Patents by Inventor Kak-Shan Shia

Kak-Shan Shia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANOPARTICLES AND LIPOSOMES
    Publication number: 20230320987
    Abstract: Disclosed is a pharmaceutical nanoparticle containing a core and a shell coating the core. The core contains (3-{4-[2-({4-[3-(3-cyclohexylamino-propylamino)-propyl]-oxazol-2-ylmethyl}-amino)-6-methyl-pyrimidin-4-ylamino]-piperidin-1-yl}-3-oxo-propylamino)-acetic acid or a salt thereof, 1,2-dioleoyl-sn-glycero-3-phosphate, and an anionic polymer. The shell contains a lipid. Also disclosed is a method for preparing such as pharmaceutical nanoparticle. Further provided are a liposome containing a lipid bilayer enclosing an aqueous core and its preparation method.
    Type: Application
    Filed: April 5, 2023
    Publication date: October 12, 2023
    Inventors: Yunching Chen, Kak-Shan Shia, Chiung-Tong Chen, Chien-Huang Wu, Ya-Ping Chen
  • PYRIMIDINE COMPOUNDS AND USE THEREOF
    Publication number: 20230085362
    Abstract: Pyrimidine compounds of formula (I) shown herein. Also disclosed are pharmaceutical compositions containing one of the pyrimidine compounds and methods of using the pyrimidine compounds to treat or prevent chemotherapy-induced peripheral neuropathy.
    Type: Application
    Filed: July 29, 2022
    Publication date: March 16, 2023
    Inventors: Jang-Yang Chang, Meng-Ru Shen, Kak-Shan Shia, Chien-Huang Wu
  • Heterocyclic compounds and use thereof
    Patent number: 10882854
    Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further disclosed are methods of using one of the heterocyclic compounds for mobilizing hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation, and for treating tissue injury, cancer, inflammatory disease, and autoimmune disease.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: January 5, 2021
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chien-Huang Wu, Ming-Chen Chou, Jen-Shin Song, Yun Wang, Chuan Shih
  • HETEROCYCLIC COMPOUNDS AND USE THEREOF
    Publication number: 20180208588
    Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further disclosed are methods of using one of the heterocyclic compounds for mobilizing hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation, and for treating tissue injury, cancer, inflammatory disease, and autoimmune disease.
    Type: Application
    Filed: January 8, 2018
    Publication date: July 26, 2018
    Inventors: Kak-Shan Shia, Chien-Huang Wu, Ming-Chen Chou, Jen-Shin Song, Yun Wang, Chuan Shih
  • Heterocyclic compounds and use thereof
    Patent number: 9926298
    Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: March 27, 2018
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Jiing-Jyh Jan, Lun Kelvin Tsou, Chiung-Tong Chen, Yu-Sheng Chao
  • HETEROCYCLIC COMPOUNDS AND USE THEREOF
    Publication number: 20180009786
    Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 11, 2018
    Inventors: Kak-Shan Shia, Jiing-Jyh Jan, Lun Kelvin Tsou, Chiung-Tong Chen, Yu-Sheng Chao
  • Heterocyclic compounds and use thereof
    Patent number: 9862703
    Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: January 9, 2018
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Jiing-Jyh Jan, Lun Kelvin Tsou, Chiung-Tong Chen, Yu-Sheng Chao
  • Dipicolylamine derivatives and their pharmaceutical uses
    Patent number: 9388193
    Abstract: Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, with these compounds.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: July 12, 2016
    Assignees: National Health Research Institutes, Molecular Targeting Technologies, Inc.
    Inventors: Chiung-Tong Chen, Kak-Shan Shia, Chien-Huang Wu, Lun-Kelvin Tsou, Yu-Sheng Chao
  • HETEROCYCLIC COMPOUNDS AND USE THEREOF
    Publication number: 20160083369
    Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.
    Type: Application
    Filed: September 21, 2015
    Publication date: March 24, 2016
    Inventors: Kak-Shan Shia, Jiing-Jyh Jan, Lun Kelvin Tsou, Chiung-Tong Chen, Yu-Sheng Chao
  • DIPICOLYLAMINE DERIVATIVES AND THEIR PHARMACEUTICAL USES
    Publication number: 20150336976
    Abstract: Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, with these compounds.
