Patents by Inventor Károly Ágoston
Károly Ágoston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132440Abstract: The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2): or a salt thereof, wherein R1 is hydrogen, a C1-50 alkyl, preferably a C1-15 alkyl, more preferably a C10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group, with a compound of formula (3): wherein the bond represents a double or a single bond, W is C, or C(OR4), Z is O, or OR5, provided that: when W is C, the bond is a double bond and Z is O, or when W is C(OR4), the bond is a single bond and Z is OR5, and wherein R2 and R3 are independently selected from a saturateType: ApplicationFiled: January 25, 2022Publication date: April 25, 2024Inventors: Katharina Kettelhoit, Gyula Dekany, Györgyi Osztrovszky, Markus Schoewe, Karoly Agoston, Ricardo Figueiredo, Jorge Santos, Fabio Pereira, Ferenc Horvath
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Patent number: 9237764Abstract: The present invention relates to a method for preparation of the trisaccharide 6?-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6?-O-sialyllactose salts in pharmaceutical or nutritional compositions.Type: GrantFiled: February 21, 2011Date of Patent: January 19, 2016Assignee: Glycom A/SInventors: Ignacio Figueroa Pérez, Ferenc Horváth, Gyula Dekany, Károly Ágoston, Ágnes Ágoston, István Bajza, Julien Boutet, Markus Hederos, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Christian Risinger
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Publication number: 20150239923Abstract: The present invention relates to the synthesis of the tetrasaccharide of formula (I) and novel intermediates used in the synthesis.Type: ApplicationFiled: March 2, 2015Publication date: August 27, 2015Inventors: István Bajza, Gyula Dekany, Károly Ágoston
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Patent number: 9012625Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.Type: GrantFiled: April 7, 2010Date of Patent: April 21, 2015Assignee: Glycom A/SInventors: Gyula Dékany, Károly Ágoston, Istvan Bajza, Julien Boutet, Marie Bøjstrup, Mette Fanefjord, Ignacio Pérez Figueroa, Markus Hederos, Ferenc Horvath, Piroska Kovács-Pénzes, Lars Kröger, Johan Olsson, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas
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Patent number: 8993740Abstract: The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.Type: GrantFiled: February 21, 2011Date of Patent: March 31, 2015Assignee: Glycom A/SInventors: István Bajza, Gyula Dekany, Károly Ágoston, Ignacio Figuero-Pérez, Julien Boutet, Markus Hederos, Ferenc Horváth, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Péter Trinka, László Kalmár, Irme Kovács, Sándor Demkó, Ágnes Ágoston, Christian Risinger
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Publication number: 20140378679Abstract: ?-Lactosamine hydrochloride, substantially free of ?-lactosamine hydrochloride; a method of preparing ?-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallisation of ?-lactosamine hydrochloride monohydrate; a method of preparing anhydrous ?-lactosamine hydrochloride; and use of ?-lactosamine hydrochloride as a food supplement or intermediate in synthesis.Type: ApplicationFiled: July 1, 2014Publication date: December 25, 2014Applicant: GLYCOM A/SInventors: Gyula DEKANY, Károly ÁGOSTON, István BAJZA, Marie BØJSTRUP, Ignacio FIGUEROA PÉREZ, Lars KRÖGER, Christoph H. RÖHRIG
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Patent number: 8889637Abstract: The present invention relates to novel polymorphs of the trisaccharide 2?-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.Type: GrantFiled: June 1, 2011Date of Patent: November 18, 2014Assignee: Glycom A/SInventors: Károly Ágoston, István Bajza, Gyula Dekany, Péter Trinka, Ágnes Ágoston, Gábor Kádár, Sándor Demkó, Ignacio Figueroa-Pérez, Markus Hederos, Ferenc Horváth, Andreas Schroven, Ioannis Vrasidas, Piroska Kovács-Pénzes, Christian Risinger, László Kalmár, Gergely Pipa, Julien Boutet, Lars Kröger, Christoph Röhrig
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Publication number: 20140228554Abstract: A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R1 or a salt thereof, wherein A and R1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.Type: ApplicationFiled: March 19, 2012Publication date: August 14, 2014Applicant: Glycom A/SInventors: Elise Champion, Gyula Dekany, Markus Hederos, Karoly Agoston
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Patent number: 8802841Abstract: A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.Type: GrantFiled: November 3, 2008Date of Patent: August 12, 2014Assignee: Glycom A/SInventors: Gyula Dekany, István Bajza, Marie Bøjstrup, Károly Ágoston, Lars Kröger, Ignacio Figueroa Pérez, Christoph H. Röhrig, Paulo Vital, Erzsébet Czinege
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Patent number: 8796434Abstract: ?-Lactosamine hydrochloride, substantially free of ?-lactosamine hydrochloride; a method of preparing ?-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallization of ?-lactosamine hydrochloride monohydrate; a method of preparing anhydrous ?-lactosamine hydrochloride; and use of ?-lactosamine hydrochloride as a food supplement or intermediate in synthesis.Type: GrantFiled: July 15, 2009Date of Patent: August 5, 2014Assignee: Glycom A/SInventors: Gyula Dekany, Károly Ágoston, István Bajza, Marie Bøjstrup, Ignacio Fegueroa Pérez, Lars Kröger, Christoph H. Röhrig
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Patent number: 8785594Abstract: The present application discloses novel glycoproteins and a related glycosylcarbamoylation methodology suitable for the preparation of glycopeptides (in particular glycoproteins and glycosylated cells), as well as the use of such glycoproteins in medicine, e.g. as pharmaceuticals and diagnostics or in diagnostic kits. A method for the preparation of a carbohydrate-peptide conjugate includes reacting a cyclic carbamate with a peptide which has at least one primary amino group.Type: GrantFiled: September 24, 2008Date of Patent: July 22, 2014Assignee: Glycom A/SInventors: Gyula Dekany, Károly Ágoston, István Bajza, Marie Bøjstrup, Lars Kröger
