Patents by Inventor Justin L. Neill
Justin L. Neill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240085286Abstract: Molecular rotational resonance (MRR) spectroscopy can be used to characterize neutral, gas-phase molecules with very fine spectral resolution. Typically, the analyte molecules are placed in solution, which is heated initially to evaporate the solvent, then heated more to volatilize the analyte. Unfortunately, this approach does not always work well for analytes with low volatilities or susceptibility to thermal degradation. These analytes can be volatilized instead using laser-induced acoustic desorption (LIAD), flash vaporization, or nebulization. In LIAD, the analyte is dried onto a metal foil, which is illuminated by a laser. The laser beam generates an acoustic wave in the metal foil that shakes off the analyte. In flash vaporization, a small amount of liquid analyte drips onto a very hot surface, where it vaporizes too quickly to degrade. And in nebulization, a nebulizer pumps a fine spray of analyte into a heated transfer tube, where the solvent evaporates.Type: ApplicationFiled: November 20, 2023Publication date: March 14, 2024Applicant: BrightSpec, Inc.Inventors: Voislav Blagojevic, Chris Thompson, Justin L. Neill
-
Publication number: 20220196582Abstract: The capabilities of a gas or liquid chromatography-molecular rotational resonance (GC/LC-MRR) instrument exceed those of high-resolution mass spectrometry and nuclear magnetic resonance in terms of selectivity, resolution, and compound identification. MRR detection provides high specificity for selective gas- or liquid-phase separations, including the ability to resolve co-eluting peaks and isomeric compounds without any loss of specificity or accuracy. MRR can perform both qualitative identification and absolute quantification of analyte components separated by GC or LC without a reference standard. GC-MRR is ideal for compound-specific isotope analysis (CSIA) and can identify enantiomers and enantiomeric excess. GC-MRR measurements are especially useful for studying biosynthetic/degradation and geochemical isotopic compounds.Type: ApplicationFiled: May 7, 2020Publication date: June 23, 2022Applicant: BrightSpec, Inc.Inventors: Justin L. Neill, Matt Muckle, Alexander V. Mikhonin, Walter H. Colsman, Daniel W. Armstrong
-
Publication number: 20210302340Abstract: Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation.Type: ApplicationFiled: August 8, 2019Publication date: September 30, 2021Inventors: Justin L. Neill, Matt Muckle, Roger Reynolds
-
Patent number: 11029261Abstract: Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.Type: GrantFiled: March 3, 2020Date of Patent: June 8, 2021Assignee: BrightSpec, Inc.Inventors: Justin L. Neill, Brent Harris, Brooks Hart Pate
-
Publication number: 20200209170Abstract: Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.Type: ApplicationFiled: March 3, 2020Publication date: July 2, 2020Inventors: Justin L. Neill, Brent HARRIS, Brooks Hart Pate
-
Patent number: 10620138Abstract: Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.Type: GrantFiled: June 28, 2018Date of Patent: April 14, 2020Assignee: BrightSpec, Inc.Inventors: Justin L. Neill, Brent Harris, Brooks Hart Pate
-
Patent number: 10222262Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: GrantFiled: August 31, 2017Date of Patent: March 5, 2019Assignee: University of Virginia Patent FoundationInventors: Brooks Hart Pate, Justin L. Neill
-
Publication number: 20190033235Abstract: Methods and apparatuses for direct multiplication Fourier transform millimeter wave spectroscopy are disclosed herein. A sample method includes generating at least one pulse of microwave electromagnetic energy. The sample method also includes frequency-multiplying the pulse(s) to generate at least one frequency-multiplied pulse and filtering at least one spurious harmonic of the frequency-multiplied pulse to generate at least one filtered pulse. The spurious harmonic is generated by frequency-multiplying the pulse. The method also includes exciting a sample using the filtered pulse. The method further includes detecting an emission from the sample. The emission is elicited at least in part by the filtered pulse.Type: ApplicationFiled: June 28, 2018Publication date: January 31, 2019Inventors: Justin L. Neill, Brent HARRIS, Brooks Hart Pate
-
Publication number: 20180052051Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: ApplicationFiled: August 31, 2017Publication date: February 22, 2018Inventors: Brooks Hart Pate, Justin L. Neill
-
Patent number: 9778112Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: GrantFiled: October 31, 2016Date of Patent: October 3, 2017Assignee: University of Virginia Patent FoundationInventors: Brooks Hart Pate, Justin L. Neill
-
Publication number: 20170176256Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: ApplicationFiled: October 31, 2016Publication date: June 22, 2017Inventors: Brooks Hart Pate, Justin L. Neill
-
Patent number: 9482577Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: GrantFiled: September 23, 2014Date of Patent: November 1, 2016Assignee: University of Virginia Patent FoundationInventors: Brooks Hart Pate, Justin L. Neill
-
Publication number: 20150260575Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: ApplicationFiled: September 23, 2014Publication date: September 17, 2015Inventors: Brooks Hart Pate, Justin L. Neill
-
Patent number: 8873043Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: GrantFiled: June 7, 2013Date of Patent: October 28, 2014Assignee: University of Virginia Patent FoundationInventors: Brooks Hart Pate, Justin L. Neill
-
Publication number: 20130265573Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.Type: ApplicationFiled: June 7, 2013Publication date: October 10, 2013Applicant: University of Virginia Patent FoundationInventors: Brooks Hart Pate, Justin L. Neill