Abstract: Provided herein are compositions, systems, kits, and methods for performing an activity based on detecting, in a sample from a cancer patient, the presence of elevated levels of Lactotransferrin (LTF) mRNA or protein, or detecting the presence in the MIF promoter region of at least one of: ?173C and ?794 CATT5-8, and treating a patient with immunotherapy, or generating a report that the subject should be treated with immunotherapy.

Abstract: Disclosed herein are compositions and methods for treating glioblastoma in a patient in need thereof by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof, and an immune checkpoint inhibitor.

Abstract: The invention concerns substrates comprising a biocompatible gel and at least one of a plurality of cells, said cells being capable of producing at least one therapeutic agent. Other aspects of the invention concern methods of making such substrates and methods of repairing and regenerating damaged nervous tissue with the substrates.

Abstract: A method for producing surfactant-stabilized microcapsules or nanocapsules including the steps of (a) preparing a suspension comprising a non-ionic sorbitan detergent and a salt in phosphate buffered saline; (b) adding to the suspension a nonionic polyoxyethylenesorbitan detergent to produce a solution; (c) heating while stirring the solution of step (b) to 55±5° C. and maintaining the temperature of the solution at 55±5° C. for several minutes; (d) allowing the solution to cool to room temperature; (e) autoclaving the solution; (f) creating surfactant-stabilized microbubbles and nanobubbles in the solution; and (g) collecting surfactant-stabilized nanocapsules and microcapsules formed from the microbubbles and nanobubbles.

Abstract: Methods for producing surfactant-stabilized and polymer-based microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided.

Abstract: Methods for producing polymer-based microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided. Methods for enhancing delivery of nanocapsules via ultrasound are also provided.