    Type: Application
    Filed: May 14, 2015
    Publication date: November 26, 2015
    Inventors: Chiung-Tong Cheng, Kak-Shan Shia, Chien-Huang Wu, Lun-Kelvin Tsou, Yu-Sheng Chao
  • Pyrazole compounds
    Patent number: 8962845
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, and X are defined herein. Also disclosed are pharmaceutical compositions and methods related to use of these compounds.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: February 24, 2015
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chun-Ping Chang, Yu-Sheng Chao
  • PYRAZOLE COMPOUNDS
    Publication number: 20130085126
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, and X are defined herein. Also disclosed are pharmaceutical compositions and methods related to use of these compounds.
    Type: Application
    Filed: September 25, 2012
    Publication date: April 4, 2013
    Applicant: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chun-Ping Chang, Yu-Sheng Chao
  • Imidazol-4-one and imidazole-4-thione compounds
    Patent number: 8354442
    Abstract: Imidazol-4-one or imidazole-4-thione compounds of formula (I): wherein X, R1, R2, R3, R4, R5, and R6 are defined herein. Also disclosed is a method for treating a cannabinoid receptor-mediated disorder with these compounds.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: January 15, 2013
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chien-Huang Wu, Teng-Kuang Yeh, Yu-Sheng Chao
  • Thiophene compounds
    Patent number: 7834046
    Abstract: This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: November 16, 2010
    Assignee: National Health Research Institutes
    Inventors: Kak-shan Shia, Chia-Liang Tai, Jyh-hsiung Liao, Ming-shiu Hung, Yu-Sheng Chao
  • Selenophene compounds
    Patent number: 7803799
    Abstract: This invention relates to selenophene compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: September 28, 2010
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Jing-Po Tsao, Chia-Liang Tai, Wan-Ping Hsieh, Ming-Shiu Hung, Jen-Shin Song, Yu-Sheng Chao
  • Imidazol-4-one and Imidazole-4-thione Compounds
    Publication number: 20100113546
    Abstract: Imidazol-4-one or imidazole-4-thione compounds of formula (I): wherein X, R1, R2, R3, R4, R5, and R6 are defined herein. Also disclosed is a method for treating a cannabinoid receptor-mediated disorder with these compounds.
    Type: Application
    Filed: October 30, 2009
    Publication date: May 6, 2010
    Applicant: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chien-Huang Wu, Teng-Kuang Yeh, Yu-Sheng Chao
  • Oxadiazole compounds
    Patent number: 7705024
    Abstract: A compound of formula (I): in which A, R1, R2, and R3 are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating a cannabinoid receptor-mediated disorder using such a compound.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: April 27, 2010
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Cheng-ming Chu, Jing-po Tsao, Yu-Sheng Chao, Jen-shin Song
  • Synthesis of polyamine compounds
    Patent number: 7501526
    Abstract: This invention relates to methods of preparing the compounds of formula (V): Each variable in this formula is defined in the specification.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: March 10, 2009
    Assignee: Taigen Biotechnology
    Inventors: Chien-Huang Wu, Jia-Liang Zhu, Chen-Tso Tseng, Chi-Feng Yen, Kak-Shan Shia, Yibin Xiang, Gholam Hossein Hakimelahi, Ming-Chen Chou
  • PYRAZOLE COMPOUNDS
    Publication number: 20090042864
    Abstract: This invention relates to pyrazole compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Application
    Filed: October 2, 2007
    Publication date: February 12, 2009
    Applicant: National Health Research Institutes
    Inventors: Kak-shan Shia, Chia-Liang Tai, Jing-po Tsao, Wan-ping Hsieh, Shi-Liang Tseng, Yu-Sheng Chao, Ming-shiu Hung
  • Thiophene Compounds
    Publication number: 20090029969
    Abstract: This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Application
    Filed: October 2, 2007
    Publication date: January 29, 2009
    Applicant: National Health Research Institutes
    Inventors: Kak-shan Shia, Chia-Liang Tai, Jyh-hsiung Liao, Ming-shiu Hung, Yu-Sheng Chao