Abstract: Compounds of general formula I 1

Abstract: Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.

Abstract: These invention relates to metal-complexing, cysteine-free peptides which may be coupled to an organ-specific probe directly or via a linker and are thus enriched as conjugates specifically in tumors, organs, tissues or centers of inflammation. The organ-specific probes used are, for example, antibodies or part-sequences of antibodies against tumor-associated antigens, e.g. the carcino-embryonal antigen (CEA, which are thus specifically enriched in tumors. The invention also relates to processes for producing the metal-complexing cysteine-free peptides and their conjugates. The present invention also relates to the use of the conjugates as components of a kit for in vivo diagnosis or in vivo therapy and radio-pharmaceuticals containing these conjugates together with radio-isotopes. The organ-specific conjugates are used to image tumors, organs or centers of inflammation.

Abstract: Chelate compounds of general formula I wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1, R2, R3 and R4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.

Abstract: The invention relates to new 1,4,7,10-tetraazacyclododecane derivatives of formula I ##STR1## in which R.sup.1, R.sup.2, X and V have various meanings, their metal complexes, pharmaceutical agents containing these compounds, their use in diagnosis and treatment as well as process for the production of these compounds and agents.

Abstract: Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.

Abstract: The invention relates to new 3,8-substituted deuteroporphyrin derivatives with various substituents in positions 13 and 17 of the porphyrin skeleton, pharmaceutical agents containing these compounds, their use in diagnosis and therapy as well as process for the production of these agents.

Abstract: Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, andZ.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.

Abstract: Compounds of a general Formula I ##STR1## wherein Z.sup.1 and Z.sup.2 in each case independently mean the residue--(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.1 --(O).sub.r --R,whereinm and n means the numbers 0-20, k, l, q and r means the numbers 0 and 1, andR means a hydrogen atom, an optionallyOR.sup.1 -substituted C.sub.1 -C.sub.6 -alkyl residue, or aCH.sub.2 COOR.sup.1 group with R.sup.1 meaning a hydrogen atom,a C.sub.1 -C.sub.6 -alkyl residue, or a benzyl group,X means a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21-29, 42, 44 or 57-83,with the provisos that at least two the substituents X stand for a metal ion equivalent; that one of the substituents Z.sup.1 and Z.sup.2 stands for a hydrogen and the other is not H; that--if n and 1 each mean the number 0--k and r do not simultaneously mean the number 1; that--(O).sub.r --R is not --OH; and that Z.sup.1 and Z.sup.2 are not --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.

Abstract: 1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4,X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83,R.sup.1 and R.sup.2, being different, mean in each case a hydrogen atom or a straight-chain, branched, saturated or unsaturated C.sub.0 -C.sub.20 -alkylene group, this alkylene group exhibiting at the end either a second molecule of general Formula I.sub.A or I.sub.

Abstract: Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuable complexing agents and complexes for diagnosis.

Abstract: Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuable complexing agents and complexes for diagnosis.

Abstract: Porphyrin complex compounds consisting of a meso-tetraphenylporphyrin ligand of general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have varying meanings, and an ion of an element of atomic numbers 21-32, 38, 39, 42-51 or 58-83 as well as optionally one or more physiologically harmless cation(s) of inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic agents.

Abstract: Complex compounds of general Formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of at least one element of atomic numbers 21-29, 42, 44 or 58-70, with at least two of the substituents X representing a metal ion equivalent, andR.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and n are defined herein, as well as their salts with organic and/or inorganic bases, are valuable compounds for organ-specific NMR diagnostics.

Abstract: Porphyrin complex compounds, consisting of a mesotetraphenylporphyrin ligand, optionally at least one ion of an element with atomic numbers 13, 21, 32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic and therapeutic agents.

Abstract: Porphyrin complex compounds consisting of at least one porphyrin ligand, optionally at least one ion of an element of atomic numbers 5, 13, 21-32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic media and therapeutic agents.

Abstract: An apparatus for the treatment of workpieces by means of temperature and pressure shocks through the ignition of a combustible gas mixture, particularly a thermal deburring system, is proposed whose workpiece treatment chamber (1, 21, 34) consists of an outer hollow member (3, 22, 35) and an inner hollow member (4, 29, 37) which are guided one into the other and are arranged so as to be movable relative to one another, the inner hollow member (4, 29, 37) having at least one combustion space (10, 31, 32, 39, 40) for receiving the workpieces, which combustion space (10, 31, 32, 39, 40) can be brought into the area of a wall (5, 23) of the outer hollow member closing the combustion space by means of a relative movement of the two hollow members.

Abstract: A mixing block (40) for mixing a combustible gas mixture, consisting of at least two components, for processing materials by means of temperature and pressure concussions, particularly for thermal deburring apparatuses, is suggested, having a gas feed borehole (43 and 44) for each gas component, opening into a mixing and ignition duct (61, 68, 69, 73, 74, 75), wherein a main valve (48, 49, 50, 51 and 52, 53) for admitting the gas components into the mixing and ignition duct (61, 68, 69, 73, 74, 75) and for closing the gas feed boreholes (43 and 44) so as to be gas-tight during the combustion process is arranged in each gas feed borehole (43 and 44).

Abstract: A gas feeding device is suggested which is used for feeding a combustible gas mixture consisting of at least two components into a combustion chamber of a thermic deburring installation for treating work pieces (3) by means of temperature and pressure shocked formed by igniting the gas mixture. The device includes a control circuit used as a dosaging device which is adjustable to different mixing ratios. The central circuit includes a through flow amount meter in each of the gas feeding lines, a measuring value comparator (31) and a dosaging valve controlled by the measuring value comparator in one of the feeding lines. Shut-off valves are provided in the feeding lines between the flow amount meters and the combustion chamber which react to a signal issued by a storage or counting device connected to one of the flow amount meters (24 or 29) in response to the flow of a preselectable amount of gas.

Abstract: A mixing arrangement for mixing a combustible gas mixture consisting of at least two gas components for treatment of materials by means of temperature and pressure shocks, comprises for each gas component a feeding line discharging into a mixing chamber. At the discharge area of each of the feeding lines a jet arrangement is provided which forces gas flows discharged from the jet arrangement to take a shape and direction which enhance the admixture thereof before they enter the mixing chamber.