Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: Disclosed herein are systems and methods for treating a magnesium or a magnesium alloy substrate. The system includes a cleaning composition having a pH greater than 8.5 or a solvent, and a pretreatment composition comprising an organophosphate compound and/or an organophosphonate compound. The method includes contacting a substrate surface with the cleaning composition or the solvent, and contacting the surface with the pretreatment composition. Also disclosed are substrates treated with one of the systems or methods. Also disclosed are magnesium or magnesium alloy substrates wherein, between the air/substrate interface and 500 nm below the air/substrate interface (a) oxygen and magnesium are present in a combined amount of at least 70 atomic %; (b) carbon is present in an amount of no more than 30 atomic %; and/or (c) fluoride is present in an amount of no more than 8 atomic %, wherein atomic % is measured by XPS depth profiling.

Abstract: Disclosed herein are systems and methods for treating a metal substrate. The system includes a first pretreatment composition comprising a fluorometallic acid and free fluoride and having a pH of 1.0 to 4.0 and a second pretreatment composition comprising a Group IVB metal or a third pretreatment comprising a lanthanide series metal and an oxidizing agent. The method includes contacting at least a portion of a surface of the substrate with the first pretreatment composition and optionally contacting at least a portion of the substrate surface with the second pretreatment composition or the third pretreatment composition. Also disclosed are substrates treated with one of the systems or methods. Also disclosed are magnesium or magnesium alloy substrates comprising a bilayer comprising a first layer comprising silicone and a second layer comprising fluoride.

Abstract: Disclosed is a system for treating a surface of a multi-metal article. The system includes first and second and/or third conversion compositions for contacting at least a portion of the surface. The first conversion composition includes phosphate ions and zinc ions and is substantially free of fluoride. The second conversion composition includes a lanthanide series metal cation and an oxidizing agent. The third conversion composition includes an organophosphate compound, an organophosphonate compound, or combinations thereof that optionally may include at least one transition metal. Methods of treating a multi-metal article using the system also are disclosed. Also disclosed are substrates treated with the system and method.

Abstract: Disclosed is a system for treating a metal substrate comprising a conversion composition comprising trivalent chromium in an amount of 0.001 g/L to 20 g/L and a sealing composition comprising an ammonium-containing compound. Also disclosed is a method for treating a metal substrate that includes contacting at least a portion of a surface of the substrate with the conversion composition and then contacting at least a portion of the surface of the substrate with the sealing composition. Also disclosed is a substrate obtainable by treatment with the system and/or obtainable by the method of treatment.

Abstract: The present invention is directed towards an aqueous alkaline cleaner composition comprising: an iron cation, a molybdenum cation, a cobalt cation, or combinations thereof; and an alkaline component; wherein the pH of the aqueous alkaline composition is at least 10, and the aqueous alkaline composition includes no more than 50 ppm of phosphate. Also disclosed are treatment systems comprising an aqueous alkaline composition for treating at least a portion of a substrate, and a pretreatment composition for treating at least a portion of a substrate. Also disclosed are substrates treated according to the disclosed treatment systems.

Abstract: The present invention is directed to a coated substrate comprising: (a) a surface that has been impacted with an abrasive particle and a dopant such that at least some portion of the surface becomes attached with the dopant; and (b) a film-forming layer on at least a portion of the impacted surface, wherein the film-forming layer has been deposited from a film-forming composition; wherein the surface is impacted substantially simultaneously with the abrasive particle and the dopant; and wherein when the dopant comprises iron phosphate, zinc phosphate, manganese phosphate, cerium oxide, the film-forming composition is not a two-component epoxy clear coat.

Abstract: Disclosed is a method of treating a substrate, comprising contacting at least a portion of the substrate surface with a first composition comprising a lanthanide source and an oxidizing agent. A substrate obtainable by the methods also is disclosed.

Abstract: The present invention includes a process for producing treated filler that includes (a) treating a slurry that includes untreated filler, where the untreated filler has not been previously dried, with a treating composition that includes a treating agent, thereby forming a treated filler slurry, and (b) drying the treated filler slurry to produce treated filler. The treating agent can include a polymer having (i) at least one first group that interacts with the untreated filler and (ii) at least one second group that interacts with a rubber matrix into which the treated filler is incorporated. The present invention also is directed to treated filler prepared by the process, as well as rubber compounding compositions and tires including the treated filler.

Abstract: The present invention includes a process for producing treated filler that includes (a) treating a slurry that includes untreated filler, where the untreated filler has not been previously dried, with a treating composition that includes a treating agent, thereby forming a treated filler slurry, and (b) drying the treated filler slurry to produce treated filler. The treating agent can include a polymer having (i) at least one first group that interacts with the untreated filler and (ii) at least one second group that interacts with a rubber matrix into which the treated filler is incorporated. The present invention also is directed to treated filler prepared by the process, as well as rubber compounding compositions and tires including the treated filler.

