Abstract: The present disclosure provides a method for preparing a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors, the composition prepared by the method, and use of the composition for treating arthritis. The composition of the present disclosure achieves the effect of treating arthritis through various efficacy experiments.

Abstract: A key storage device comprising a first key unit and a second key unit is disclosed. The first key unit is configured to output a first logic value through, comprising: a first setting circuit configured to output a first setting voltage; and a first inverter comprising a first output transistor having a first threshold voltage, configured to receive the first setting voltage and generate the first logic value. The second key unit is configured to output a second logic value through a second node, comprising: a second setting circuit configured to output a second setting voltage; and a second inverter comprising a second output transistor having a second threshold voltage, configured to receive the second setting voltage and generate the second logic value. The absolute value of first threshold voltage is lower than which of the second threshold voltage. The first setting voltage is higher than the second setting voltage.

Abstract: The present disclosure provides a method for treating liver cirrhosis by using a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors. The composition of the present disclosure achieves the effect of treating liver cirrhosis through various efficacy experiments.

Abstract: The present invention relates to a method for preparing a modified stem cell, including the following steps: a cell culture step: culturing stem cells in a first culture medium of a culture dish at a predetermined cell density, and removing the first culture medium after a first culture time to obtain a first cell intermediate; an activity stimulation step: preserving the first cell intermediate in a freezing container having a cell cryopreservation solution, and performing a constant temperature stimulation treatment or a variable temperature stimulation treatment for at least more than 1 day; and a product collection step: after completing the activity stimulation step, placing the freezing container in an environment at a thawing temperature for thawing, and then removing the cell cryopreservation solution to obtain the modified stem cell. The modified stem cell can release at least one or more of IL-4, IL-5, IL-13, G-CSF, Fractalkine, and EGF.

Abstract: Disclosed in the present invention is an optimized cell transplant. The optimized cell transplant is formed by performing gene induction and modification on a mesenchymal stem cell in the form of a small molecule and protein composition. The expression levels of CD200 gene, Galectin-9 gene and VISTA gene can be increased synchronously after cell culture. Vector virus infection and plasmid transfection are not required in the cell preparation process, so that high biological safety and great clinical application value of cells are achieved.

Abstract: An entropy source circuit, comprising: a first adjustable ring oscillator for operating under a first setting or a second setting according to a first control signal, for respectively generating a first oscillation clock signal and a second oscillation clock signal which have different frequencies under the first setting and the second setting; a first sampling circuit, for sampling the first oscillating clock signal according to the sampling frequency to generate first sampling values, or sampling the second oscillating clock signal according to the sampling frequency to generate second sampling values; a first detection circuit detecting a first distribution of the first sampling values; and a control circuit generating the first control signal to switch the first setting to the second setting when the first distribution does not meet a predetermined distribution. The entropy source circuit outputs entropy values according to the first sample value or the second sample value.

Abstract: A method for generating random numbers for gaming based on a blockchain network is provided, which includes generating and broadcasting a random number request packet to the blockchain network by a game server of the blockchain network in response to occurrence of a random event in gaming, generating a plurality of random numbers by a plurality of random number supplier nodes of the blockchain network in response to receiving the random number request packet, determining if the respective generated random number conforms to a selection criterion by the plurality of random number supplier nodes, adding an added block corresponding to a first valid random number to the blockchain network by one of the random number supplier nodes and obtaining a target random number corresponding to the added block by the game server.

Abstract: A method and a control circuit for managing information of an electronic device are provided, where the electronic device includes the control chip. The method includes: utilizing a static entropy source of the control circuit to provide static entropy data; utilizing a cryptographic circuit of the control circuit to generate a public key and a private key according to the static entropy data, where the public key is to be registered into a blockchain by an identifier (ID) management device; and utilizing a signature generating circuit to generate a digital signature at least according to the private key, where the information of the electronic device is to be uploaded to the blockchain in conjunction with the digital signature.

Abstract: An entropy source circuit is provided. The entropy source circuit includes a digital circuit, a determination circuit and a time-to-digital converter (TDC), wherein the determination circuit is coupled to the digital circuit, and the TDC is coupled to the determination circuit. The digital circuit is configured to generate result data at a second time point according to input data received at a first time point, and the determination circuit is configured to perform determination on reference data with dynamic output generated by the digital circuit, to generate a determination result, wherein the reference data is equal to the result data. In addition, the TDC is configured to perform a time-to-digital conversion on a delay of the digital circuit for generating the result data according to the input data with aid of the determination signal, in order to generate entropy data corresponding to the delay.

