: (Wherein Ra, Rb and Rd represent a group, Rc represents a group which can be removed by an acid) A 1,2,4-triazole compound (5) having an optionally substituted 2-cyanopyridin-4-yl group at 3-position and an optionally substituted aromatic group at 5-position which inhibits a xanthine oxidase and is useful for treatment of gout and hyperuricemia can be obtained from compound (1) in a high yield without requiring isolation of reaction products in the course of reactions.Type: ApplicationFiled: July 23, 2004Publication date: August 24, 2006Applicant: FUJIYAKUHIN CO., LTD.Inventors: Hiroshi Nakamura, Junichiro Uda, Atsushi Ohno, Takahiro Sato
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Patent number: 6348461Abstract: The present invention provides 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid compounds and their addition salts, and processes for preparing them, which have antagonism against excitatory amino acid receptors, in particular, an AMPA receptor. The 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid compounds and their addition salts of the present invention are represented by formula (1) wherein Q, R, R1 and R2 are as described in the specification.Type: GrantFiled: March 1, 2000Date of Patent: February 19, 2002Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Yasuo Takano, Futoshi Shiga, Masanori Takadoi, Hideharu Uchiki, Jun Asano, Tsuyoshi Anraku, Kazunori Fukuchi, Junichiro Uda, Naoki Ando