Abstract: Disclosed is a system for treating a surface of a multi-metal article. The system includes first and second and/or third conversion compositions for contacting at least a portion of the surface. The first conversion composition includes phosphate ions and zinc ions and is substantially free of fluoride. The second conversion composition includes a lanthanide series metal cation and an oxidizing agent. The third conversion composition includes an organophosphate compound, an organophosphonate compound, or combinations thereof that optionally may include at least one transition metal. Methods of treating a multi-metal article using the system are disclosed. Also disclosed are substrates treated with the system and method.

Abstract: The present invention is directed towards an aqueous alkaline cleaner composition comprising: an iron cation, a molybdenum cation, a cobalt cation, or combinations thereof; and an alkaline component; wherein the pH of the aqueous alkaline composition is at least 10, and the aqueous alkaline composition includes no more than 50 ppm of phosphate. Also disclosed are treatment systems comprising an aqueous alkaline composition for treating at least a portion of a substrate, and a pretreatment composition for treating at least a portion of a substrate. Also disclosed are substrates treated according to the disclosed treatment systems.

Abstract: Disclosed herein is a system for treating a substrate. The system includes a pretreatment composition for treating at a least a portion of the substrate, the pretreatment composition comprising a Group IVB metal cation; and a sealing composition for treating at least a portion of the substrate treated with the pretreatment composition, the sealing composition comprising a Group IA metal cation. Also disclosed are methods of treated a substrate with the system. Also disclosed are substrates treated with the system and method.

Abstract: Disclosed is a system for treating a surface of a multi-metal article. The system includes first and second compositions for contacting at least a portion of the surface. The first composition includes phosphate ions and zinc ions and is substantially free of fluoride. The second composition includes a lanthanide series metal cation and an oxidizing agent. Methods of treating a multi-metal article using the system also are disclosed. Also disclosed are substrates treated with the system and method.

Abstract: The present invention includes a process for producing treated filler that includes (a) treating a slurry that includes untreated filler, where the untreated filler has not been previously dried, with a treating composition that includes a treating agent, thereby forming a treated filler slurry, and (b) drying the treated filler slurry to produce treated filler. The treating agent can include a polymer having (i) at least one first group that interacts with the untreated filler and (ii) at least one second group that interacts with a rubber matrix into which the treated filler is incorporated. The present invention also is directed to treated filler prepared by the process, as well as rubber compounding compositions and tires including the treated filler.

Abstract: The present invention includes a process for producing treated filler that includes (a) treating a slurry that includes untreated filler, where the untreated filler has not been previously dried, with a treating composition that includes a treating agent, thereby forming a treated filler slurry, and (b) drying the treated filler slurry to produce treated filler. The treating agent can include a polymer having (i) at least one first group that interacts with the untreated filler and (ii) at least one second group that interacts with a rubber matrix into which the treated filler is incorporated. The present invention also is directed to treated filler prepared by the process, as well as rubber compounding compositions and tires including the treated filler.

Abstract: The present invention is directed to a separation medium comprising rotary dried or spray dried precipitated silica. The silica has a pore surface area P wherein log10 P>2.2, and the ratio of BET to CTAB is at least 1.0 measured prior to any surface modification of the silica. The present invention is further directed to a method of separating suspended or dissolved materials from a fluid stream, comprising contacting the stream with the separation medium described above.

Abstract: The present invention is directed to a process for producing treated filler including (a) treating a slurry of untreated filler which has not been previously dried, with a treating composition including an organosilane material of specified structure (I); and (b) drying the treated filler slurry. The present invention also is directed to treated filler prepared by the process, as well as rubber compounding compositions and tires including the treated filler.

Abstract: Rubber formulations comprising a base rubber composition, graphenic carbon particles, and non-conductive filler particles such as silica are disclosed. The formulations possess favorable properties such as relatively low surface resistivities, and are useful for many applications such as tire treads.

Abstract: The present invention is directed to microfiltration membranes comprising a microporous material, said microporous material comprising: (a) a polyolefin matrix present in an amount of at least 2 percent by weight, (b) finely divided, particulate, substantially water-insoluble silica filler distributed throughout said matrix, said filler constituting from about 10 percent to about 90 percent by weight of said microporous material substrate, wherein the weight ratio of filler to polyolefin is greater than 4:1; and (c) at least 35 percent by volume of a network of interconnecting pores communicating throughout the microporous material. The present invention is also directed to methods of separating suspended or dissolved materials from a fluid stream such as a liquid or gaseous stream, comprising passing the fluid stream through the microfiltration membrane described above.