Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The present disclosure relates to a device and a system for testing flatness. The device for testing flatness includes a base, a testing platform, and a ranging sensor. The testing platform is assembled on the base. The testing platform includes a supporting structure. The supporting structure is disposed on the side of the testing platform away from the base and is used to support a to-be-tested board. The structure matches the structure of the to-be-tested board. The ranging sensor is disposed on the side of the testing platform away from the base. After the to-be-tested board is placed on the testing platform, the ranging sensor is used to test distances between a number N of to-be-tested positions on the to-be-tested board and the ranging sensor, to obtain N pieces of distance information, and the N pieces of distance information are used to determine the flatness of the to-be-tested board, where N is an integer greater than 2.

Abstract: The present disclosure describes a system and method for encoding pulses of light for LiDAR scanning. The system includes a sequence generator, a light source, a modulator, a light detector, a correlator, and a microprocessor. The sequence generator generates a sequence code that the modulator encodes into a pulse of light from the light source. The encoded pulse of light illuminates a surface of an object, in which scattered light from the encoded light pulse is detected. The correlator correlates the scattered light with the sequence code that outputs a peak value associated with a time that the pulse of light is received. The microprocessor is configured to determine a time difference between transmission and reception of the pulse of light based on whether the amplitude of the peak exceeds the threshold value. The microprocessor calculates a distance to the surface of the object based on the time difference.

Abstract: A light ranging and detection (LiDAR) system is provided. The LiDAR system comprises metasurface-based optics. The system comprises a transmitter comprising one or more transmitter optics. The transmitter is configured to provide one or more transmission light beams. The system further comprises a beam steering apparatus optically coupled to the transmitter. The beam steering apparatus comprises one or more steering optics configured to: scan the one or more transmission light beams in at least one of a horizontal and a vertical directions to a field-of-view, and direct return light formed based on the scanned one or more transmission light beams. The system further comprises a receiver comprising one or more receiver optics. At least one of the one or more transmitter optics, the one or more steering optics, and the one or more receiver optics comprise the one or more metasurface-based optics.

Abstract: Embodiments of the present disclosure provide stray light filter structures in light detection and ranging (LiDAR) systems to attenuate stray light and reduce unwanted scattering. In some embodiments, a micro lens array is used together with a pinhole array to block stray light in the optical path just prior to the photodetector. In some embodiments, a bandpass optical filter is used in the optical path prior to the microlens array. In other embodiments, a slit filter is used further upstream in the optical path to block unwanted stray light and allow returning signal light to pass to imaging optics that provide a returning signal light image at a photodetector. In some embodiments, the imaging optics include a collimating lens and a focusing lens. In some embodiments, an optical bandpass filter is positioned on the optical path between the collimating lens and the focusing lens to reject light that is outside of a an expected wavelength range for returning signal light.

Abstract: Embodiments discussed herein refer to LiDAR systems and methods that use a virtual window to monitor for potentially unsafe operation of a laser. If an object is detected within the virtual window, the LiDAR system can be instructed to deactivate laser transmission.

Abstract: A method for determining the pore size and pore size distribution of a filtration membrane comprises: selecting a group of fluorescent pellets having different diameters and emission wavelengths as a reference; plotting the standard curve between the concentration and fluorescence intensity for each fluorescent pellet at its emission wavelength; uniformly dispensing a group of fluorescent pellets as a reference substance in water to prepare a mixed suspension of which the mass concentration of each fluorescent pellet; using the filter membrane to be tested to perform one-time filtration on the mixed suspension prepared, then performing fluorescence detection on the obtained filtrate, calculating the concentration of each fluorescent pellet in the filtrate the retention rate of the filtration membrane to be tested for each fluorescent pellet; and calculating the pore size and pore size distribution of the filter membrane to be tested accordingly.

Abstract: Embodiments discussed herein refer to LiDAR systems that use diode lasers to generate a high-repetition rate and multi-mode light pulse that is input to a fiber optic cable that transmits the light pulse to a scanning system.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: LiDAR system and methods discussed herein use a dispersion element or optic that has a refraction gradient that causes a light pulse to be redirected to a particular angle based on its wavelength. The dispersion element can be used to control a scanning path for light pulses being projected as part of the LiDAR's field of view. The dispersion element enables redirection of light pulses without requiring the physical movement of a medium such as mirror or other reflective surface, and in effect further enables at least portion of the LiDAR's field of view to be managed through solid state control. The solid state control can be performed by selectively adjusting the wavelength of the light pulses to control their projection along the scanning path.

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Abstract: Systems, methods, and devices for treating vascular defects are disclosed herein. In some embodiments, a device for treating an aneurysm includes a plurality of braided filaments configured to be implanted in an aneurysm cavity.

Abstract: A device for treating an intracranial aneurysm in accordance with an embodiment of the present technology includes an elongate conduit body defining an axial lumen through which the conduit body is configured to convey liquid embolic material toward the aneurysm. The conduit body includes a first flexibility zone defining a first average bending stiffness and a first outer diameter. The conduit body further includes a second flexibility zone distal to the first flexibility zone and defining a second average bending stiffness and a second outer diameter. The second average bending stiffness and the second outer diameter are less than the first average bending stiffness and the first outer diameter, respectively. The conduit body also includes a transition zone between the first and second flexibility zones. The transition zone defines a third outer diameter that transitions proximally-to-distally from the first outer diameter to the second outer diameter.

Abstract: Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.

Abstract: A method for treating an aneurysm in accordance with a particular embodiment of the present technology includes intravascularly delivering a mixture including a biopolymer (e.g., chitosan) and a chemical crosslinking agent (e.g., genipin) to an aneurysm. The method further includes mixing the biopolymer and the chemical crosslinking agent to initiate chemical crosslinking of the biopolymer. The mixture is delivered to the aneurysm via a lumen and an exit port of a catheter while the chemical crosslinking is ongoing. The mixture exits the catheter as a single cohesive strand that at least partially agglomerates to form a mass occupying at least 75% of a total internal volume of the aneurysm. During delivery of the mixture, the method includes expanding a tubular flow diverter to reinforce a neck of the aneurysm.

Abstract: Devices, systems, and methods for treating aneurysms are disclosed herein. According to some embodiments, the present technology includes a treatment system comprising a delivery shaft, a manipulation shaft slidably positioned within the lumen of the delivery shaft, and an occlusive device configured for implantation within the aneurysm. The occlusive device can comprise a plurality of filaments that are secured to one another at a proximal end of the occlusive device by a cured material. The occlusive device can comprise inner and outer layers of braided filaments, wherein the proximal end region of the inner layer has an exposed portion that extends proximally beyond the proximal end region of the outer layer, and wherein the cured material extends into and fills interstices between the braided filaments at the proximal end regions of the inner and outer layers.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

Abstract: A method for treating an aneurysm in accordance with a particular embodiment of the present technology includes intravascularly delivering a mixture including a biopolymer (e.g., chitosan) and a chemical crosslinking agent (e.g., genipin) to an aneurysm. The method further includes mixing the biopolymer and the chemical crosslinking agent to initiate chemical crosslinking of the biopolymer. The mixture is delivered to the aneurysm via a lumen and an exit port of a catheter while the chemical crosslinking is ongoing. The mixture exits the catheter as a single cohesive strand that at least partially agglomerates to form a mass occupying at least 75% of a total internal volume of the aneurysm. During delivery of the mixture, the method includes expanding a tubular flow diverter to reinforce a neck of the aneurysm.