Patents by Inventor Jutta Kroeber

Jutta Kroeber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of ()-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
    Patent number: 9242965
    Abstract: The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I wherein R1 and R2 independently denote C1-3-alkyl groups and X? denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 26, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Juncheng Zheng, Da Deng, Guanghua Lv, Jun Yan, Joerg Brandenburg, Jutta Kroeber, Ulrich Scholz
  • PROCESS FOR THE MANUFACTURE OF (E)-4-N,N-DIALKYLAMINO CROTONIC ACID IN HX SALT FORM AND USE THEREOF FOR SYNTHESIS OF EGFR TYROSINE KINASE INHIBITORS
    Publication number: 20150183764
    Abstract: The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I wherein R1 and R2 independently denote C1-3-alkyl groups and X? denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.
    Type: Application
    Filed: December 19, 2014
    Publication date: July 2, 2015
    Inventors: Juncheng ZHENG, Da Deng, Guanghua LV, Jun Yan, Joerg Brandenburg, Jutta Kroeber, Ulrich Scholz
  • Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Publication number: 20090088571
    Abstract: Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Application
    Filed: December 5, 2008
    Publication date: April 2, 2009
    Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
    Inventors: Xiao-jun WANG, Thomas WIRTH, Thomas NICOLA, Li ZHANG, Rogelio Perez FRUTOS, Yibo XU, Dhileepkumar KRISHNAMURTHY, Laurence John NUMMY, Richard J. VARSOLONA, Chris Hugh SENANAYAKE, Jutta KROEBER, Diana REEVES
  • Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Patent number: 7470795
    Abstract: Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: December 30, 2008
    Assignees: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH
    Inventors: Xiao-jun Wang, Thomas Wirth, Thomas Nicola, Li Zhang, Rogelio Perez Frutos, Yibo Xu, Dhileepkumar Krishnamurthy, Laurence John Nummy, Richard J. Varsolona, Chris Hugh Senanayake, Jutta Kroeber, Diana Reeves
  • Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Publication number: 20070173517
    Abstract: Disclosed is an improved multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Application
    Filed: January 16, 2007
    Publication date: July 26, 2007
    Inventors: Thomas WIRTH, Jutta KROEBER, Thomas NICOLA, Armin RAPP, Dieter GUTHEIL, Simone ORLICH, Xiao-jun WANG, Dhileepkumar KRISHNAMURTHY
  • Process for preparing macrocyclic compounds
    Patent number: 7148347
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: December 12, 2006
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Joerg Brandenburg, Kai Donsbach, Hans-Dieter Ecker, Rogelio Perez Frutos, Fabrice Gallou, Dieter Gutheil, Nizar Haddad, Robert Hagenkoetter, Dirk Kemmer, Jutta Kroeber, Thomas Nicola, Juergen Schnaubelt, Michael Schul, Robert Donald Simpson, Xudong Wei, Eric Winter, Yibo Xu, Nathan K. Yee
  • Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Publication number: 20060025447
    Abstract: Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Application
    Filed: July 25, 2005
    Publication date: February 2, 2006
    Applicants: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH
    Inventors: Xiao-Jun Wang, Thomas Wirth, Thomas Nicola, Li Zhang, Rogelio Frutos, Yibo Xu, Dhileopkumar Krishnamurihy, Laurence Nummy, Richard Varsolona, Chris Senanayake, Jutta Kroeber
  • Process for preparing macrocyclic compounds
    Publication number: 20050049187
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: April 6, 2004
    Publication date: March 3, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Joerg Brandenburg, Kai Donsbach, Hans-Dieter Ecker, Rogelio Frutos, Fabrice Gallou, Dieter Gutheil, Nizar Haddad, Robert Hagenkoetter, Dirk Kemmer, Jutta Kroeber, Thomas Nicola, Juergen Schnaubelt, Michael Schul, Robert Simpson, Xudong Wei, Eric Winter, Yibo Xu, Nathan Yee
  • Process for preparing aryl-iminomethyl-carbamino acid esters
    Patent number: 6861547
    Abstract: The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl, cyclopentyl, cyclohexyl, phenyl, benzyl and —C(Me2)phenyl, each of which is optionally mono-, di- or trisubstituted by hydroxy; and, R2 denotes a group selected from among methyl, ethyl, propyl and benzyl.
    Type: Grant
    Filed: May 5, 2002
    Date of Patent: March 1, 2005
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Joerg Brandenburg, Rolf Schmid, Rainer Soyka, Ralf Anderskewitz, Rolf Bauer, Rainer Hamm, Jutta Kroeber
  • Process for preparing aryl-iminomethyl-carbamino acid esters
    Publication number: 20020137963
    Abstract: The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) 1
    Type: Application
    Filed: May 5, 2002
    Publication date: September 26, 2002
    Inventors: Joerg Brandenburg, Rolf Schmid, Rainer Soyka, Ralf Anderskewitz, Rolf Bauer, Rainer Hamm, Jutta Kroeber
  • Process for preparing aryl-iminomethyl-carbamino acid esters
    Patent number: 6417382
    Abstract: The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl, cyclopentyl, cyclohexyl, phenyl, benzyl and —C(Me2)phenyl, each of which is optionally mono-, di- or trisubstituted by hydroxy; and, R2 denotes a group selected from among methyl, ethyl, propyl and benzyl.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: July 9, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Joerg Brandenburg, Rolf Schmid, Rainer Soyka, Ralf Anderskewitz, Rolf Bauer, Rainer Hamm, Jutta Kroeber
  • Process for preparing aryl-iminomethyl-carbamino acid esters
    Publication number: 20010009958
    Abstract: The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) 1
    Type: Application
    Filed: January 9, 2001
    Publication date: July 26, 2001
    Inventors: Joerg Brandenburg, Rolf Schmid, Rainer Soyka, Ralf Anderskewitz, Rolf Bauer, Rainer Hamm, Jutta Kroeber