Patents by Inventor K. Anne Kronis

K. Anne Kronis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA for expression of alpha 1-antitrypsin in methylotropic yeast
    Patent number: 7270979
    Abstract: Alpha 1-antitrypsin is prepared by growing in a fermentor methylotropic yeast transformants containing in their genome at least one copy of DNA encoding alpha 1-antitrypsin, in operational linkage with DNA encoding a signal sequence, which is effective for directing secretion of proteins from the host cells, DNA constructs and recombinant yeast strains used for the expression and secretion of alpha 1-antritrypsin are also provided. The fermentation medium requires a pH of 6.5 to 7.5. The fermentation is at a pH between 5 and 6.8.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: September 18, 2007
    Assignee: Alphamed Pharmaceuticals Corp
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Treatment of osteocarcinoma with alpha-1—antitrypsin or secretory leucocyte protease inhibitor
    Patent number: 6670325
    Abstract: The present invention relates to the treatment of cancerous conditions in mammals by the administration to the site of disease compositions containing serine protease inhibitor. The cancerous conditions include osteocarcinomas, melanoma, Karopsi sarcoma and keratosis. The compositions are also useful to relieve the pain associated with the disease.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: December 30, 2003
    Assignee: Alpha Med Pharmaceuticals Corp.
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Treatment of collagen related diseases
    Patent number: 6566331
    Abstract: The present invention provides for the treatment of a patient suffering from a collagen related disease utilizing a serine protease inhibitor. The treatment includes the use of a corticosteroid that is administered separately or in combination. The serine proteases preferred are alpha 1-antitrypsin, alpha 2-macroglobulin and secretory leucocyte protease inhibitor.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: May 20, 2003
    Assignee: Alphamed Pharmaceutical Corp
    Inventors: Darren Lezdey, K. Anne Kronis, John Lezdey
  • Anti-cancer compositions
    Publication number: 20030077266
    Abstract: The present invention relates to the treatment of cancerous conditions in mammals by the administration to the site of disease compositions containing serine protease inhibitor. The cancerous conditions include osteocarcinomas, melanoma, Karopsi sarcoma and keratosis. The compositions are also useful to relieve the pain associated with the disease.
    Type: Application
    Filed: October 19, 2001
    Publication date: April 24, 2003
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Cromolyn for eye and ear infections
    Patent number: 6511960
    Abstract: The present invention provides a method and composition for treating eye and ear inflammation and eye and ear infections. The compositions contain a cromolyn compound alone or in combination with a corticosteroid. A steroidal antiphlogistic compound, a non-steroidal antiphlogistic compound and optionally hyaluronic acid may be added.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: January 28, 2003
    Assignee: Alphamed Pharmaceuticals Corp
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Oral methods of treatment
    Publication number: 20030007960
    Abstract: A method is provided for the treatment of non-pulmonary diseases and injuries by the oral administration of a stabilized protease inhibitor that transgresses the gastrointestinal tract. Crystalline, crosslinked and polyethylene glycol adducts can be used as well as coated protease inhibitors and coated stabilized protease inhibitors.
    Type: Application
    Filed: September 20, 2001
    Publication date: January 9, 2003
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • DNA for expression of alpha 1-antitrypsin in methylotrophic yeast
    Publication number: 20020164695
    Abstract: Alpha 1-antitrypsin is prepared by growing methylotropic yeast transformants containing in their genome at least one copy of DNA encoding alpha 1-antitrypsin, in operational linkage with DNA encoding a signal sequence, which is effective for directing secretion of proteins from the host cells, DNA constructs and recombinant yeast strains used for the expression and secretion of alpha 1-antritrypsin are also provided. The fermentation medium requires a pH of 6.5 to 7.5.
    Type: Application
    Filed: October 16, 2001
    Publication date: November 7, 2002
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Method for treating infectious viral diseases
    Patent number: 6468557
    Abstract: The present invention provides for the treatment of an individual suffering from infections from herpes virus or human papilloma virus by utilizing a cromolyn compound. The treatment includes the use of a corticosteroid or L-lysine that can be administered separately or in combination.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: October 22, 2002
    Assignee: AlphaMed Pharmaceutical Corp.
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Cromolyn for eye and ear infections
    Publication number: 20020091100
    Abstract: The present invention provides a method and composition for treating eye and ear inflammation and eye and ear infections. The compositions contain a cromolyn compound alone or in combination with a corticosteroid. A steroidal antiphlogistic compound, a non-steroidal antiphlogistic compound and optionally hyaluronic acid may be added.
    Type: Application
    Filed: January 5, 2001
    Publication date: July 11, 2002
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Cosmetic compositions containing cromolyn compounds for revitalizing the skin
    Patent number: 6379684
    Abstract: Cosmetic compositions and methods are provided for revitalizing the skin especially where it is placed in an environment that can cause injury to the skin. The compositions contain an effective amount of cromolyn compounds to provide a prophylactic or repairing effect.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: April 30, 2002
    Assignee: Alphamed Pharaceutical Corp.
    Inventors: John Lezdey, K. Anne Kronis, Darren Lezdey
  • Bone-stimulating, non-vasoactive parathyroid hormone variants
    Patent number: 5599792
    Abstract: Described herein are Met.sup.8 -substituted variants of parathyroid hormone that retain bone stimulating activity yet, unlike their native counterparts, have substantially no vasoactivity. Their production using recombinant DNA-based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: February 4, 1997
    Assignee: Allelix Biopharmaceuticals Inc.
    Inventors: K. Anne Kronis, Richard P. Bozzato
  • Stability-enhanced variants of parathyroid hormone
    Patent number: 5382658
    Abstract: Herein described are variants of parathyroid hormone that retain significant PTH activity and are substantially resistant to trypsin and trypsin-like enzymes. The variants are useful pharmaceutically, to treat bone disorders such as osteoporosis and in other therapeutic applications. Specific embodiments of the invention include [His.sup.25 ]PTH and [His.sup.25 His.sup.26 Leu.sup.27 ]PTH.
    Type: Grant
    Filed: April 3, 1992
    Date of Patent: January 17, 1995
    Assignees: Allelix Biopharmaceuticals Inc., Glaxo Canada Inc.
    Inventors: K. Anne Kronis, Richard P. Bozzato