Abstract: In some aspects, a device comprises a substrate and at least one CMUT located on or in the substrate that provides ultrasound radiation to a brain of a patient. In some aspects, a method of guiding ultrasound radiation in the brain of a patient comprises receiving as a first input patient scan data, receiving as a second input information regarding configuration and/or properties of ultrasound transmitters adapted to transmit to the brain the ultrasound radiation, processing at least one of the first and second inputs and feeding the processed at least one of the first and second inputs into a physical acoustics model, and based on an output of the physical acoustics model and acquired data from the brain of the patient, generating an instruction to transmit to the brain of the patient the ultrasound radiation.

Abstract: In some aspects, a device wearable by a person includes a transducer configured to apply to the brain of the person acoustic signals.

Abstract: In some aspects, a device includes a sensor configured to detect a signal from the brain of the person and a plurality of transducers, each configured to apply to the brain an acoustic signal. One of the plurality of transducers is selected using a statistical model trained on data from prior signals detected from the brain.

Abstract: In some aspects, a device wearable by a person includes a sensor configured to detect a signal from the brain of the person and a transducer configured to apply to the brain an ultrasound signal. The ultrasound signal has a low power density and is substantially non-destructive with respect to tissue when applied to the brain.

Abstract: In some aspects, the described systems and methods provide for a method comprising transmitting to a brain of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the brain, with the at least one transducer, data acquired from the brain including information related to standing waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises determining, from the acquired data, intracranial pressure of the person.

Abstract: In some aspects, the described systems and methods provide for a method comprising transmitting, with at least one transducer, acoustic signals to a brain of a patient, wherein the at least one transducer is configured to induce excitation of a plurality of acoustic modes. The method further comprises receiving, with the at least one transducer, data acquired from the brain including information related to standing waves, frequency response, impulse/transient response, and/or distribution of acoustic modes. The method further comprises determining, from the acquired data, a location of a seizure site within the brain of the person.

Abstract: In some aspects, the described systems and methods provide for a method comprising transmitting to a brain and/or skull of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the brain and/or skull, with the at least one transducer, data acquired from the brain and/or skull including information related to standing waves, guided waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises determining, from the acquired data, presence of a tumor within the brain of the person.

Abstract: In some aspects, the described systems and methods provide for a method comprising transmitting to a brain of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the brain, with the at least one transducer, data acquired from the brain including information related to standing waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises detecting, from the acquired data, a seizure of the person.

Abstract: In some aspects, the described systems and methods provide for a method comprising transmitting, with at least one transducer, acoustic signals to a brain of a patient, wherein the at least one transducer is configured to induce excitation of a plurality of acoustic modes. The method further comprises receiving, with the at least one transducer, data acquired from the brain including information related to standing waves, frequency response, impulse/transient response, and/or distribution of acoustic modes. The method further comprises determining, from the acquired data, a distribution of intracranial pressure within the brain of the person.

Abstract: In some aspects, the described systems and methods provide for a method comprising transmitting to a skull of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the skull, with the at least one transducer, data acquired from the skull including information related to guided waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises determining, from the acquired data, intracranial pressure of the person.

Abstract: Improved acoustic neurostimulation is provided by having two or more acoustic transducers generate an acoustic interference pattern in a region of a patient being treated. The apparatus has at least two operating modes it can switch between. A first operating mode has the transducers driven at the same frequency. A second operating mode has the transducers driven at different frequencies. Full control of the acoustic transducers allows the acoustic interference pattern to be varied electronically at will.

Abstract: In some aspects, a closed-loop system for monitoring and/or treating brain function of a person includes a CMUT device that transmits ultrasound radiation to the brain of the person and receives and detects an ultrasound signal generated in the brain, and a processor that assesses the received ultrasound signal to determine brain function and controls further transmission of ultrasound radiation from the CMUT device based on the determined brain function.

Abstract: In some aspects, a sensor includes an optical transmitter that transmits to a brain of a person infrared radiation, and an acoustic receiver that detects an ultrasound signal generated in the brain in response to the infrared radiation. A processor determines oxygen saturation of the brain based on the detected ultrasound signal. The sensor may be included in a cap worn by the person, implanted under the skin of the person, or inserted through the nasal canal of the person.

Abstract: Clamp-on ultrasonic flow metering is provided by collectively exciting and receiving circumferential modes of the pipe. The pipe wall supports an infinite number of circumferential acoustic resonances. Each of these modes, in contact with a fluid, can mode-convert into the flow at a different rate. The mode-converted waves in the flow mode-convert back into the circumferential waves in the pipe once they travel across the flow. Furthermore, the moving fluid alters the rate of mode-conversion as a function of the flow velocity. At low frequencies, the wavelength is larger, thus the penetration depth in the flow is larger. As the frequency increases, the penetration depth becomes smaller. The variable penetration depth provides a methodology to sample the flow velocity profile.

Abstract: In some aspects, a device wearable by a person includes a transducer configured to apply to the brain of the person acoustic signals.

Abstract: In some aspects, a device includes a sensor configured to detect a signal from the brain of the person and a plurality of transducers, each configured to apply to the brain an acoustic signal. One of the plurality of transducers is selected using a statistical model trained on data from prior signals detected from the brain.

Abstract: In some aspects, a device wearable by or attached to or implanted within a person includes a sensor configured to detect an electroencephalogram (EEG) signal from the brain of the person and a transducer configured to apply to the brain a low power, substantially non-destructive ultrasound signal.

Abstract: In some aspects, a device wearable by a person includes a sensor configured to detect a signal from the brain of the person and a transducer configured to apply to the brain an ultrasound signal. The ultrasound signal has a low power density and is substantially non-destructive with respect to tissue when applied to the brain.

Abstract: In some aspects, a device includes a sensor configured to detect a signal from the brain of the person and a plurality of transducers, each configured to apply to the brain an acoustic signal. One of the plurality of transducers is selected using a statistical model trained on signal data annotated with one or more values relating to identifying a health condition.

Abstract: In some aspects, a device wearable by or attached to or implanted within a person includes a sensor configured to detect a signal from the brain of the person and a transducer configured to apply to the brain an acoustic signal.