Patents by Inventor Kanad Das
Kanad Das has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240116983Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1—X2—X3—X4—X5—X6—X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2—X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: October 4, 2022Publication date: April 11, 2024Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Publication number: 20200399309Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Publication number: 20190194252Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: March 11, 2019Publication date: June 27, 2019Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Patent number: 10280198Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: GrantFiled: June 21, 2017Date of Patent: May 7, 2019Assignee: KAI PHARMACEUTICALS, INC.Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Publication number: 20180022777Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: June 21, 2017Publication date: January 25, 2018Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Patent number: 9701712Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1—X2—X3—X4—X5—X6—X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: GrantFiled: February 8, 2016Date of Patent: July 11, 2017Assignee: KAI Pharmaceuticals, Inc.Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Publication number: 20170114095Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: January 9, 2017Publication date: April 27, 2017Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Patent number: 9567370Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: GrantFiled: March 4, 2015Date of Patent: February 14, 2017Assignee: KAI PHARMACEUTICALS, INC.Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Publication number: 20160159860Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: February 8, 2016Publication date: June 9, 2016Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Patent number: 9278995Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: GrantFiled: February 18, 2013Date of Patent: March 8, 2016Assignee: KAI PHARMACEUTICALS, INC.Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Publication number: 20150175664Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: March 4, 2015Publication date: June 25, 2015Inventors: FELIX KARIM, AMOS BARUCH, DEREK MACLEAN, KANAD DAS, QUN YIN
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Patent number: 8999932Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: GrantFiled: July 29, 2010Date of Patent: April 7, 2015Assignee: KAI Pharmaceuticals, Inc.Inventors: Felix Karim, Amos Baruch, Derek Maclean, Kanad Das, Qun Yin
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Patent number: 8377880Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1—X2—X3—X4—X5—X6—X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2—X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: GrantFiled: February 2, 2012Date of Patent: February 19, 2013Assignee: KAI Pharmaceuticals, Inc.Inventors: Felix Karim, Amos Baruch, Derek MacLean, Kanad Das, Qun Yin
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Publication number: 20120178688Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: February 2, 2012Publication date: July 12, 2012Applicant: KAI PHARMACEUTICALS, INC.Inventors: FELIX KARIM, AMOS BARUCH, DEREK MACLEAN, KANAD DAS, QUN YIN
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Patent number: 7720049Abstract: A service broker of telecommunications networks is described herein. According to one embodiment, in response to a telephony call event from a subscriber to be serviced by a plurality of services, for each of the plurality of services, a service description associated with the respective service is examined to identify which of the plurality of service is capable of handling the telephony call event, where the service description semantically describes the respective service. Thereafter, the telephony call event is distributed to one or more of the identified services that are capable of handling the telephony call event, where the telephony call event is processed by the one or more services. Other methods and apparatuses are also described.Type: GrantFiled: March 3, 2005Date of Patent: May 18, 2010Assignee: Veraz Networks, Inc.Inventors: Vladimir Mikhailov, Romolo Raffo, Kanad Das, Seshagiri Rao, Shawn Pouliotte
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Publication number: 20040234954Abstract: A thin film made of a stiff polymer and having indentations on its surface, and methods of making and using the thin film are disclosed. The surface includes a plurality of indentations, the shape of each indentation corresponding to an outer surface of an imprint moiety, such as an animal, bacterial, or plant cell. The thin film can be mounted on a detector, which can be used to selectively bind to and detect the imprint moiety in a sample, e.g., a biological or environmental sample, at a minimum concentration of as low as 500 to 1000 imprint moieties per milliliter of sample.Type: ApplicationFiled: March 3, 2004Publication date: November 25, 2004Inventors: Klaus Nusslein, Jacques Penelle, Kanad Das
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Patent number: 6486344Abstract: The present invention is based on a series of acrylic cross-linking agents containing two or more dehydroalanine moieties (H2C═C(NHCOR′)COOR) per monomer. Monomers of the general structure H2C═C(NHCOCH3)COO(CH2)iOO(CH3CONH) C═CH2 with i=4, 5, and 8 can be polymerized or copolymerized under UV-curing conditions or by simple heating above melting point, leading to cross-linked polymeric materials. When polymerized on metallic surfaces, exceptional adhesion is obtained with no need for additional adhesion enhancers.Type: GrantFiled: July 26, 2001Date of Patent: November 26, 2002Inventors: Jaques Penelle, Tao Xie, Kanad Das