Patents by Inventor K Ganesh
K Ganesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240159410Abstract: Devices, methods, and systems for detecting airflow and temperature conditions of a fire sensing device are described herein. One device includes an airflow sensor and a controller configured to receive a measurement from the airflow sensor, compare the measurement to a baseline range, and transmit a message responsive to the measurement being outside of the baseline range.Type: ApplicationFiled: November 16, 2022Publication date: May 16, 2024Inventors: Kamal Raja Ganesan, K Ganesh, Vardhaman Babu Jarale, Benjamin H. Wolf, Michael Barson
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Patent number: 11945856Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).Type: GrantFiled: January 27, 2023Date of Patent: April 2, 2024Assignee: 35PHARMA Inc.Inventors: Maureen O'Connor-McCourt, Vannakambadi K. Ganesh, Gilles Tremblay, Gauthier Schang
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Publication number: 20240105038Abstract: Methods, systems, and devices for determination and notification of a location of a building safety system event are described herein. One embodiment includes a method for notifying a user of a fire system event, comprising detecting an event in a building through an event detection device and transmitting information about at least one of the event or the event detection device to a remote server and to a first computing device. The first computing device may include a memory wherein floorplans of each floor of the building are stored.Type: ApplicationFiled: October 24, 2023Publication date: March 28, 2024Inventors: Ranjith Kumar P, K Ganesh
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Publication number: 20230340048Abstract: There are provided tetravalent TGF? receptor-ectodomain based traps having a tailored isoform-specificity profile for neutralization of TGF? ligands, and methods of use thereof in the treatment of diseases and conditions associated with TGF?, particularly TGF?1 and TGF?3. In particular, there are provided TGF? binding agents designed to tailor TGF? isoform specificity, in order to maximize therapeutic efficacy in specific disease indications while minimizing adverse effects. The TGF? binding agents comprise two polypeptides assembled via a multimerization domain, each polypeptide having two TGF?II receptor (TGF?R) ligand-binding domains linked as a doublet, wherein the linkers are selected to tailor isoform specificity.Type: ApplicationFiled: June 11, 2021Publication date: October 26, 2023Inventors: Maureen O’Connor, Gilles Tremblay, Jean-Francois Denis, Vannakambadi K. Ganesh
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Patent number: 11798387Abstract: Methods, systems, and devices for determination and notification of a location of a building safety system event are described herein. One embodiment includes a method for notifying a user of a fire system event, comprising detecting an event in a building through an event detection device and transmitting information about at least one of the event or the event detection device to a remote server and to a first computing device. The first computing device may include a memory wherein floorplans of each floor of the building are stored.Type: GrantFiled: April 12, 2022Date of Patent: October 24, 2023Assignee: Honeywell International Inc.Inventors: Ranjith Kumar P, K Ganesh
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Publication number: 20230287084Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).Type: ApplicationFiled: January 27, 2023Publication date: September 14, 2023Inventors: Maureen O'CONNOR-MCCOURT, Vannakambadi K. GANESH, Gilles TREMBLAY, Gauthier SCHANG
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Publication number: 20220335799Abstract: Methods, systems, and devices for determination and notification of a location of a building safety system event are described herein. One embodiment includes a method for notifying a user of a fire system event, comprising detecting an event in a building through an event detection device and transmitting information about at least one of the event or the event detection device to a remote server and to a first computing device. The first computing device may include a memory wherein floorplans of each floor of the building are stored.Type: ApplicationFiled: April 12, 2022Publication date: October 20, 2022Inventors: Ranjith Kumar P, K Ganesh
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Patent number: 11446371Abstract: The present invention provides methods and compositions to reduce binding of fibrinogen to the ClfA in a gram positive bacterial infections using monoclonal antibody, a polyclonal antibody, an antigen-binding antibody fragment or a composition that specifically binds to a portion of ClfA with the sequence of SEQ ID No: 15, SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18.Type: GrantFiled: November 4, 2016Date of Patent: September 20, 2022Assignee: The Texas A&M University SystemInventors: Vannakambadi K. Ganesh, Magnus Hook
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Patent number: 11041003Abstract: The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.Type: GrantFiled: October 15, 2018Date of Patent: June 22, 2021Assignee: The Texas A&M University SystemInventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Vannakambadi K. Ganesh
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Publication number: 20190150137Abstract: The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.Type: ApplicationFiled: October 15, 2018Publication date: May 16, 2019Inventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Vannakambadi K. Ganesh
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Publication number: 20180369355Abstract: The present invention provides methods and compositions to reduce binding of fibrinogen to the ClfA in a gram positive bacterial infections using monoclonal antibody, a polyclonal antibody, an antigen-binding antibody fragment or a composition that specifically binds to a portion of ClfA with the sequence of SEQ ID No: 15, SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18.Type: ApplicationFiled: November 4, 2016Publication date: December 27, 2018Inventors: Vannakambadi K. Ganesh, Magnus Hook
