Patents by Inventor Justin Klesmith

Justin Klesmith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD19 variants
    Patent number: 11891426
    Abstract: CD19 variants, methods of identifying CD19 variants, and methods of using such CD19 variants, e.g., for treating cancer, are described.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 6, 2024
    Assignees: Aleta Biotherapeutics Inc., Regents of The University of Minnesota
    Inventors: Roy Lobb, Paul Rennert, Benjamin Hackel, Justin Klesmith
  • Methods for generating single- or multi-site mutagenesis
    Patent number: 11155811
    Abstract: Deep mutational scanning is a foundational tool for addressing functional consequences of large numbers of mutants, yet a more efficient and accessible method for construction of user-defined mutagenesis libraries is needed. Provided herein are nicking saturation mutagenesis, a single-day, single-pot saturation mutagenesis method using routinely prepped plasmid dsDNA as input substrate. Reproducibility and convenience of the method are demonstrated through validation by an external research laboratory.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 26, 2021
    Assignee: Board of Trustees of Michigan State University
    Inventors: Justin Klesmith, James Stapleton, Timothy Whitehead, Emily Wrenbeck
  • CD19 VARIANTS
    Publication number: 20210079060
    Abstract: CD19 variants, methods of identifying CD19 variants, and methods of using such CD19 variants, e.g., for treating cancer, are described.
    Type: Application
    Filed: December 14, 2018
    Publication date: March 18, 2021
    Inventors: Roy Lobb, Paul Rennert, Benjamin Hackel, Justin Klesmith
  • METHODS FOR GENERATING SINGLE-OR MULTI-SITE MUTAGENESIS
    Publication number: 20190062733
    Abstract: Deep mutational scanning is a foundational tool for addressing functional consequences of large numbers of mutants, yet a more efficient and accessible method for construction of user-defined mutagenesis libraries is needed. Provided herein are nicking saturation mutagenesis, a single-day, single-pot saturation mutagenesis method using routinely prepped plasmid dsDNA as input substrate. Reproducibility and convenience of the method are demonstrated through validation by an external research laboratory.
    Type: Application
    Filed: August 28, 2018
    Publication date: February 28, 2019
    Inventors: Justin Klesmith, James Stapleton, Timothy Whitehead, Emily Wrenbeck