Abstract: An adhesive skin patch sheet comprises a support, a pressure-sensitive adhesive layer and a release sheet laminated in that order, the release sheet is divided by a cut line into a small first release sheet and a large second release sheet, the cut line is formed so as to be convex only from the second release sheet toward the first release sheet.

Abstract: A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum release member constituted from a sheet-like first supporting substrate and a pressure-sensitive adhesive layer laminated on the first supporting member; a medicinal-components administration member constituted from a sheet-like second supporting substrate, a medicinal-components retention layer laminated on the second supporting substrate, and a protect layer laminated on the medicinal-components retention layer; and a sheet-like handling member interposed between the stratum-corneum release member and the medicinal-components administration member. An edge portion of the handling member is coupled to or integrated with both the first supporting substrate and the protect layer.

Abstract: The transdermal administration device of the present invention includes: a device body including a needle form body, which includes a plurality of microneedles formed on a surface thereof and is provided with a fluid passage hole through the front surface to a back surface thereof, and a medical fluid filling section for providing a medical fluid to the back surface of the needle form body; a stratum corneum peeling system; and a connection section for connecting the device body and the stratum corneum peeling system, where the stratum corneum peeling system is connected to the device body by the connection section such that the microneedles of the needle form body of the device body are positioned in an area of a skin surface in which a stratum corneum is peeled by the stratum corneum peeling system.

Abstract: A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum release member constituted from a sheet-like first supporting substrate and a pressure-sensitive adhesive layer laminated on the first supporting member; a medicinal-components administration member constituted from a sheet-like second supporting substrate, a medicinal-components retention layer laminated on the second supporting substrate, and a protect layer laminated on the medicinal-components retention layer; and a sheet-like handling member interposed between the stratum-corneum release member and the medicinal-components administration member. An edge portion of the handling member is coupled to or integrated with both the first supporting substrate and the protect layer.

Abstract: A adhesive skin patch sheet comprises a support, a pressure-sensitive adhesive layer and a release sheet laminated in that order, the release sheet is divided by a cut line into a small first release sheet and a large second release sheet, the cut line is formed so as to be convex only from the second release sheet toward the first release sheet.

Abstract: Disclosed is a keratin layer improving laminated sheet comprising a fixing adhesive sheet having an adhesive layer on an adhesive sheet substrate and a moisture retaining pad having a moisturizing agent-containing polymer layer on a pad substrate, said moisture retaining pad being fixed to the fixing adhesive sheet in such a manner that the pad substrate of the moisture retaining pad is in contact with the adhesive layer of the fixing adhesive sheet, wherein in 100% by weight of the moisturizing agent-containing polymer layer, glycerol as a moisturizing agent is contained in an amount of 25 to 55% by weight and moisturizing agents including glycerol are contained in a total amount of 30 to 60% by weight.

Abstract: The invention relates to a percutaneous absorption preparation which comprises a supporting body, a medicine storage layer, a permeation controlling film, a layer of an adhesive and a release liner and which is featured in that the above-mentioned permeation controlling film is plasticized by moisture volatilized from the skin at the time of application of the preparation.