Abstract: A solid or semisolid, at least two-phase active ingredient-containing formulation in which there is multiparticulate incorporation of one of the two phases into a matrix of the other phase, and at least one of the phases contains at least one active ingredient, obtainable by introducing particles of one phase into the other phase in a plastic state, and shaping the material while still plastic.

Abstract: Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.

Abstract: Solid, elongate dosage forms (10) with a long axis (11) and with a length (L) which is defined by projection of the ends (12, 13) of the dosage form to the long axis, where a cross-sectional area (14, 15, 16) oriented perpendicular to the long axis (11) has an area which is variable along the long axis (11) and increases from a cross-sectional area (15) which is located between the ends (12, 13) and has a minimal area essentially continuously toward the two ends (12, 13) up to in each case a cross-sectional area (14 and 16 respectively) with a maximal area, wherein the distance of the maximal cross-sectional area (14) which is located near one end (12) from the maximal cross-sectional area (16) which is located near the other end (13) is, projected on the long axis (11), more than half the length (L) of the dosage form (10), are described.

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients, A) 10-90% by weight of a melt-processable, water-soluble polymer, B) 5-85% by weight of isomalt, and C) 0-5% by weight of lecithin, where the total of all the ingredients is to be equal to 100% by weight.

Abstract: A process for producing solid combination tablets which have at least two phases comprises molding a melt of a polymeric binder with or without at least one active ingredient, there being at least one solid product, which may contain an active ingredient incorporated into the still plastic composition during the molding step.

Abstract: A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.

Abstract: A level boom is provided for a piece of strip mining equipment traveling on caterpillar-type chassis, which piece of equipment is temporarily moved on oblique roadways during operation. The position of the boom in relation to the skeletal structure is corrected with simple means. A piece of strip mining equipment with a boom, which can be lifted and lowered and at the free end of which, e.g., a bucket wheel for picking up a load is arranged, is connected to the substructure of the piece of equipment in a pivot axis. The lifting movement is brought about by a lifting cylinder. A tilting support, which carries the boom, is arranged in the pivot axis for lifting and lowering the boom. A bolt connection is provided on one side in the pivot axis for leveling between the tilting support and the boom, and the actuating element for leveling as well as a step bearing for absorbing lateral forces which the actuating element is unable to absorb, are located on the other side.