Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: Systems, apparatuses, and methods for providing content using notifications with content-specific keywords are provided. In one example embodiment, a method includes identifying, by one or more computing devices, a media content item for a user of a user device. The method includes generating, by the one or more computing devices, a keyword for the user of the user device based at least in part on data associated with the media content item. The keyword is indicative of the media content item. The method includes providing, by the one or more computing devices to the user device, for display a notification indicating that the media content is available for the user. The notification includes the keyword and the keyword is viewable by the user.

Abstract: Systems, apparatuses, and methods for providing content using notifications with content-specific keywords are provided. In one example embodiment, a method includes identifying, by one or more computing devices, a media content item for a user of a user device. The method includes generating, by the one or more computing devices, a keyword for the user of the user device based at least in part on data associated with the media content item. The keyword is indicative of the media content item. The method includes providing, by the one or more computing devices to the user device, for display a notification indicating that the media content is available for the user. The notification includes the keyword and the keyword is viewable by the user.

Abstract: Systems, apparatuses, and methods for providing content using notifications with content-specific keywords are provided. In one example embodiment, a method includes identifying, by one or more computing devices, a media content item for a user of a user device. The method includes generating, by the one or more computing devices, a keyword for the user of the user device based at least in part on data associated with the media content item. The keyword is indicative of the media content item. The method includes providing, by the one or more computing devices to the user device, for display a notification indicating that the media content is available for the user. The notification includes the keyword and the keyword is viewable by the user.