Abstract: A train control device, according to one embodiment, includes a storage unit, an acquiring unit, and a control unit. The storage unit is configured to store therein information of a plurality of limit speeds corresponding to a plurality of respective blocks and being determined based on a block on which a preceding train traveling at least one ahead is located. The acquiring unit is configured to acquire schedule information of the preceding train indicating a time at which the preceding train exits each of the blocks. The control unit is configured to determine a limit speed in each of the blocks associated with a travel of a train, based on the acquired schedule information and the information of the limit speeds; and to create a travel plan of the train using the determined limit speed.

Abstract: The present invention pertains to a method for modifying a nucleic acid contained in a sample comprising a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and a method for selectively detecting a nucleic acid derived from living cells contained in the sample, comprising the following steps: (a) a step for modifying a nucleic acid contained in a sample according to the method for modifying a nucleic acid contained in a sample, which includes a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and (b) a step for selectively detecting an unmodified nucleic acid from the sample after step (a). The present invention further pertains to a kit and composition for use in these methods.

Abstract: The present invention pertains to: a method for modifying a nucleic acid contained in a sample, said method including a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and a method for selectively detecting a nucleic acid derived from living cells contained in the sample, said method including the following steps: (a) a step for modifying a nucleic acid contained in a sample according to the method for modifying a nucleic acid contained in a sample, which includes a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and (b) a step for selectively detecting an unmodified nucleic acid from the sample after step (a). The present invention further pertains to a kit and composition for use in these methods.

Abstract: The present invention pertains to: a method for modifying a nucleic acid contained in a sample, the method including a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and a method for selectively detecting a nucleic acid derived from living cells contained in the sample, the method including the following steps: (a) a step for modifying a nucleic acid contained in a sample according to the method for modifying a nucleic acid contained in a sample, which includes a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and (b) a step for selectively detecting an unmodified nucleic acid from the sample after step (a). The present invention further pertains to a kit and composition for use in these methods.

Abstract: A running curve creation device of an embodiment is a running curve creation device to create a running curve which can make a train having a prescribed vehicle characteristic run between a prescribed departure station and a prescribed arrival station in a prescribed running time with a smaller cumulative energy consumption. A shortest time running curve creation unit creates a shortest time running curve in which the train runs between the stations in a shortest time, based on predetermined vehicle information and ground information of the train, and an energy saving running curve creation unit selects from the shortest time running curve and a plurality of solution candidates corresponding to states of the train at each prescribed elapsed time since the train has departed from the departure station, a solution candidate having the relatively small cumulative energy consumption in the prescribed running time, and creates an energy saving running curve based on the selected solution candidate.

Abstract: An object of the present invention is to provide a simple and useful method for producing an RNA-containing probe for detecting a target nucleotide, a simple and useful method, device, and system for processing nucleotide sequence information, and a simple and useful method for detecting a target nucleotide. The present invention provides a method for processing nucleotide sequence information, the method comprising the step of generating partial nucleotide sequences which has 7 to 14 nucleotides and a Tm value of 25 to 40° C. and in which a target nucleotide or a nucleotide adjacent to the target nucleotide is located at a position between 3 and 5 nucleotides from the 3? or 5? end. The method according to the present invention is useful for simply and efficiently producing an RNA-containing probe for detecting a target nucleic acid, without the basis of researchers' experiences or guess, and are extremely useful not only in the field of genetic engineering, but also in the field of medical research.

Abstract: A train control device includes a detector that detects the current location and speed of the train, a clock unit that tracks the current time, a schedule input section by which the schedule data including the scheduled arrival time of the train at each station on the line is input, and a computing unit that computes an operating schedule according to which the train runs at the detected location and the detected speed to the next station, based on a target operation time that is obtained by subtracting the current time from the scheduled arrival time at the next station, operation characteristics of the train and a condition of the line.

Abstract: The present invention pertains to: a method for modifying a nucleic acid contained in a sample, said method including a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and a method for selectively detecting a nucleic acid derived from living cells contained in the sample, said method including the following steps: (a) a step for modifying a nucleic acid contained in a sample according to the method for modifying a nucleic acid contained in a sample, which includes a step for bringing the sample into contact with a nucleic acid-modifying agent in the presence of an acidic polysaccharide and/or a nucleotide; and (b) a step for selectively detecting an unmodified nucleic acid from the sample after step (a). The present invention further pertains to a kit and composition for use in these methods.

Abstract: An object of the present invention is to provide a simple and useful method for producing an RNA-containing probe for detecting a target nucleotide, a simple and useful method, device, and system for processing nucleotide sequence information, and a simple and useful method for detecting a target nucleotide. The present invention provides a method for processing nucleotide sequence information, the method comprising the step of generating partial nucleotide sequences which has 7 to 14 nucleotides and a Tm value of 25 to 40° C. and in which a target nucleotide or a nucleotide adjacent to the target nucleotide is located at a position between 3 and 5 nucleotides from the 3? or 5? end. The method according to the present invention is useful for simply and efficiently producing an RNA-containing probe for detecting a target nucleic acid, without the basis of researchers' experiences or guess, and are extremely useful not only in the field of genetic engineering, but also in the field of medical research.