Abstract: A built-in self-test (BIST) circuit and a BIST method for Physical Unclonable Function (PUF) quality check are provided. The BIST circuit may include a PUF array, a readout circuit coupled to the PUF array, and a first comparing circuit coupled to the readout circuit. The PUF array may include a plurality of PUF units, wherein each of the PUF units includes a first cell and a second cell. The readout circuit may be configured to output an output bit from the first cell and output a parity bit from the second cell. The first comparing circuit may be configured to compare an output string with a parity string to generate a parity check result, wherein the output string includes output bits respectively read from selected PUF units of the PUF units, and the parity string includes parity bits read from the selected PUF units.

Abstract: A key storage device comprising a first key unit and a second key unit is disclosed. The first key unit is configured to output a first logic value through, comprising: a first setting circuit configured to output a first setting voltage; and a first inverter comprising a first output transistor having a first threshold voltage, configured to receive the first setting voltage and generate the first logic value. The second key unit is configured to output a second logic value through a second node, comprising: a second setting circuit configured to output a second setting voltage; and a second inverter comprising a second output transistor having a second threshold voltage, configured to receive the second setting voltage and generate the second logic value. The absolute value of first threshold voltage is lower than which of the second threshold voltage. The first setting voltage is higher than the second setting voltage.

Abstract: A Physical Unclonable Function (PUF) based true random number generator (TRNG), a method for generating true random numbers, and an associated electronic device are provided. The PUF based TRNG may include a first obfuscation circuit, a cryptography circuit coupled to the first obfuscation circuit, and a second obfuscation circuit coupled to the cryptography circuit. The first obfuscation circuit obtains a first PUF value from a PUF pool of the electronic device, and performs a first obfuscation function on a preliminary seed based on the first PUF value to generate a final seed. The cryptography circuit utilizes the final seed as a key of a cryptography function to generate preliminary random numbers. The second obfuscation circuit obtains a second PUF value from the PUF pool, and performs a second obfuscation function on the preliminary random numbers based on the second PUF value to generate final random numbers.

Abstract: A method and a control circuit for managing information of an electronic device are provided, where the electronic device includes the control chip. The method includes: utilizing a static entropy source of the control circuit to provide static entropy data; utilizing a cryptographic circuit of the control circuit to generate a public key and a private key according to the static entropy data, where the public key is to be registered into a blockchain by an identifier (ID) management device; and utilizing a signature generating circuit to generate a digital signature at least according to the private key, where the information of the electronic device is to be uploaded to the blockchain in conjunction with the digital signature.

Abstract: A random number generator and a random number generating method are provided. The random number generator includes a first stage generator and a second stage generator. The first stage generator outputs a first random number and a second random number at a first time point and a second time point, respectively. The second stage generator generates a final output at least according to the first random number. More particularly, the second stage generator includes a reseed circuit for generating a reseed signal, to control whether to generate the final output according to the second random number. In addition, when the second stage generator generates the final output at a current data cycle without using the second random number, the first stage generator holds the second random number for generating the final output at a next data cycle.

Abstract: A built-in self-test (BIST) circuit and a BIST method for Physical Unclonable Function (PUF) quality check are provided. The BIST circuit may include a PUF array, a readout circuit coupled to the PUF array, and a first comparing circuit coupled to the readout circuit. The PUF array may include a plurality of PUF units, wherein each of the PUF units includes a first cell and a second cell. The readout circuit may be configured to output an output bit from the first cell and output a parity bit from the second cell. The first comparing circuit may be configured to compare an output string with a parity string to generate a parity check result, wherein the output string includes output bits respectively read from selected PUF units of the PUF units, and the parity string includes parity bits read from the selected PUF units.

Abstract: A Physical Unclonable Function (PUF) based true random number generator (TRNG), a method for generating true random numbers, and an associated electronic device are provided. The PUF based TRNG may include a first obfuscation circuit, a cryptography circuit coupled to the first obfuscation circuit, and a second obfuscation circuit coupled to the cryptography circuit. The first obfuscation circuit obtains a first PUF value from a PUF pool of the electronic device, and performs a first obfuscation function on a preliminary seed based on the first PUF value to generate a final seed. The cryptography circuit utilizes the final seed as a key of a cryptography function to generate preliminary random numbers. The second obfuscation circuit obtains a second PUF value from the PUF pool, and performs a second obfuscation function on the preliminary random numbers based on the second PUF value to generate final random numbers.