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Publication number: 20160194377Abstract: The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.Type: ApplicationFiled: March 22, 2016Publication date: July 7, 2016Inventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Vannakambadi K. Ganesh
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Publication number: 20150152174Abstract: The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.Type: ApplicationFiled: February 10, 2015Publication date: June 4, 2015Applicant: THE TEXAS A & M UNIVERSITY SYSTEMInventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Vannakambadi K. Ganesh
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Publication number: 20130035476Abstract: The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.Type: ApplicationFiled: September 6, 2012Publication date: February 7, 2013Applicant: THE TEXAS A & M UNIVERSITY SYSTEMInventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Vannakambadi K. Ganesh
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Patent number: 8280643Abstract: The present invention provides a method for determining the structure of a microbial surface components recognizing adhesive matrix molecule in complex with fibrinogen, by providing a ClfA complexed with a fibrinogen gamma-peptide; determining a ClfA binding region of the fibrinogen gamma-peptide; determining one or more critical amino acid residues in the ClfA binding region of a native fibrinogen gamma-peptide that is critical for a ClfA:fibrinogen gamma-peptide interaction; determining one or more amino acid residues of the ClfA that binds to the ClfA binding region of the native fibrinogen gamma-peptide; modeling the structure of the ClfA binding region; determining the structure of the ClfA in complex with the :fibrinogen gamma-peptide interaction; and identifying one or more potential agent(s) that inhibit the ClfA:fibrinogen gamma-peptide interaction without affecting binding of other proteins to the fibrinogen gamma-peptide.Type: GrantFiled: June 30, 2009Date of Patent: October 2, 2012Assignee: The Texas A & M University SystemInventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Vannakambadi K. Ganesh
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Patent number: 8025477Abstract: An aero acoustic fan assembly is provided and generally includes a fan wheel, a frame, and first and second air outlet diffusing structures. The fan wheel generally, and typically includes an axial air inlet delimited by an air inlet cone, an annular air outlet, a back plate, and front plate opposite the back plate. The frame within supports the fan wheel for rotation about a central axis thereof. The first air outlet diffusing structure is supported by a portion of the frame, adjacent the back plate of the fan wheel and includes a peripheral region. The second air outlet diffusing structure is similarly supported by a portion of the frame, adjacent the front plate of the fan wheel, and also includes a peripheral region, air exiting the annular air outlet of the fan wheel passing between the peripheral regions of the diffusing structures.Type: GrantFiled: August 24, 2005Date of Patent: September 27, 2011Assignee: Twin City Fan Companies, Ltd.Inventors: Radha K. Ganesh, Richard D. Williamson, Jonathan C. Weeks, Tatyana S. Solomakhova
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Publication number: 20110171285Abstract: The present invention describes the design and development of new fibrinogen and fibrinogen derived products with significantly reduced binding to bacteria while retaining normal physiological functions by using modified fibrinogen amino acid sequences. The present invention describes modified sequences of Fg ?-chains and ?-chains with reduced binding to S. aureus ClfA and S. epidermidis SdrG respectively. Modified Fg with the described modifications will not bind other bacterial surface proteins that bind Fg using similar mechanisms as ClfA and SdrG. These new Fg and Fg derived products will therefore have less binding to bacteria and will be advantageous compared to normal human Fg in a number of different settings.Type: ApplicationFiled: October 28, 2010Publication date: July 14, 2011Applicant: THE TEXAS A&M UNIVERSITY SYSTEMInventors: MAGNUS HOOK, VANNAKAMBADI K. GANESH, EMANUEL SMEDS
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Publication number: 20100015138Abstract: The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.Type: ApplicationFiled: June 30, 2009Publication date: January 21, 2010Inventors: Magnus Hook, Ya-Ping Ko, Emanuel Smeds, Yannakambadi K. Ganesh
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Publication number: 20080166223Abstract: An aero acoustic fan assembly is provided and generally includes a fan wheel, a frame, and first and second air outlet diffusing structures. The fan wheel generally, and typically includes an axial air inlet delimited by an air inlet cone, an annular air outlet, a back plate, and front plate opposite the back plate. The frame within supports the fan wheel for rotation about a central axis thereof. The first air outlet diffusing structure is supported by a portion of the frame, adjacent the back plate of the fan wheel and includes a peripheral region. The second air outlet diffusing structure is similarly supported by a portion of the frame, adjacent the front plate of the fan wheel, and also includes a peripheral region, air exiting the annular air outlet of the fan wheel passing between the peripheral regions of the diffusing structures.Type: ApplicationFiled: August 24, 2005Publication date: July 10, 2008Applicant: TWIN CITY FAN COMPANIES, LTD.Inventors: Radha K. Ganesh, Richard D. Williamson, Jonathan C. Weeks, Tatyana S. Solomakhova