Abstract: A train control device includes a first acquisition unit for acquiring a change history of open block numbers as the number of blocks existing between a present train and a leading train, a setting unit for setting a brake pattern having a starting point coinciding with an end point of a block existing just behind a block occupied by the leading train, and a calculating unit for calculating a time taken for the leading train to come out from the block existing just behind the block occupied by the leading train and for calculating, as a target speed, the highest speed available within a range not conflicting with the brake pattern.

Abstract: According to one embodiment, a train control system for a train is disclosed, the control system includes a speed detection unit configured to detect the train speed, a position detecting unit configured to detect position information of the train, a signal aspect speed receiver to receive signal aspect speed information from outside the train, an automatic train operation (ATO) unit that is configured to output a first throttle notch command to drive the train between stations and to stop the train at a target position, a specification notch pattern output unit configured to selectively output a second throttle notch control command. The signal aspect speed information includes a speed limit for a location. The first output throttle notch command is based, at least in part, on the signal aspect speed information.

Abstract: A train control device includes a first acquisition unit for acquiring a change history of open block numbers as the number of blocks existing between a present train and a leading train, a setting unit for setting a brake pattern having a starting point coinciding with an end point of a block existing just behind a block occupied by the leading train, and a calculating unit for calculating a time taken for the leading train to come out from the block existing just behind the block occupied by the leading train and for calculating, as a target speed, the highest speed available within a range not conflicting with the brake pattern.

Abstract: According to one embodiment, a train control system for a train is disclosed, the control system includes a speed detection unit configured to detect the train speed, a position detecting unit configured to detect position information of the train, a signal aspect speed receiver to receive signal aspect speed information from outside the train, an automatic train operation (ATO) unit that is configured to output a first throttle notch command to drive the train between stations and to stop the train at a target position, a specification notch pattern output unit configured to selectively output a second throttle notch control command. The signal aspect speed information includes a speed limit for a location. The first output throttle notch command is based, at least in part, on the signal aspect speed information.

Abstract: According to one embodiment, a vehicle controlling apparatus includes a storage unit, a setting unit, a changing unit, and a controller. The storage unit stores plurality sets of target information. The setting unit sequentially sets at least part of the plurality of target information to be satisfied until a vehicle stops in a given position based on the part of the plurality of target information. The changing unit sequentially changes one target information to next target information in series in the part of the plurality of target information when the one target information is satisfied. The controller which controls an operation of the vehicle so that the operation satisfies the target set by the changing unit.

Abstract: In the case where a template nucleic acid has sequences substantially the same as each other, a primer is designed in a region between these sequences so as to give a product in a ladder structure in which a target region is polymerized in a single sequence via the same sequences in the ICAN reaction. By using a chimeric oligonucleotide primer and a ladder-forming oligonucleotide primer containing a specific base sequence, an amplification product having a ladder structure can be positively formed and thus the sensitivity, amplification efficiency and reaction speed in the ICAN reaction can be elevated.

Abstract: A glycosidase inhibitor comprising as an active ingredient an extract of Ascophyllum nodosum which is a kind of brown algae can be used as a useful healthy food or food for specified health uses for the treatment and/or prevention of diabetes.

Abstract: A lipase inhibitor comprising as an active ingredient an extract of Ascophyllum nodosum which is a kind of brown algae can be used as a useful healthy food or food for specified health uses for the treatment and/or prevention of obesity or hyperlipemia.

Abstract: A convenient and effective method for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers; a method for supplying a large amount of DNA amplification fragments; an effective method for amplifying a nucleic acid sequence by combining the above method with another nucleic acid sequence amplification method; a method for detecting a nucleic acid sequence for detecting or quantitating a microorganism such as a virus, a bacterium, a fungus or a yeast; and a method for detecting a DNA amplification fragment obtained by the above method in situ.

Abstract: A convenient and effective method for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers; a method for supplying a large amount of DNA amplification fragments; an effective method for amplifying a nucleic acid sequence by combining the above method with another nucleic acid sequence amplification method; a method for detecting a nucleic acid sequence for detecting or quantitating a microorganism such as a virus, a bacterium, a fungus or a yeast; and a method for detecting a DNA amplification fragment obtained by the above method in situ.

Abstract: A method for synthesizing cDNA characterized by performing a reverse transcription reaction in the presence of an enzyme having a reverse transcriptional activity and another enzyme different from the former one which as a 3?-5? exonuclease activity.