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Publication number: 20130172548Abstract: A method for purifying, separating and/or isolating an oligosaccharide or a salt thereof is presented. An embodiment of the invention is based upon the formation of anomeric O-benzyl/substituted O-benzyl derivatives in a selective anomeric alkylation reaction.Type: ApplicationFiled: July 15, 2011Publication date: July 4, 2013Applicant: Glycom A/S, Kgs.Inventors: Gyula Dekany, Istvan Bajza, Károly Ágoston, Ignacio Figueroa Pérez, Markus Hedros, Andreas Schroven, Ioannis Vrasidas, Julien Boutet, Lars Kröger, Christoph Röhrig, Imre Kovacs, Péter Trinka, Ágnes Ágoston, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa, Sándor Demkó, László Kalmár, Elise Champion
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Publication number: 20130165406Abstract: The present invention relates to novel polymorphs of the trisaccharide 2?-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.Type: ApplicationFiled: June 1, 2011Publication date: June 27, 2013Applicant: Glycom A/SInventors: Károly Ágoston, István Bajza, Gyula Dekany, Péter Trinka, Ágnes Ágoston, Gábor Kádár, Sándor Demkó, Ignacio Figueroa Pérez, Markus Hederos, Ferenc Horváth, Andreas Schroven, Ioannis Vrasidas, Piroska Kovács-Pénzes, Christian Risinger, László Kalmár, Gergely Pipa, Julien Boutet, Lars Kröger, Christoph Röhrig
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Publication number: 20130131334Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.Type: ApplicationFiled: April 7, 2010Publication date: May 23, 2013Applicant: Glycom A/S Danmarks Tekniske UniversitetInventors: Gyula Dékany, Károly Ágoston, Istvan Bajza, Julien Boutet, Marie Bøjstrup, Mette Fanefjord, Ignacio Pérez Figueroa, Markus Hederos, Ference Horvath, Piroska Kovács-Pénzes, Lars Kröger, Johan Olsson, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas
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Publication number: 20130035481Abstract: The present invention relates to a method for preparation of the trisaccharide 6?-0-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6?-0-sialyllactose salts in pharmaceutical or nutritional compositions.Type: ApplicationFiled: February 21, 2011Publication date: February 7, 2013Applicant: GLYCOM A/SInventors: Ignacio Pérez Figueroa, Ferenc Horváth, Gyula Dekany, Károly Ágoston, Ágnes Ágoston, István Bajza, Julien Boutet, Markus Hederos, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Christian Risinger
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Publication number: 20120309949Abstract: The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.Type: ApplicationFiled: February 21, 2011Publication date: December 6, 2012Applicant: GLYCOM A/SInventors: István Bajza, Gyula Dekany, Károly Ágoston, Ignacio Pérez Figueroa, Julien Boutet, Markus Hederos, Ferenc Horváth, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Péter Trinka, László Kalmár, Irme Kovács, Sándor Demkó, Ágnes Ágoston, Christian Risinger
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Patent number: 8207328Abstract: Lactosamine derivatives and related methods suitable for the preparation, including large-scale production, of N-acetyllactosamine, lactosamine, numerous lactosamine salts and a number of lactosamine-containing oligosaccharides are provided.Type: GrantFiled: March 13, 2007Date of Patent: June 26, 2012Assignee: Glycom ApsInventors: Gyula Dekany, Karoly Agoston, István Bajza, Marie Bøjstrup, Lars Kröger
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Publication number: 20110166339Abstract: ?-Lactosamine hydrochloride, substantially free of ?-lactosamine hydrochloride; a method of preparing ?-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallisation of ?-lactosamine hydrochloride monohydrate; a method of preparing anhydrous ?-lactosamine hydrochloride; and use of ?-lactosamine hydrochloride as a food supplement or intermediate in synthesis.Type: ApplicationFiled: July 15, 2009Publication date: July 7, 2011Applicant: GLYCOM A/SInventors: Gyula Dekany, Karoly Agoston, Istvan Bajza, Marie Bøjstrup, Ignacio Fegueroa Pérez, Lars Kröger, Christoph H. Röhrig
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Publication number: 20110060139Abstract: A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.Type: ApplicationFiled: November 3, 2008Publication date: March 10, 2011Applicant: Glycom A/SInventors: Gyula Dekany, István Bajza, Marie Bøjstrup, Karoly Agoston, Lars Kröger, Figueroa Peréz, Christoph Röhrig, Paulo Vital, Erzsébet Czinege
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Publication number: 20100261873Abstract: The present application discloses novel glycoproteins and a related glycosylcarbamoylation methodology suitable for the preparation of glycopeptides (in particular glycoproteins and glycosylated cells), as well as the use of such glycoproteins in medicine, e.g. as pharmaceuticals and diagnostics or in diagnostic kits. The method for the preparation of a carbohydrate-peptide conjugate comprises reacting a cyclic carbamate (1) (wherein R3 and R4 are hydroxyl, acetamido, or a carbohydrate moiety; and R5 is hydrogen, methyl, hydroxymethyl, acetamidomethyl, carboxyl, or X—(CH2)r—, wherein X is a carbohydrate moiety and r is an integer selected from 0, 1, 2 and 3) with a peptide comprising at least one primary amino group.Type: ApplicationFiled: September 24, 2008Publication date: October 14, 2010Inventors: Gyula Dekany, Karoly Agoston, István Bajza, Marie Bøjstrup, Lars Kröger