Patents by Inventor Kageaki Kouno

Kageaki Kouno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing daunomycin
    Patent number: 4592999
    Abstract: This invention is to provide a new microbial process for producing daunomycin by a mutant strain belonging to the genus Streptomyces.
    Type: Grant
    Filed: July 18, 1983
    Date of Patent: June 3, 1986
    Assignee: Sanraku Incorporated
    Inventors: Hamao Umezawa, Tomio Takeuchi, Kageaki Kouno, Tomoyuki Ishikura, Akihiro Yoshimoto, Yukio Takatsuki, Hiroyasu Tobe
  • Antibiotics, neoviridogriseins, and their method of production
    Patent number: 4536397
    Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: August 20, 1985
    Assignees: Sanraku-Ocean Co., Ltd., Panlabs, Inc.
    Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Antibiotics, neoviridogriseins, and their method of production
    Patent number: 4456592
    Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.
    Type: Grant
    Filed: December 23, 1981
    Date of Patent: June 26, 1984
    Assignees: Sanraku-Ocean Co., Panlabs Inc.
    Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Antibiotics and process for production thereof
    Patent number: 4451401
    Abstract: A compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or a methyl group,R.sup.1 represents a hydrogen atom or an ester residue, andR.sup.2 and R.sup.3 represent hydrogen atoms respectively, or taken together, a group of the formula ##STR2## in which each of R.sup.4 and R.sup.5 represents a hydrogen atom, a lower alkyl group or a phenyl group,and its salt; and a process for the production thereof.
    Type: Grant
    Filed: July 1, 1982
    Date of Patent: May 29, 1984
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
  • Novel .beta.-lactam compounds, process for producing thereof, and use thereof as medicines
    Patent number: 4426390
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, --OH or --OSO.sub.3 H, and R.sub.2 represents a hydrogen atom or an unsubstituted or substituted benzyl group; and a salt thereof; processes for production thereof by fermentation; and uses thereof as antimicrobial agents.
    Type: Grant
    Filed: September 29, 1981
    Date of Patent: January 17, 1984
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
  • 2-Hydroxyaclacinomycin A and 2-hydroxyaklavinone and process for preparing same
    Patent number: 4386198
    Abstract: New anthracycline compounds, 2-hydroxyaclacinomycin A having potent antitumor activity and lower toxicity, 2-hydroxyaklavinone as an useful precursor for producing anthracycline glycosides, and a process for the production thereof by microbial conversion method are disclosed.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: May 31, 1983
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Kageaki Kouno, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
  • Antibiotics and derivatives thereof having .beta.-lactamase inhibitory activity and production thereof
    Patent number: 4368203
    Abstract: A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl,and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: January 11, 1983
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Streptomyces culture
    Patent number: 4355112
    Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: October 19, 1982
    Assignees: Sanraku-Ocean Co., Ltd., Panlabs, Inc.
    Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Process for producing anthracycline glycosides
    Patent number: 4337312
    Abstract: The invention is to provide a new process for producing daunomycin and baumycins having potent antitumor activity and low toxicity by microbial conversion of anthracyclinones such as aklavinone and .epsilon.-rhodomycinone.
    Type: Grant
    Filed: August 26, 1980
    Date of Patent: June 29, 1982
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toshikazu Oki, Akihiro Yoshimoto, Kageaki Kouno, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
  • Antibiotic PS-5 and derivatives having .beta.-lactamase inhibitory activity and production thereof
    Patent number: 4318916
    Abstract: A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.
    Type: Grant
    Filed: March 2, 1978
    Date of Patent: March 9, 1982
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Process for producing cyclodextrins
    Patent number: 4317881
    Abstract: A process for producing cyclodextrins which comprises using cultured medium of the strains belonging to genus Micrococcus, filtrate thereof or enzyme preparation obtained therefrom, especially, the process in which the ratio of .alpha.-cyclodextrin to .beta.-cyclodextrin can be desirably varied by regulating the condition of the reaction mixture, is disclosed.
    Type: Grant
    Filed: March 26, 1980
    Date of Patent: March 2, 1982
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Yoshiaki Yagi, Kageaki Kouno, Taiji Inui